{"id":3611,"date":"2021-08-08T23:07:38","date_gmt":"2021-08-08T23:07:38","guid":{"rendered":"\/\/smallcapscn.x5view.co\/?p=3611"},"modified":"2023-08-29T18:01:46","modified_gmt":"2023-08-29T18:01:46","slug":"prescient-therapeutics-2021-funded-advance-cancer-fighting-therapies","status":"publish","type":"post","link":"https:\/\/smallcapscn.x5view.co\/?p=3611","title":{"rendered":"\u5728\u7ecf\u5386\u4e86\u201c\u5de8\u5927\u7684\u201d2021\u8d22\u5e74\u4e4b\u540e\uff0cPrescient Therapeutics\u83b7\u5f97\u4e86\u5927\u91cf\u8d44\u91d1\u6765\u63a8\u8fdb\u6297\u764c\u7597\u6cd5"},"content":{"rendered":"

\u4e34\u5e8a\u9636\u6bb5\u80bf\u7624\u516c\u53f8Prescient Therapeutics (ASX: PTX)\u5f3a\u52b2\u7684\u73b0\u91d1\u72b6\u51b5\u5c06\u4f7f\u5176\u80fd\u591f\u63a8\u8fdb\u591a\u79cd\u764c\u75c7\u9879\u76ee\uff0c\u5e76\u5728\u8463\u4e8b\u603b\u7ecf\u7406Steven Yatomi-Clarke\u6240\u8bf4\u7684\u201c\u5de8\u5927\u201d\u76842021\u8d22\u5e74\u7ee7\u7eed\u52aa\u529b\u3002<\/p>\n

\u8be5\u516c\u53f8\u5f00\u53d1\u4e2a\u6027\u5316\u7684\u764c\u75c7\u6cbb\u7597\u65b9\u6cd5\uff0c\u5305\u62ec\u9776\u5411\u548c\u7ec6\u80de\u7597\u6cd5\u3002<\/p>\n

OmniCAR\u662f\u4e00\u79cd\u901a\u7528\u514d\u75ab\u53d7\u4f53\u5e73\u53f0\uff0c\u6b63\u5728\u5f00\u53d1\u4e0b\u4e00\u4ee3CAR-T\u6cbb\u7597\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u3001her2\u9633\u6027\u5b9e\u4f53\u80bf\u7624(\u5305\u62ec\u4e73\u817a\u764c\u3001\u5375\u5de2\u764c\u548c\u80c3\u764c)\u3002\u591a\u5f62\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624(\u8111\u764c)\u3002<\/p>\n

Prescient\u5728\u6fb3\u5927\u5229\u4e9a\u548c\u7f8e\u56fd\u7684\u7814\u53d1\u6d3b\u52a8\u4e0a\u6295\u5165\u4e8628\u4e07\u6fb3\u5143\uff0c\u7279\u522b\u662f\u4e0eOmniCAR\u548c\u7ec6\u80de\u6cbb\u7597\u589e\u5f3a\u76f8\u5173\u7684\u7814\u53d1\uff0c\u4ee5\u53ca\u6b63\u5728\u8fdb\u884c\u7684PTX-100\u548cPTX-200\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u622a\u81f36\u6708\u5f53\u5b63\uff0cPrescient\u7684\u73b0\u91d1\u50a8\u5907\u4e3a1610\u4e07\u6fb3\u5143\u3002<\/p>\n

\u8fd1\u671f\u53d6\u5f97\u7684\u6210\u5c31\u5305\u62ec:6\u670830\u65e5\u4e4b\u540e\u5ba3\u5e03\u7684PTX-100 1b\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6210\u529f\u7ed3\u679c\uff0c\u8fd9\u5bfc\u81f4\u4e86\u5bf9\u6cbb\u7597T\u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u5019\u9009\u836f\u7269\u7684\u6269\u5c55\u7814\u7a76\uff0c\u4ee5\u53caOmniCAR\u5e73\u53f0\u5f00\u53d1\u7684\u8bd5\u9a8c\u548c\u5236\u9020\u91cc\u7a0b\u7891\u3002<\/p>\n

PTX-100\u8bd5\u9a8c\u8fdb\u5c55<\/h2>\n

7\u6708\u5e95\uff0cPrescient\u62a5\u9053\u4e86PTX-100 1b\u671f\u7bee\u5b50\u8bd5\u9a8c\u5728\u5b9e\u4f53\u764c\u548c\u8840\u6db2\u764c\u4e2d\u7684\u7ed3\u679c\uff0c\u8868\u660e\u8be5\u836f\u7269\u5728\u6240\u6709\u5242\u91cf\u6c34\u5e73\u4e0a\u90fd\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002<\/p>\n

\u5728\u4e24\u540d\u6709\u4fb5\u88ad\u6027\u75be\u75c5\u7684\u60a3\u8005\u4e2d\u4e5f\u89c2\u5bdf\u5230\u65e9\u671f\u4e34\u5e8a\u6d3b\u52a8\uff0c\u5728\u8fd9\u4e24\u540d\u60a3\u8005\u4e2d\uff0c\u5148\u524d\u7684\u6cbb\u7597\u672a\u80fd\u963b\u6b62\u5176\u8fdb\u5c55\u3002\u5176\u4e2d\u4e00\u540d\u60a3\u8005\u7ecf\u5386\u4e86\u6cbb\u7597\u7684\u90e8\u5206\u53cd\u5e94(\u764c\u75c7\u8d1f\u62c5\u7684\u51cf\u5c11)\uff0c\u8fc4\u4eca\u4e3a\u6b6217\u4e2a\u6708\u6ca1\u6709\u75be\u75c5\u8fdb\u5c55\uff0c\u800c\u53e6\u4e00\u540d\u60a3\u8005\u7ecf\u5386\u4e86\u764c\u75c7\u75c5\u7076\u7684\u51cf\u5c11\u548c\u75c7\u72b6\u3002<\/p>\n

Prescient\u62a5\u9053\u8bf4:\u201c\u5728\u8fd9\u4e24\u79cd\u60c5\u51b5\u4e0b\uff0c\u63a5\u53d7\u6807\u51c6\u62a4\u7406\u6cbb\u7597\u7684\u96be\u6cbb\u6027T\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u901a\u5e38\u4f1a\u57284\u4e2a\u6708\u5185\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\uff0c\u8fd9\u7a81\u51fa\u4e86\u8fd9\u4e9b\u53cd\u5e94\u7684\u4ee4\u4eba\u9f13\u821e\u7684\u6027\u8d28\u3002\u201d<\/p>\n

\u7531\u4e8e\u8fd9\u4e9b\u4ee4\u4eba\u9f13\u821e\u76841b\u671f\u7814\u7a76\u7ed3\u679c\uff0c\u8be5\u516c\u53f8\u76ee\u524d\u6b63\u5728\u5bf9\u590d\u53d1\u548c\u96be\u6cbb\u6027T\u7ec6\u80de\u6dcb\u5df4\u7624\u8fdb\u884c\u6269\u5c55\u961f\u5217\u7814\u7a76\uff0c\u5c06PTX-100\u4f5c\u4e3a\u5355\u836f\u6cbb\u7597\u3002<\/p>\n

\u5982\u679c\u6269\u5c55\u961f\u5217\u8bd5\u9a8c\u6210\u529f\uff0cPrescient\u53ef\u4ee5\u76f4\u63a5\u8fdb\u5165\u5355\u72ec\u7684\u6ce8\u518c\u7814\u7a76\uff0c\u4e0e\u5178\u578b\u7684\u4e09\u671f\u8bd5\u9a8c\u76f8\u6bd4\uff0c\u8fd9\u53ef\u80fd\u53ea\u9700\u8981\u5c0f\u578b\u8bd5\u9a8c\u3002<\/p>\n

Prescient\u7684\u53e6\u4e00\u79cd\u9776\u5411\u7597\u6cd5PTX-200\u76ee\u524d\u6b63\u5728\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u4e2d\u8fdb\u884c1b\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u8fd9\u9879\u7814\u7a76\u7684\u6700\u65b0\u8fdb\u5c55\u9884\u8ba1\u5c06\u5728\u672a\u6765\u51e0\u4e2a\u6708\u516c\u5e03\u3002<\/p>\n

OmniCAR\u91cc\u7a0b\u7891<\/h2>\n

\u4e3a\u4e86\u52a0\u5feb\u5176OmniCAR\u91cc\u7a0b\u7891\uff0cPrescient\u57286\u6708\u5b63\u5ea6\u6269\u5927\u4e86\u4e0e\u4e16\u754c\u8457\u540d\u7684Peter MacCallum\u764c\u75c7\u4e2d\u5fc3\u7684\u7814\u7a76\u5408\u4f5c\u5173\u7cfb\u3002<\/p>\n

\u8be5\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\u5c06\u5feb\u901f\u53d1\u5c55Prescient\u7684\u4e0b\u4e00\u4ee3CAR-T\u6cbb\u7597\u4f7f\u7528OmniCAR\u5e73\u53f0\u3002<\/p>\n

\u6700\u8fd1\u8fd8\u5ba3\u5e03\u4e86OmniCAR\u5173\u952e\u7ed3\u5408\u6210\u5206SpyTag\u548cSpyCatcher\u7684\u72ec\u7acb\u7845\u514d\u75ab\u539f\u6027\u6d4b\u8bd5\u7684\u201c\u5353\u8d8a\u201d\u7ed3\u679c\u3002<\/p>\n

\u8be5\u516c\u53f8\u8868\u793a\uff0c\u8fd9\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u91cc\u7a0b\u7891\uff0c\u6781\u5927\u5730\u964d\u4f4e\u4e86\u6574\u4e2a\u5e73\u53f0\u7684\u98ce\u9669\uff0c\u5bf9\u63a8\u8fdbprecient\u5185\u90e8\u9879\u76ee\u548c\u5916\u90e8\u5408\u4f5c\u975e\u5e38\u91cd\u8981\u3002<\/p>\n

\u514d\u75ab\u539f\u6027\u6d4b\u8bd5\u8bc4\u4f30\u5bf9\u65b0\u7597\u6cd5\u7684\u514d\u75ab\u53cd\u5e94\u3002\u5728CAR-T\u7ec6\u80de\u6cbb\u7597\u7684\u60c5\u51b5\u4e0b\uff0c\u9ad8\u6c34\u5e73\u7684\u514d\u75ab\u539f\u6027\u4f1a\u5bf9CAR-T\u7ec6\u80de\u7684\u6269\u5c55\u548c\u6301\u4e45\u6027\u4ea7\u751f\u4e0d\u5229\u5f71\u54cd\uff0c\u4ece\u800c\u5f71\u54cd\u6cbb\u7597\u7684\u6574\u4f53\u5b89\u5168\u6027\u548c\u4e34\u5e8a\u53cd\u5e94\u3002<\/p>\n

OmniCAR\u7684\u7ed3\u5408\u7cfb\u7edf\u7ec4\u4ef6SpyTag\u548cSpyCatcher\u7531\u4e00\u5bb6\u7f8e\u56fd\u7814\u7a76\u4f9b\u5e94\u5546\u72ec\u7acb\u6d4b\u8bd5\uff0c\u7ed3\u679c\u8868\u660e\uff0c\u8fd9\u4e24\u79cd\u7ec4\u4ef6\u7684\u514d\u75ab\u539f\u6027\u90fd\u975e\u5e38\u4f4e\u2014\u2014\u4e0e\u5faa\u73af\u4e2d\u7684\u4eba\u7c7b\u6297\u4f53\u76f8\u5f53\u3002<\/p>\n

\u6709\u5148\u89c1\u4e4b\u660e\u7684\u9996\u5e2d\u6267\u884c\u5b98\u517c\u8463\u4e8b\u603b\u7ecf\u7406Steven Yatomi-Clarke\u8868\u793a\uff0c\u7ed3\u679c\u201c\u597d\u5f97\u4e0d\u80fd\u518d\u597d\u4e86\u201d\u3002<\/p>\n

\u201c\u8fd9\u7ed9\u4e86\u6211\u4eec\u4fe1\u5fc3\uff0c\u5982\u679c\u8fd9\u4e9b\u7597\u6cd5\u6700\u7ec8\u88ab\u5e94\u7528\u5230\u60a3\u8005\u8eab\u4e0a\uff0c\u4ed6\u4eec\u7684\u514d\u75ab\u7cfb\u7edf\u4e0d\u4f1a\u635f\u5bb3\u6cbb\u7597\u672c\u8eab\u3002\u201d<\/p>\n

\u4ed6\u8865\u5145\u8bf4:\u201c\u8fd9\u4e0d\u4ec5\u5bf9Prescient\u516c\u53f8\u7684\u4e09\u4e2a\u5185\u90e8OmniCAR\u9879\u76ee\u81f3\u5173\u91cd\u8981\uff0c\u5bf9\u6f5c\u5728\u7684\u5916\u90e8\u5408\u4f5c\u8005\u4e5f\u662f\u5982\u6b64\uff0c\u4ed6\u4eec\u975e\u5e38\u4e25\u683c\u5730\u8003\u8651\u514d\u75ab\u539f\u6027\u3002\u201d<\/p>\n

OmniCAR\u5e73\u53f0\u5173\u952e\u7ec4\u4ef6\u7684\u5236\u9020\u548c\u4ea4\u4ed8\u6210\u529f\u5b8c\u6210\uff0c\u5305\u62ec\u7528\u4e8e\u51e0\u79cd\u764c\u75c7\u9776\u70b9\u7684\u7ec6\u80de\u7ed3\u5408\u5242\u548c\u7528\u4e8e\u751f\u4ea7CAR-T\u7ec6\u80de\u7684\u6162\u75c5\u6bd2\u8f7d\u4f53\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u4e34\u5e8a\u9636\u6bb5\u80bf\u7624\u516c\u53f8Prescient Therapeutics (ASX: PTX)\u5f3a\u52b2\u7684\u73b0\u91d1\u72b6\u51b5\u5c06\u4f7f\u5176\u80fd\u591f\u63a8\u8fdb\u591a\u79cd\u764c\u75c7\u9879\u76ee\uff0c\u5e76\u5728\u8463\u4e8b\u603b\u7ecf\u7406Steven Yatomi-Clarke\u6240\u8bf4\u7684\u201c\u5de8\u5927\u201d\u76842021\u8d22\u5e74\u7ee7\u7eed\u52aa\u529b\u3002 \u8be5\u516c\u53f8\u5f00\u53d1\u4e2a\u6027\u5316\u7684\u764c\u75c7\u6cbb\u7597\u65b9\u6cd5\uff0c\u5305\u62ec\u9776\u5411\u548c\u7ec6\u80de\u7597\u6cd5\u3002 OmniCAR\u662f\u4e00\u79cd\u901a\u7528\u514d\u75ab\u53d7\u4f53\u5e73\u53f0\uff0c\u6b63\u5728\u5f00\u53d1\u4e0b\u4e00\u4ee3CAR-T\u6cbb\u7597\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u3001her2\u9633\u6027\u5b9e\u4f53\u80bf\u7624(\u5305\u62ec\u4e73\u817a\u764c\u3001\u5375\u5de2\u764c\u548c\u80c3\u764c)\u3002\u591a\u5f62\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624(\u8111\u764c)\u3002 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