{"id":1747,"date":"2020-08-14T00:55:49","date_gmt":"2020-08-14T00:55:49","guid":{"rendered":"\/\/smallcapscn.x5view.co\/?p=1747"},"modified":"2023-08-29T17:46:32","modified_gmt":"2023-08-29T17:46:32","slug":"prescient-therapeutics-peter-maccallum-cancer-centre-advance-car-t-cancer-therapy","status":"publish","type":"post","link":"https:\/\/smallcapscn.x5view.co\/?p=1747","title":{"rendered":"Prescient Therapeutics\u4e0e Peter MacCallum Cancer Centre\u5408\u4f5c\uff0c\u5171\u540c\u63a8\u8fdbCAR-T\u764c\u75c7\u6cbb\u7597"},"content":{"rendered":"<p>\u5728\u900f\u9732\u4e86\u4e0e\u58a8\u5c14\u672c\u4e16\u754c\u8457\u540d\u7684Peter MacCallum Cancer Centre(Peter Mac)\u7684\u5408\u4f5c\u540e\uff0c<a href=\"http:\/\/smallcaps-production.test\/stocks\/?symbol=PTX&amp;lang=cn\">Prescient Therapeutics (ASX: PTX)<\/a>\u79bb\u7814\u53d1\u72ec\u7279\u7684CAR-T\u764c\u75c7\u6280\u672f\u66f4\u8fd1\u4e86\u4e00\u6b65\u3002<\/p>\n<p>\u9884\u8ba1\u6b64\u6b21\u5408\u4f5c\u5c06\u5229\u7528\u5148\u89c1\u4e4b\u660e\u7684\u4e13\u6709CAR-T\u764c\u75c7\u7597\u6cd5\uff0c\u5e76\u6269\u5927\u5176\u6295\u8d44\u7ec4\u5408\u3002<\/p>\n<p>\u636ePrescient Therapeutics\u4ecb\u7ecd\uff0c\u8be5\u516c\u53f8\u662fASX\u4e0a\u5e02\u516c\u53f8\u4e2d\u552f\u4e00\u62e5\u6709CAR-T\u6280\u672f\u7684\u80a1\u7968\u3002CAR-T\u6280\u672f\u662f\u4e00\u79cd\u7ec6\u80de\u7597\u6cd5\uff0c\u53ef\u4ee5\u5bf9\u764c\u75c7\u60a3\u8005\u7684\u514d\u75ab\u7ec6\u80de\u8fdb\u884c\u91cd\u65b0\u7f16\u7a0b\uff0c\u4ee5\u8bc6\u522b\u5e76\u6467\u6bc1\u764c\u75c7\u3002<\/p>\n<p>Peter Mac\u7684Phil 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Mac\u7684\u5408\u4f5c\u589e\u52a0\u4e86Prescient\u76ee\u524d\u7ec6\u80de\u6cbb\u7597\u589e\u5f3a(CTE)\u9879\u76ee\u7684\u7ba1\u9053\u3002<\/p>\n<p>\u53e6\u4e00\u4e2aCTE\u9879\u76ee\u6b63\u5728\u548cCarina Biotech\u4e00\u8d77\u8fdb\u884c\uff0c\u8fd9\u4e2a\u9879\u76ee\u548cPeter Mac\u7684\u7814\u7a76\u90fd\u65e8\u5728\u4ea7\u751f\u6280\u672f\u6765\u8865\u5145\u73b0\u6709\u7684CAR-T\u65b9\u6cd5\u3002<\/p>\n<p>\u8be5\u516c\u53f8\u8865\u5145\u8bf4\uff0cCTE\u7814\u7a76\u7684\u76ee\u7684\u662f\u5f00\u53d1\u529f\u6548\u548c\u63d0\u9ad8\u6548\u7387\uff0c\u4ee5\u5438\u5f15\u8be5\u9886\u57df\u7684\u7b2c\u4e09\u65b9\uff0c\u8fd9\u4e9b\u7b2c\u4e09\u65b9\u53ef\u80fd\u5728\u83b7\u5f97\u8bb8\u53ef\u540e\u5c06\u8be5\u6280\u672f\u7eb3\u5165\u4ed6\u4eec\u81ea\u5df1\u7684\u9879\u76ee\u3002<\/p>\n<p>\u201c\u6211\u4eec\u6b63\u5728\u4e3a\u8bb8\u591a\u764c\u75c7\u60a3\u8005\u4e89\u5206\u593a\u5229\uff0c\u6240\u4ee5\u52a0\u5165Peter Mac\u8fd9\u4e2a\u9886\u57df\u7684\u4e16\u754c\u9886\u5148\u4e13\u5bb6\u5c06\u6781\u5927\u5730\u52a0\u5f3a\u6211\u4eec\u7684\u96c6\u4f53\u52aa\u529b\uff0c\u4ee5\u63a8\u8fdb\u8fd9\u4e9b\u65b0\u7597\u6cd5\uff0c\u5e76\u5c06\u5176\u5e26\u7ed9\u90a3\u4e9b\u53ef\u80fd\u53d7\u76ca\u7684\u60a3\u8005\uff0c\u201d\u5177\u6709\u5148\u89c1\u4e4b\u660e\u7684\u9996\u5e2d\u6267\u884c\u5b98Steven Yatomi-Clarke\u8bf4\u3002<\/p>\n<p>\u4ed6\u8865\u5145\u8bf4:\u201cPrescient\u662fASX\u552f\u4e00\u4e00\u5bb6\u5f00\u53d1CAR-T\u9879\u76ee\u7684\u4e0a\u5e02\u516c\u53f8\uff0c\u8fd9\u662f\u8865\u5145\u6211\u4eec\u5728CTE\u9879\u76ee\u7684\u91cd\u8981\u6218\u7565\u4e3e\u63aa\u3002\u201d<\/p>\n<h2>\u764c\u75c7\u6cbb\u7597PTX-100<\/h2>\n<p>\u5728\u4eca\u5929\u5173\u4e8ePeter Mac\u7814\u7a76\u5408\u4f5c\u7684\u65b0\u95fb\u4e4b\u524d\uff0c\u672c\u5468\u65e9\u4e9b\u65f6\u5019Prescient\u8868\u660e\uff0c\u5176\u5bf9PTX-100\u836f\u7269\u7684\u7814\u7a76\u5df2\u7ecf\u53d6\u5f97\u8fdb\u5c55\u3002<\/p>\n<p>\u5728\u6210\u529f\u5b8c\u6210\u7b2c\u4e8c\u62791000 mg\/m2\u7684\u8bd5\u9a8c\u540e\uff0cPTX-100\u76841b\u671f\u6b63\u5728\u8fdb\u884c\u52302000 mg\/m2\u7684\u4e0b\u4e00\u4e2a\u5242\u91cf\u6c34\u5e73\u3002<\/p>\n<p>\u5728\u7b2c\u4e8c\u9879\u7814\u7a76\u4e2d\uff0c\u4e09\u540d\u60a3\u8005\u90fd\u662f\u665a\u671f\u80f0\u817a\u764c\u3001\u5916\u5468T\u7ec6\u80de\u6dcb\u5df4\u7624\u548c\u8840\u7ba1\u514d\u75ab\u6bcd\u7ec6\u80deT\u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u91cd\u5ea6\u9884\u5904\u7406\u60a3\u8005\u3002<\/p>\n<p>Prescient\u7684PTX-100\u662f\u4e00\u79cdRas\u901a\u8def\u6291\u5236\u5242\uff0c\u8bbe\u8ba1\u7528\u4e8e\u6700\u7ec8\u5bfc\u81f4\u764c\u7ec6\u80de\u6b7b\u4ea1\u3002<\/p>\n<p>\u8fd9\u98791b\u671f\u4e00\u63fd\u5b50\u7814\u7a76\u65e8\u5728\u786e\u5b9aPTX-100\u4f5c\u4e3a\u5355\u4e00\u836f\u5242\u5728Ras\u548cRhoA\u7a81\u53d8\u6d41\u884c\u7684\u51e0\u79cd\u764c\u75c7\u4e2d\u7684\u5b89\u5168\u6027\u3001\u5242\u91cf\u65b9\u6848\u548c\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n<p>\u5bf9\u63a5\u53d7500mg\/m2\u6cbb\u7597\u7684\u7b2c\u4e00\u6279\u60a3\u8005\u7684\u5206\u6790\u663e\u793a\uff0c\u4e24\u540d\u60a3\u8005\u7684\u75c5\u60c5\u7a33\u5b9a\uff0c\u90e8\u5206\u7f13\u89e3\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5728\u900f\u9732\u4e86\u4e0e\u58a8\u5c14\u672c\u4e16\u754c\u8457\u540d\u7684Peter MacCallum Cancer Centre(Peter Mac)\u7684\u5408\u4f5c\u540e\uff0cPrescient Therapeutics (ASX: PTX)\u79bb\u7814\u53d1\u72ec\u7279\u7684CAR-T\u764c\u75c7\u6280\u672f\u66f4\u8fd1\u4e86\u4e00\u6b65\u3002 \u9884\u8ba1\u6b64\u6b21\u5408\u4f5c\u5c06\u5229\u7528\u5148\u89c1\u4e4b\u660e\u7684\u4e13\u6709CAR-T\u764c\u75c7\u7597\u6cd5\uff0c\u5e76\u6269\u5927\u5176\u6295\u8d44\u7ec4\u5408\u3002 \u636ePrescient Therapeutics\u4ecb\u7ecd\uff0c\u8be5\u516c\u53f8\u662fASX\u4e0a\u5e02\u516c\u53f8\u4e2d\u552f\u4e00\u62e5\u6709CAR-T\u6280\u672f\u7684\u80a1\u7968\u3002CAR-T\u6280\u672f\u662f\u4e00\u79cd\u7ec6\u80de\u7597\u6cd5\uff0c\u53ef\u4ee5\u5bf9\u764c\u75c7\u60a3\u8005\u7684\u514d\u75ab\u7ec6\u80de\u8fdb\u884c\u91cd\u65b0\u7f16\u7a0b\uff0c\u4ee5\u8bc6\u522b\u5e76\u6467\u6bc1\u764c\u75c7\u3002 Peter Mac\u7684Phil Darcy\u6559\u6388\u5c06\u9886\u5bfc\u8fd9\u9879\u7814\u7a76\uff0c\u5e76\u6709Prescient\u62e5\u6709\u8be5\u9879\u76ee\u4ea7\u751f\u7684\u4efb\u4f55\u77e5\u8bc6\u4ea7\u6743\u3002 Darcy\u6559\u6388\u8868\u793a\uff0cCAR-T\u7597\u6cd5\u5728\u67d0\u4e9b\u8840\u6db2\u6076\u6027\u80bf\u7624\u4e2d\u663e\u793a\u51fa\u201c\u5f3a\u5927\u7684\u6cbb\u7597\u6d3b\u6027\u201d\u3002 \u7136\u800c\uff0c\u5b83\u5bf9\u5b9e\u4f53\u764c\u75c7\u7684\u5f71\u54cd\u5374\u6ca1\u6709\u90a3\u4e48\u5927\u3002 Darcy\u6559\u6388\u8865\u5145\u8bf4:\u201c\u6211\u4eec\u6b63\u5728\u63a2\u7d22\u7684\u6709\u9884\u89c1\u6027\u7684\u65b9\u6cd5\u53ef\u80fd\u4f1a\u91cd\u65b0\u7f16\u7a0b\u80bf\u7624\u5fae\u73af\u5883\uff0c\u4ece\u800c\u663e\u8457\u589e\u5f3aCAR-T\u7ec6\u80de\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u201d \u7ec6\u80de\u6cbb\u7597\u589e\u5f3a\u9879\u76ee \u4e0ePeter Mac\u7684\u5408\u4f5c\u589e\u52a0\u4e86Prescient\u76ee\u524d\u7ec6\u80de\u6cbb\u7597\u589e\u5f3a(CTE)\u9879\u76ee\u7684\u7ba1\u9053\u3002 \u53e6\u4e00\u4e2aCTE\u9879\u76ee\u6b63\u5728\u548cCarina Biotech\u4e00\u8d77\u8fdb\u884c\uff0c\u8fd9\u4e2a\u9879\u76ee\u548cPeter Mac\u7684\u7814\u7a76\u90fd\u65e8\u5728\u4ea7\u751f\u6280\u672f\u6765\u8865\u5145\u73b0\u6709\u7684CAR-T\u65b9\u6cd5\u3002 \u8be5\u516c\u53f8\u8865\u5145\u8bf4\uff0cCTE\u7814\u7a76\u7684\u76ee\u7684\u662f\u5f00\u53d1\u529f\u6548\u548c\u63d0\u9ad8\u6548\u7387\uff0c\u4ee5\u5438\u5f15\u8be5\u9886\u57df\u7684\u7b2c\u4e09\u65b9\uff0c\u8fd9\u4e9b\u7b2c\u4e09\u65b9\u53ef\u80fd\u5728\u83b7\u5f97\u8bb8\u53ef\u540e\u5c06\u8be5\u6280\u672f\u7eb3\u5165\u4ed6\u4eec\u81ea\u5df1\u7684\u9879\u76ee\u3002 \u201c\u6211\u4eec\u6b63\u5728\u4e3a\u8bb8\u591a\u764c\u75c7\u60a3\u8005\u4e89\u5206\u593a\u5229\uff0c\u6240\u4ee5\u52a0\u5165Peter Mac\u8fd9\u4e2a\u9886\u57df\u7684\u4e16\u754c\u9886\u5148\u4e13\u5bb6\u5c06\u6781\u5927\u5730\u52a0\u5f3a\u6211\u4eec\u7684\u96c6\u4f53\u52aa\u529b\uff0c\u4ee5\u63a8\u8fdb\u8fd9\u4e9b\u65b0\u7597\u6cd5\uff0c\u5e76\u5c06\u5176\u5e26\u7ed9\u90a3\u4e9b\u53ef\u80fd\u53d7\u76ca\u7684\u60a3\u8005\uff0c\u201d\u5177\u6709\u5148\u89c1\u4e4b\u660e\u7684\u9996\u5e2d\u6267\u884c\u5b98Steven Yatomi-Clarke\u8bf4\u3002 \u4ed6\u8865\u5145\u8bf4:\u201cPrescient\u662fASX\u552f\u4e00\u4e00\u5bb6\u5f00\u53d1CAR-T\u9879\u76ee\u7684\u4e0a\u5e02\u516c\u53f8\uff0c\u8fd9\u662f\u8865\u5145\u6211\u4eec\u5728CTE\u9879\u76ee\u7684\u91cd\u8981\u6218\u7565\u4e3e\u63aa\u3002\u201d \u764c\u75c7\u6cbb\u7597PTX-100 \u5728\u4eca\u5929\u5173\u4e8ePeter Mac\u7814\u7a76\u5408\u4f5c\u7684\u65b0\u95fb\u4e4b\u524d\uff0c\u672c\u5468\u65e9\u4e9b\u65f6\u5019Prescient\u8868\u660e\uff0c\u5176\u5bf9PTX-100\u836f\u7269\u7684\u7814\u7a76\u5df2\u7ecf\u53d6\u5f97\u8fdb\u5c55\u3002 \u5728\u6210\u529f\u5b8c\u6210\u7b2c\u4e8c\u62791000 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