{"id":470,"date":"2020-04-22T02:05:43","date_gmt":"2020-04-22T02:05:43","guid":{"rendered":"\/\/smallcapscn.x5view.co\/?p=470"},"modified":"2023-08-29T17:44:59","modified_gmt":"2023-08-29T17:44:59","slug":"prescient-therapeutics-proceeds-next-stage-trial-patients-advanced-cancers","status":"publish","type":"post","link":"https:\/\/smallcapscn.x5view.co\/?p=470","title":{"rendered":"Prescient Therapeutics\u4e3a\u6709\u665a\u671f\u764c\u75c7\u7684\u60a3\u8005\u8fdb\u5c55\u5230\u4e0b\u4e00\u9636\u6bb5\u7684PTX-100\u836f\u7269\u8bd5\u9a8c"},"content":{"rendered":"

\u4e34\u5e8a\u671f\u80bf\u7624\u516c\u53f8Prescient Therapeutics (ASX: PTX)\u5df2\u786e\u8ba4\u5176\u764c\u75c7\u836f\u7269PTX-100\u76841b\u671f\u7bee\u5f0f\u7814\u7a76\u5c06\u5728\u7b2c\u4e00\u6279\u60a3\u8005\u6210\u529f\u5b8c\u6210\u5e76\u8fbe\u5230\u53ef\u63a5\u53d7\u7684\u5b89\u5168\u53c2\u6570\u540e\u8fdb\u5165\u4e0b\u4e00\u4e2a\u5242\u91cf\u6c34\u5e73\u3002<\/p>\n

\u58a8\u5c14\u672cEpworth\u533b\u9662\u7684\u5f00\u653e\u6807\u7b7e\u3001\u975e\u968f\u673a\u7814\u7a76\u65e8\u5728\u8bc4\u4f30PTX-100\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u836f\u6548\u5b66\uff0c\u4ee5\u53ca\u591a\u8fbe\u4e09\u79cd\u4e0d\u540c\u5242\u91cf\u7684PTX-100\u5728Ras\u548cRhoA\u86cb\u767d\u7a81\u53d8\u666e\u904d\u7684\u665a\u671f\u6076\u6027\u80bf\u7624\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n

\u8be5\u7814\u7a76\u91c7\u7528\u201c\u7bee\u5b50\u201d\u65b9\u6cd5\u6765\u8bc4\u4f30\u836f\u7269\u5bf9\u591a\u79cd\u764c\u75c7\u7684\u4f5c\u7528\uff0c\u4ee5\u89e3\u51b3\u7279\u5b9a\u7684\u7a81\u53d8\uff0c\u800c\u4e0d\u662f\u80bf\u7624\u8d77\u6e90\u3002<\/p>\n

\u7531\u51e0\u5bb6\u7f8e\u56fd\u516c\u53f8\u7387\u5148\u5f00\u5c55\u7684\u7bee\u5f0f\u7814\u7a76\uff0c\u5df2\u8fc5\u901f\u8bc6\u522b\u51fa\u53ef\u80fd\u53d7\u76ca\u4e8e\u8fd9\u79cd\u6b63\u5728\u7814\u7a76\u7684\u836f\u7269\u7684\u60a3\u8005\u7fa4\u4f53\uff0c\u6709\u65f6\u4f1a\u5bfc\u81f4\u5feb\u901f\u5ba1\u6279\u3002<\/p>\n

\u7f8e\u56fd\u65e9\u671f\u5bf9\u665a\u671f\u5b9e\u4f53\u80bf\u7624\u60a3\u8005\u7684\u7814\u7a76\u663e\u793a\uff0cPTX-100\u8010\u53d7\u6027\u826f\u597d\uff0c\u75c5\u60c5\u7a33\u5b9a\u3002<\/p>\n

\u9636\u6bb51b\u7ec4<\/h2>\n

PTX-100\u662f\u4e00\u7c7b\u836f\u7269\u5019\u9009\uff0c\u901a\u8fc7\u6291\u5236Rho\u3001Rac\u548cRal\u86cb\u767d\u7684\u6fc0\u6d3b\uff0c\u963b\u65ad\u81f4\u764cRas\u901a\u8def\uff0c\u5bfc\u81f4\u764c\u7ec6\u80de\u6b7b\u4ea1\u3002<\/p>\n

1b\u671f\u7814\u7a76\u961f\u5217\u4e2d\u76843\u540d\u60a3\u8005\u90fd\u7ecf\u8fc7\u4e86\u5927\u91cf\u7684\u9884\u5904\u7406\uff0c\u5e76\u60a3\u6709\u665a\u671f\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3001\u76ae\u80a4T\u7ec6\u80de\u6dcb\u5df4\u7624\u548c\u5468\u56f4t\u7ec6\u80de\u6dcb\u5df4\u7624\uff0c\u8fd9\u4e9b\u75be\u75c5\u4ee5\u524d\u90fd\u88ab\u5f52\u7c7b\u4e3a\u96be\u4ee5\u6cbb\u7597\u3002<\/p>\n

\u60a3\u8005\u63a5\u53d7500mg\/m2\u5242\u91cf\u7684PTX100\uff0c\u672a\u89c2\u5bdf\u5230\u4e0e\u836f\u7269\u76f8\u5173\u7684\u5b89\u5168\u95ee\u9898\u3002<\/p>\n

\u5242\u91cf\u5347\u7ea7<\/h2>\n

\u6839\u636e\u89c2\u5bdf\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u7684\u5b89\u5168\u76d1\u6d4b\u59d4\u5458\u4f1a\u5df2\u7ecf\u5141\u8bb8PTX-100\u8bd5\u9a8c\u7684\u5242\u91cf\u4e3a1000mg\/m2\u3002<\/p>\n

\u60a3\u8005\u572814\u5929\u7684\u5468\u671f\u4e2d\uff0c1 – 5\u5929\u5185\u9759\u8109\u8f93\u6db260\u5206\u949f\u4ee5\u4e0a\uff0c\u51714\u4e2a\u5468\u671f\uff0c\u9664\u975e\u89c2\u5bdf\u5230\u6bd2\u6027\u3002<\/p>\n

\u76ee\u7684\u662f\u786e\u5b9a\u6700\u4f73\u65f6\u95f4\u548c\u5242\u91cf\u4f9d\u8d56\u7684\u5f71\u54cd\uff0c\u591a\u5242\u91cf\u7684\u836f\u7269\u3002<\/p>\n

Prescient\u8bd5\u56fe\u8bc6\u522b\u6bcf\u4f4d\u60a3\u8005\u6076\u6027\u80bf\u7624\u7684\u7a81\u53d8\u72b6\u6001\uff0c\u5e76\u5728\u5c0f\u6837\u672c\u8303\u56f4\u5185\uff0c\u8bd5\u56fe\u5c06\u8fd9\u79cd\u72b6\u6001\u4e0e\u4efb\u4f55\u4e34\u5e8a\u6d3b\u52a8\u8054\u7cfb\u8d77\u6765\u3002<\/p>\n

\u4e00\u4e9b\u764c\u75c7\u751f\u7269\u6807\u8bb0\u7269\u5c06\u88ab\u7814\u7a76\uff0c\u76ee\u7684\u662f\u8bc6\u522b\u6700\u6709\u53ef\u80fd\u5bf9PTX-100\u6cbb\u7597\u4ea7\u751f\u53cd\u5e94\u7684\u60a3\u8005\u3002<\/p>\n

\u65b0\u7684\u8bd5\u9a8c\u7ad9\u70b9<\/h2>\n

Prescient\u4e0b\u4e00\u9636\u6bb5\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u7ecf\u6269\u5927\u5230\u5305\u62ec\u80bf\u7624\u5b66\u4e13\u4e1a\u5b9e\u8df5PASO\u533b\u7597\uff0c\u4f4d\u4e8e\u7ef4\u591a\u5229\u4e9a\u5dde\u4e1c\u5357\u90e8\u3002<\/p>\n

\u8be5\u516c\u53f8\u9884\u8ba1\uff0cPASO\u5bf9\u5b9e\u4f53\u80bf\u7624\u7684\u5173\u6ce8\u5c06\u8865\u5145Epworth\u533b\u9662\u7684\u8840\u6db2\u5b66\u764c\u75c7\u4e13\u4e1a\u77e5\u8bc6\uff0c\u5e76\u589e\u52a0PTX-100\u7814\u7a76\u62db\u52df\u7684\u764c\u75c7\u7c7b\u578b\u7684\u591a\u6837\u6027\u3002<\/p>\n

\u6709\u524d\u9014\u7684\u53d1\u5c55<\/h2>\n

Prescient\u7684\u8463\u4e8b\u603b\u7ecf\u7406Steve Yatomi-Clarke\u8bf4\uff0cPTX-100\u5242\u91cf\u589e\u52a0\u662f\u4e00\u4e2a\u6709\u524d\u9014\u7684\u53d1\u5c55\u3002<\/p>\n

\u4ed6\u8bf4:\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u770b\u5230\u7b2c\u4e00\u4e2a\u961f\u5217\u7684\u5b89\u5168\u6027\uff0c\u5b83\u5bfc\u81f4\u4e86PTX-100\u7684\u5242\u91cf\u589e\u52a0\uff0c\u7279\u522b\u662f\u5728\u4e25\u91cd\u9884\u5148\u6cbb\u7597\u7684\u665a\u671f\u764c\u75c7\u60a3\u8005\u4e2d\u3002\u201d<\/p>\n

\u201c\u5728\u8fc7\u53bb\u768412\u4e2a\u6708\u91cc\uff0cRas\u901a\u8def\u4e00\u76f4\u5907\u53d7\u5173\u6ce8\uff0c\u53d7\u5230\u533b\u5b66\u754c\u548c\u836f\u5b66\u754c\u7684\u5e7f\u6cdb\u5173\u6ce8\u3002\u6211\u4eec\u76f8\u4fe1\uff0c\u8fd9\u9879\u7814\u7a76\u7684\u7ed3\u679c\u2014\u2014\u5c24\u5176\u662f\u4f5c\u4e3a\u4e00\u79cd\u72ec\u7279\u7684\u3001\u4e00\u6d41\u7684\u8be5\u901a\u8def\u6291\u5236\u5242\u2014\u2014\u5c06\u503c\u5f97\u5173\u6ce8\u3002\u201d<\/p>\n

\u622a\u81f3\u5348\u76d8\uff0cPrescient\u80a1\u4ef7\u4e0a\u6da811.43%\uff0c\u81f30.039\u6fb3\u5143\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u4e34\u5e8a\u671f\u80bf\u7624\u516c\u53f8Prescient Therapeutics (ASX: PTX)\u5df2\u786e\u8ba4\u5176\u764c\u75c7\u836f\u7269PTX-100\u76841b\u671f\u7bee\u5f0f\u7814\u7a76\u5c06\u5728\u7b2c\u4e00\u6279\u60a3\u8005\u6210\u529f\u5b8c\u6210\u5e76\u8fbe\u5230\u53ef\u63a5\u53d7\u7684\u5b89\u5168\u53c2\u6570\u540e\u8fdb\u5165\u4e0b\u4e00\u4e2a\u5242\u91cf\u6c34\u5e73\u3002 \u58a8\u5c14\u672cEpworth\u533b\u9662\u7684\u5f00\u653e\u6807\u7b7e\u3001\u975e\u968f\u673a\u7814\u7a76\u65e8\u5728\u8bc4\u4f30PTX-100\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u836f\u6548\u5b66\uff0c\u4ee5\u53ca\u591a\u8fbe\u4e09\u79cd\u4e0d\u540c\u5242\u91cf\u7684PTX-100\u5728Ras\u548cRhoA\u86cb\u767d\u7a81\u53d8\u666e\u904d\u7684\u665a\u671f\u6076\u6027\u80bf\u7624\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002 \u8be5\u7814\u7a76\u91c7\u7528\u201c\u7bee\u5b50\u201d\u65b9\u6cd5\u6765\u8bc4\u4f30\u836f\u7269\u5bf9\u591a\u79cd\u764c\u75c7\u7684\u4f5c\u7528\uff0c\u4ee5\u89e3\u51b3\u7279\u5b9a\u7684\u7a81\u53d8\uff0c\u800c\u4e0d\u662f\u80bf\u7624\u8d77\u6e90\u3002 \u7531\u51e0\u5bb6\u7f8e\u56fd\u516c\u53f8\u7387\u5148\u5f00\u5c55\u7684\u7bee\u5f0f\u7814\u7a76\uff0c\u5df2\u8fc5\u901f\u8bc6\u522b\u51fa\u53ef\u80fd\u53d7\u76ca\u4e8e\u8fd9\u79cd\u6b63\u5728\u7814\u7a76\u7684\u836f\u7269\u7684\u60a3\u8005\u7fa4\u4f53\uff0c\u6709\u65f6\u4f1a\u5bfc\u81f4\u5feb\u901f\u5ba1\u6279\u3002 \u7f8e\u56fd\u65e9\u671f\u5bf9\u665a\u671f\u5b9e\u4f53\u80bf\u7624\u60a3\u8005\u7684\u7814\u7a76\u663e\u793a\uff0cPTX-100\u8010\u53d7\u6027\u826f\u597d\uff0c\u75c5\u60c5\u7a33\u5b9a\u3002 \u9636\u6bb51b\u7ec4 PTX-100\u662f\u4e00\u7c7b\u836f\u7269\u5019\u9009\uff0c\u901a\u8fc7\u6291\u5236Rho\u3001Rac\u548cRal\u86cb\u767d\u7684\u6fc0\u6d3b\uff0c\u963b\u65ad\u81f4\u764cRas\u901a\u8def\uff0c\u5bfc\u81f4\u764c\u7ec6\u80de\u6b7b\u4ea1\u3002 1b\u671f\u7814\u7a76\u961f\u5217\u4e2d\u76843\u540d\u60a3\u8005\u90fd\u7ecf\u8fc7\u4e86\u5927\u91cf\u7684\u9884\u5904\u7406\uff0c\u5e76\u60a3\u6709\u665a\u671f\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3001\u76ae\u80a4T\u7ec6\u80de\u6dcb\u5df4\u7624\u548c\u5468\u56f4t\u7ec6\u80de\u6dcb\u5df4\u7624\uff0c\u8fd9\u4e9b\u75be\u75c5\u4ee5\u524d\u90fd\u88ab\u5f52\u7c7b\u4e3a\u96be\u4ee5\u6cbb\u7597\u3002 \u60a3\u8005\u63a5\u53d7500mg\/m2\u5242\u91cf\u7684PTX100\uff0c\u672a\u89c2\u5bdf\u5230\u4e0e\u836f\u7269\u76f8\u5173\u7684\u5b89\u5168\u95ee\u9898\u3002 \u5242\u91cf\u5347\u7ea7 \u6839\u636e\u89c2\u5bdf\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u7684\u5b89\u5168\u76d1\u6d4b\u59d4\u5458\u4f1a\u5df2\u7ecf\u5141\u8bb8PTX-100\u8bd5\u9a8c\u7684\u5242\u91cf\u4e3a1000mg\/m2\u3002 \u60a3\u8005\u572814\u5929\u7684\u5468\u671f\u4e2d\uff0c1 – 5\u5929\u5185\u9759\u8109\u8f93\u6db260\u5206\u949f\u4ee5\u4e0a\uff0c\u51714\u4e2a\u5468\u671f\uff0c\u9664\u975e\u89c2\u5bdf\u5230\u6bd2\u6027\u3002 \u76ee\u7684\u662f\u786e\u5b9a\u6700\u4f73\u65f6\u95f4\u548c\u5242\u91cf\u4f9d\u8d56\u7684\u5f71\u54cd\uff0c\u591a\u5242\u91cf\u7684\u836f\u7269\u3002 Prescient\u8bd5\u56fe\u8bc6\u522b\u6bcf\u4f4d\u60a3\u8005\u6076\u6027\u80bf\u7624\u7684\u7a81\u53d8\u72b6\u6001\uff0c\u5e76\u5728\u5c0f\u6837\u672c\u8303\u56f4\u5185\uff0c\u8bd5\u56fe\u5c06\u8fd9\u79cd\u72b6\u6001\u4e0e\u4efb\u4f55\u4e34\u5e8a\u6d3b\u52a8\u8054\u7cfb\u8d77\u6765\u3002 \u4e00\u4e9b\u764c\u75c7\u751f\u7269\u6807\u8bb0\u7269\u5c06\u88ab\u7814\u7a76\uff0c\u76ee\u7684\u662f\u8bc6\u522b\u6700\u6709\u53ef\u80fd\u5bf9PTX-100\u6cbb\u7597\u4ea7\u751f\u53cd\u5e94\u7684\u60a3\u8005\u3002 \u65b0\u7684\u8bd5\u9a8c\u7ad9\u70b9 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