{"id":1296,"date":"2020-06-04T02:00:06","date_gmt":"2020-06-04T02:00:06","guid":{"rendered":"\/\/smallcapscn.x5view.co\/?p=1296"},"modified":"2023-08-29T17:45:32","modified_gmt":"2023-08-29T17:45:32","slug":"dimerix-lead-drug-candidate-key-clinical-study-covid-19-respiratory-patients","status":"publish","type":"post","link":"https:\/\/smallcapscn.x5view.co\/?p=1296","title":{"rendered":"Dimerix\u7684\u4e3b\u5019\u9009\u836f\u7269\u5c06\u88ab\u7eb3\u5165\u51a0\u72b6\u75c5\u6bd2\u547c\u5438\u7cfb\u7edf\u60a3\u8005\u7684\u5173\u952e\u4e34\u5e8a\u7814\u7a76"},"content":{"rendered":"

\u4e34\u5e8a\u751f\u7269\u5236\u836f\u516c\u53f8Dimerix Limited (ASX: DXB)<\/a>\u5f00\u53d1\u7684\u4e00\u79cd\u5019\u9009\u836f\u7269\u5df2\u88ab\u7eb3\u5165\u4e00\u9879\u5168\u7403\u7814\u7a76\uff0c\u8be5\u7814\u7a76\u65e8\u5728\u6cbb\u7597\u7531\u51a0\u72b6\u75c5\u6bd2\u5bfc\u81f4\u7684\u6025\u6027\u547c\u5438\u7a98\u8feb\u7efc\u5408\u5f81(ARDS)\u60a3\u8005\u3002<\/p>\n

\u793e\u533a\u83b7\u5f97\u6027\u80ba\u708e\u968f\u673a\u3001\u5d4c\u5165\u5f0f\u3001\u591a\u56e0\u7d20\u81ea\u9002\u5e94\u5e73\u53f0\u8bd5\u9a8c(REMAP-CAP)\u9879\u76ee\u5c06\u4fa7\u91cd\u4e8e\u5bf9\u5df2\u8bc1\u5b9e\u6216\u7591\u4f3c\u51a0\u72b6\u75c5\u6bd2\u7684\u4f4f\u9662\u60a3\u8005\u7684\u591a\u79cd\u5e72\u9884\u63aa\u65bd\uff0c\u8fd9\u4e9b\u60a3\u8005\u5c06\u767b\u8bb0\u5728\u91cd\u75c7\u76d1\u62a4\u5ba4\u548c\u975e\u91cd\u75c7\u76d1\u62a4\u5ba4\u3002<\/p>\n

\u9009\u62e9Dimerix\u7684\u7814\u53d1\u836f\u7269DMX-200\uff0c\u662f\u56e0\u4e3a\u5b83\u6709\u53ef\u80fd\u901a\u8fc7\u51cf\u5c11\u80ba\u90e8\u708e\u75c7\u53cd\u5e94\u3001\u51cf\u5c11\u708e\u75c7\u548c\u968f\u540e\u7684\u7ea4\u7ef4\u5316\u800c\u4f7fARDS\u60a3\u8005\u53d7\u76ca\u3002<\/p>\n

\u6839\u636e\u76d1\u7ba1\u548c\u4f26\u7406\u65b9\u9762\u7684\u6279\u51c6\uff0cDimerix\u5c06\u4ece\u5176\u73b0\u6709\u7684\u836f\u54c1\u7ea7\u751f\u4ea7\u4f9b\u5e94\u4e2d\u63d0\u4f9b\u6570\u91cf\u7684\u836f\u7269\u3002<\/p>\n

\u9664\u4e86\u5df2\u5728\u6240\u6709\u5173\u952e\u5730\u533a\u6388\u4e88\u7684CCR2\u6291\u5236\u5242(\u5305\u62ecDMX-200)\u6cbb\u7597ARDS\u7684\u4e13\u5229\u5916\uff0c\u8be5\u516c\u53f8\u8fd8\u63d0\u4ea4\u4e86\u4e34\u65f6\u4e13\u5229\u7533\u8bf7\u3002<\/p>\n

\u4e34\u5e8a\u5f71\u54cd<\/h2>\n

\u9996\u5e2d\u6267\u884c\u5b98Nina Webster\u535a\u58eb\u8bf4\uff0cDimerix\u975e\u5e38\u613f\u610f\u652f\u6301\u5168\u7403\u51a0\u72b6\u75c5\u6bd2\u6cbb\u7597\u5de5\u4f5c\u3002<\/p>\n

\u5979\u8bf4:\u201c\u8fd9\u9879\u8bd5\u9a8c\u53ef\u80fd\u5bf9\u4e00\u79cd\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u9ad8\u3001\u6709\u6548\u7597\u6cd5\u5f88\u5c11\u7684\u75be\u75c5\u4ea7\u751f\u5de8\u5927\u7684\u4e34\u5e8a\u5f71\u54cd\u3002\u201d<\/p>\n

\u201c\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u80fd\u591f\u652f\u6301\u5bf9\u6b7b\u4e8eARDS\u60a3\u8005\u7684\u591a\u79cd\u6cbb\u7597\u65b9\u6cd5\u7684\u7814\u7a76\u3002\u201d<\/p>\n

\u6d41\u884c\u75c5\u7814\u7a76
\nREMAP-CAP\u88ab\u6307\u5b9a\u4e3a\u4e00\u9879\u5927\u6d41\u884c\u7279\u522b\u7814\u7a76\uff0c\u7531\u4e00\u4e2a\u7531\u4e13\u5bb6\u3001\u673a\u6784\u548c\u7814\u7a76\u5c0f\u7ec4\u7ec4\u6210\u7684\u7f51\u7edc\u9886\u5bfc\uff0c\u5e76\u5f97\u5230\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u7684\u8ba4\u53ef\u3002<\/p>\n

\u8fd9\u4e00\u6307\u5b9a\u786e\u4fdd\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u7684\u77e5\u8bc6\u8f6c\u5316\u53ef\u4ee5\u76f4\u63a5\u4e0e\u51b3\u7b56\u8005\u548c\u516c\u5171\u536b\u751f\u5b98\u5458\u8fdb\u884c\uff0c\u4ee5\u4fbf\u6839\u636e\u9700\u8981\u5728\u5168\u7403\u8fc5\u901f\u5b9e\u65bd\u3002<\/p>\n

\u8be5\u7814\u7a76\u5df2\u88ab\u82f1\u56fd\u9996\u5e2d\u533b\u7597\u5b98\u6307\u5b9a\u4e3a\u51a0\u72b6\u75c5\u6bd2\u7684\u5173\u952e\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n

\u5c3d\u7ba1\u9002\u5e94\u6027\u7814\u7a76\u5f00\u59cb\u65f6\u7684\u5177\u4f53\u6570\u5b57\u5c1a\u672a\u660e\u786e\uff0c\u4f46\u8ba1\u5212\u5c06\u4e9a\u592a\u3001\u6b27\u6d32\u548c\u5317\u7f8e\u7684200\u4e2a\u5df2\u7ecf\u542f\u52a8\u7684\u7814\u7a76\u5730\u70b9\u76847000\u591a\u540d\u60a3\u8005\u7eb3\u5165\u7814\u7a76\u3002<\/p>\n

\u80ba\u529f\u80fd\u969c\u788d<\/h2>\n

\u7531\u4e8e\u4eba\u7c7b\u514d\u75ab\u7cfb\u7edf\u5bf9\u75c5\u6bd2\u7684\u53cd\u5e94\uff0c\u51a0\u72b6\u75c5\u6bd2\u4f4f\u9662\u60a3\u8005\u901a\u5e38\u4f1a\u51fa\u73b0\u6025\u6027\u80ba\u529f\u80fd\u969c\u788d\u3002<\/p>\n

\u4eba\u4eec\u666e\u904d\u8ba4\u4e3a\uff0c\u8fd9\u79cd\u75be\u75c5\u5c06\u5bfc\u81f4\u6162\u6027\u80ba\u7ea4\u7ef4\u5316\uff0c\u7c7b\u4f3c\u4e8e\u4ee5\u524d\u7684\u4f20\u67d3\u6027\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\uff0c\u5982\u4e25\u91cd\u6025\u6027\u547c\u5438\u7efc\u5408\u5f81(SARS)\u548c\u4e2d\u4e1c\u547c\u5438\u7efc\u5408\u5f81(MERS)\u3002<\/p>\n

\u8fd9\u4e9b\u5e76\u53d1\u75c7\u53ef\u5bfc\u81f4\u751f\u6d3b\u8d28\u91cf\u5dee\uff0c\u6301\u7eed\u4f4f\u9662\u7684\u8981\u6c42\u9ad8\uff0c\u6700\u7ec8\u9884\u540e\u5dee\u3002<\/p>\n

\u6cbb\u7597\u9886\u57df<\/h2>\n

REMAP-CAP\u6709\u51e0\u4e2a\u73b0\u6709\u7684\u6cbb\u7597\u9886\u57df\uff0c\u5305\u62ec\u6297\u75c5\u6bd2\u3001\u514d\u75ab\u8c03\u8282\u548c\u514d\u75ab\u7403\u86cb\u767d\u6cbb\u7597\u3002<\/p>\n

\u7814\u7a76\u4eba\u5458\u6b63\u5728\u79ef\u6781\u5f00\u53d1\u4e00\u4e2a\u65b0\u7684\u9886\u57df\u6765\u7814\u7a76\u80be\u7d20\u8840\u7ba1\u7d27\u5f20\u7d20\u7cfb\u7edf\u6291\u5236\u7684\u5f71\u54cd\uff0c\u5176\u4e2d\u5305\u62ecDMX-200\u3002<\/p>\n

Webster\u535a\u58eb\u8bf4:\u201c\u9009\u62e9\u6211\u4eec\u7684\u836f\u7269\u662f\u57fa\u4e8e\u5f3a\u5927\u7684\u79d1\u5b66\u4f9d\u636e\u548c\u6cbb\u7597\u51a0\u72b6\u75c5\u6bd2\u76f8\u5173\u95ee\u9898\u7684\u72ec\u7279\u6f5c\u529b\u3002\u201d<\/p>\n

\u201c\u4e00\u65e6\u83b7\u5f97\u76d1\u7ba1\u90e8\u95e8\u7684\u6279\u51c6\uff0c\u5b83\u53ef\u80fd\u662f\u8fd9\u9879\u7814\u7a76\u4e2d\u552f\u4e00\u7684\u5c1a\u5728\u7814\u7a76\u9636\u6bb5\u7684\u65b0\u836f\uff0c\u56e0\u4e3a\u6240\u9009\u7684\u6240\u6709\u5176\u4ed6\u5019\u9009\u836f\u7269\u90fd\u662f\u5bf9\u73b0\u6709\u5df2\u6279\u51c6\u7684\u53ef\u80fd\u7528\u4e8eCOVID-19\u7684\u836f\u7269\u7684\u91cd\u65b0\u5229\u7528\u3002\u201d<\/p>\n

\u80be\u6cbb\u7597<\/h2>\n

DMX-200\u6700\u521d\u88ab\u5f00\u53d1\u4e3a\u4e00\u79cd\u80be\u810f\u7597\u6cd5\uff0c\u53ef\u901a\u8fc7\u963b\u65ad\u708e\u75c7\u4fe1\u53f7\u4f20\u5bfc\u5e76\u9650\u5236\u7ea4\u7ef4\u5316\u7684\u53d1\u4f5c\u6765\u51cf\u5c11\u708e\u75c7\u7ec6\u80de\u7684\u635f\u5bb3\u3002<\/p>\n

\u8fd9\u4e2a\u8fc7\u7a0b\u662f\u5728Harry Perkins\u533b\u5b66\u7814\u7a76\u5b66\u9662\u548c\u897f\u6fb3\u5927\u5229\u4e9a\u5927\u5b66\u7684\u4e00\u4e2a\u5b9e\u9a8c\u5ba4\u91cc\u53d1\u73b0\u7684\u3002<\/p>\n

Dimerix\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u4e24\u9879\u9488\u5bf9\u7cd6\u5c3f\u75c5\u80be\u75c5\u548c\u5c40\u7076\u8282\u6bb5\u6027\u80be\u5c0f\u7403\u786c\u5316\u7684\u4e8c\u671f\u7814\u7a76\u3002\u5c40\u7076\u8282\u6bb5\u6027\u80be\u5c0f\u7403\u786c\u5316\u662f\u4e00\u79cd\u5728\u80be\u810f\u8fc7\u6ee4\u8840\u6db2\u5e9f\u7269\u7684\u90e8\u4f4d\u5f62\u6210\u75a4\u75d5\u7ec4\u7ec7\u7684\u75be\u75c5<\/p>\n

\u8be5\u516c\u53f8\u8fd8\u62e5\u6709\u7528\u4e8e\u6cbb\u7597\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\u7684DMX-700\u4e34\u5e8a\u524d\u5f00\u53d1\u7684\u65b0\u8d44\u4ea7\u3002<\/p>\n

\u65e9\u76d8\u4e2d\u6bb5\uff0cDimerix\u80a1\u4ef7\u4e0a\u6da870.37%\uff0c\u81f30.46\u6fb3\u5143\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u4e34\u5e8a\u751f\u7269\u5236\u836f\u516c\u53f8Dimerix Limited (ASX: DXB)\u5f00\u53d1\u7684\u4e00\u79cd\u5019\u9009\u836f\u7269\u5df2\u88ab\u7eb3\u5165\u4e00\u9879\u5168\u7403\u7814\u7a76\uff0c\u8be5\u7814\u7a76\u65e8\u5728\u6cbb\u7597\u7531\u51a0\u72b6\u75c5\u6bd2\u5bfc\u81f4\u7684\u6025\u6027\u547c\u5438\u7a98\u8feb\u7efc\u5408\u5f81(ARDS)\u60a3\u8005\u3002 \u793e\u533a\u83b7\u5f97\u6027\u80ba\u708e\u968f\u673a\u3001\u5d4c\u5165\u5f0f\u3001\u591a\u56e0\u7d20\u81ea\u9002\u5e94\u5e73\u53f0\u8bd5\u9a8c(REMAP-CAP)\u9879\u76ee\u5c06\u4fa7\u91cd\u4e8e\u5bf9\u5df2\u8bc1\u5b9e\u6216\u7591\u4f3c\u51a0\u72b6\u75c5\u6bd2\u7684\u4f4f\u9662\u60a3\u8005\u7684\u591a\u79cd\u5e72\u9884\u63aa\u65bd\uff0c\u8fd9\u4e9b\u60a3\u8005\u5c06\u767b\u8bb0\u5728\u91cd\u75c7\u76d1\u62a4\u5ba4\u548c\u975e\u91cd\u75c7\u76d1\u62a4\u5ba4\u3002 \u9009\u62e9Dimerix\u7684\u7814\u53d1\u836f\u7269DMX-200\uff0c\u662f\u56e0\u4e3a\u5b83\u6709\u53ef\u80fd\u901a\u8fc7\u51cf\u5c11\u80ba\u90e8\u708e\u75c7\u53cd\u5e94\u3001\u51cf\u5c11\u708e\u75c7\u548c\u968f\u540e\u7684\u7ea4\u7ef4\u5316\u800c\u4f7fARDS\u60a3\u8005\u53d7\u76ca\u3002 \u6839\u636e\u76d1\u7ba1\u548c\u4f26\u7406\u65b9\u9762\u7684\u6279\u51c6\uff0cDimerix\u5c06\u4ece\u5176\u73b0\u6709\u7684\u836f\u54c1\u7ea7\u751f\u4ea7\u4f9b\u5e94\u4e2d\u63d0\u4f9b\u6570\u91cf\u7684\u836f\u7269\u3002 \u9664\u4e86\u5df2\u5728\u6240\u6709\u5173\u952e\u5730\u533a\u6388\u4e88\u7684CCR2\u6291\u5236\u5242(\u5305\u62ecDMX-200)\u6cbb\u7597ARDS\u7684\u4e13\u5229\u5916\uff0c\u8be5\u516c\u53f8\u8fd8\u63d0\u4ea4\u4e86\u4e34\u65f6\u4e13\u5229\u7533\u8bf7\u3002 \u4e34\u5e8a\u5f71\u54cd \u9996\u5e2d\u6267\u884c\u5b98Nina Webster\u535a\u58eb\u8bf4\uff0cDimerix\u975e\u5e38\u613f\u610f\u652f\u6301\u5168\u7403\u51a0\u72b6\u75c5\u6bd2\u6cbb\u7597\u5de5\u4f5c\u3002 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\u8fd9\u4e00\u6307\u5b9a\u786e\u4fdd\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u7684\u77e5\u8bc6\u8f6c\u5316\u53ef\u4ee5\u76f4\u63a5\u4e0e\u51b3\u7b56\u8005\u548c\u516c\u5171\u536b\u751f\u5b98\u5458\u8fdb\u884c\uff0c\u4ee5\u4fbf\u6839\u636e\u9700\u8981\u5728\u5168\u7403\u8fc5\u901f\u5b9e\u65bd\u3002 \u8be5\u7814\u7a76\u5df2\u88ab\u82f1\u56fd\u9996\u5e2d\u533b\u7597\u5b98\u6307\u5b9a\u4e3a\u51a0\u72b6\u75c5\u6bd2\u7684\u5173\u952e\u4e34\u5e8a\u8bd5\u9a8c\u3002 \u5c3d\u7ba1\u9002\u5e94\u6027\u7814\u7a76\u5f00\u59cb\u65f6\u7684\u5177\u4f53\u6570\u5b57\u5c1a\u672a\u660e\u786e\uff0c\u4f46\u8ba1\u5212\u5c06\u4e9a\u592a\u3001\u6b27\u6d32\u548c\u5317\u7f8e\u7684200\u4e2a\u5df2\u7ecf\u542f\u52a8\u7684\u7814\u7a76\u5730\u70b9\u76847000\u591a\u540d\u60a3\u8005\u7eb3\u5165\u7814\u7a76\u3002 \u80ba\u529f\u80fd\u969c\u788d 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