{"id":4727,"date":"2022-02-28T00:32:05","date_gmt":"2022-02-28T00:32:05","guid":{"rendered":"\/\/smallcapscn.x5view.co\/?p=4727"},"modified":"2023-08-29T17:53:09","modified_gmt":"2023-08-29T17:53:09","slug":"kazia-therapeutics-recruits-keto-patient-phase-ii-paxalisib-study-treatment-glioblastoma","status":"publish","type":"post","link":"https:\/\/smallcapscn.x5view.co\/?p=4727","title":{"rendered":"Kazia Therapeutics \u62db\u52df\u9996\u540d\u916e\u75c7\u60a3\u8005\u53c2\u52a0 paxalisib \u6cbb\u7597\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7684 II \u671f\u7814\u7a76"},"content":{"rendered":"

\u8fd1\u65e5\uff0c\u80bf\u7624\u5b66\u836f\u7269\u5f00\u53d1\u516c\u53f8Kazia Therapeutics (ASX: KZA)\u62db\u52df\u4e86\u5176\u9996\u4e2a\u60a3\u8005\u53c2\u4e0e\u4e00\u9879\u5b9e\u9a8c\u6027\u65b0\u836fpaxalisib\u7684II\u671f\u7814\u7a76\uff0c\u8be5\u836f\u7269\u7528\u4e8e\u6cbb\u7597\u65b0\u8bca\u65ad\u548c\u590d\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u3002<\/p>\n

\u8fd9\u9879\u4e3a\u671f\u4e24\u5e74\u7684\u7814\u7a76\u7531\u7ebd\u7ea6Weill Cornell Medical Centre\u53d1\u8d77\uff0c\u5c06\u5728\u4e24\u7ec4\u60a3\u8005\u4e2d\u8c03\u67e5paxalisib\u8054\u5408\u7cd6\u5c3f\u75c5\u836f\u7269\u4e8c\u7532\u53cc\u80cd(metaformin)\u548c\u751f\u916e\u996e\u98df\u7684\u7597\u6548\uff0c\u521d\u59cb\u961f\u5217\u540416\u540d\u60a3\u8005\u3002<\/p>\n

\u7b2c\u4e00\u7ec4\u5c06\u5305\u62ec\u65b0\u8bca\u65ad\u7684\u6076\u6027\u80f6\u8d28\u7624\u60a3\u8005\uff0c\u8fd9\u4e9b\u60a3\u8005\u6709\u672a\u7532\u57fa\u5316MGMT\u542f\u52a8\u5b50\u72b6\u6001\uff0c\u8fc7\u53bb\u5bf9\u76ee\u524d\u6807\u51c6\u7684\u6cbb\u7597\u836f\u7269temozolomide\u53cd\u5e94\u4e0d\u4f73\u3002<\/p>\n

\u7b2c\u4e8c\u7ec4\u5c06\u5305\u62ec\u63a5\u53d7\u6807\u51c6\u6cbb\u7597\u540e\u75c5\u60c5\u8fdb\u5c55\u7684\u590d\u53d1\u6027\u75be\u75c5\u60a3\u8005(\u65e0\u8bba\u5176MGMT\u542f\u52a8\u5b50\u7684\u7532\u57fa\u5316\u72b6\u6001\u5982\u4f55)\u3002<\/p>\n

\u5728\u6bcf\u4e00\u7ec4\u4e2d\uff0cpaxalisib\u8054\u5408\u4e8c\u7532\u53cc\u80cd\u548c\u751f\u916e\u996e\u98df\u5c06\u7531\u4e34\u5e8a\u8425\u517b\u5e08\u76d1\u7763\uff0c\u4ee5\u786e\u4fdd\u5176\u79d1\u5b66\u5408\u7406\uff0c\u5e76\u786e\u4fdd\u60a3\u8005\u4f9d\u4ece\u3002<\/p>\n

Kazia\u8bf4\uff0c\u5982\u679c\u67d0\u4e00\u7279\u5b9a\u7fa4\u4f53\u51fa\u73b0\u6d3b\u52a8\u4fe1\u53f7\uff0c\u8be5\u7fa4\u4f53\u5c06\u6269\u5927\u5230\u5927\u7ea630\u540d\u60a3\u8005\u3002<\/p>\n

\u9664\u4e86\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff0c\u8be5\u7814\u7a76\u8fd8\u5c06\u68c0\u6d4b\u4e00\u7cfb\u5217\u4ee3\u8c22\u3001\u836f\u6548\u5b66\u548c\u65b0\u578b\u653e\u5c04\u6210\u50cf\u751f\u7269\u6807\u5fd7\u7269\uff0c\u4e3a\u672a\u6765\u7684\u7814\u7a76\u548c\u4e34\u5e8a\u5b9e\u8df5\u63d0\u4f9b\u4fe1\u606f\u3002<\/p>\n

\u4f4e\u80f0\u5c9b\u7d20\u72b6\u6001<\/h2>\n

Lew Cantley\u6559\u6388\u53d1\u73b0\u4e86PI3K\u901a\u8def(\u4eba\u4f53\u6700\u91cd\u8981\u7684\u7ec6\u80de\u5185\u901a\u8def\u4e4b\u4e00\uff0c\u53ef\u88ab\u8ba4\u4e3a\u662f\u764c\u75c7\u7684\u4e3b\u8981\u8c03\u8282\u56e0\u5b50)\uff0c\u4ed6\u7684\u7814\u7a76\u8868\u660e\uff0c\u4f4e\u80f0\u5c9b\u7d20\u72b6\u6001\u53ef\u80fd\u4f1a\u589e\u5f3aPI3K\u6291\u5236\u5242(\u5982paxalisib)\u7684\u6d3b\u6027\u3002<\/p>\n

\u636e\u62a5\u9053\uff0c\u8bf1\u5bfc\u751f\u916e\u72b6\u6001\u2014\u2014\u8eab\u4f53\u7531\u8102\u80aa\u548c\u86cb\u767d\u8d28\u800c\u4e0d\u662f\u8461\u8404\u7cd6\u63d0\u4f9b\u80fd\u91cf\u2014\u2014\u662f\u964d\u4f4e\u80f0\u5c9b\u7d20\u6c34\u5e73\u7684\u6709\u6548\u65b9\u6cd5\u3002<\/p>\n

\u4e0e\u5065\u5eb7\u7ec6\u80de\u4e0d\u540c\uff0c\u5927\u591a\u6570\u80bf\u7624\u7ec6\u80de\u4ee3\u8c22\u916e\u7684\u80fd\u529b\u8f83\u5dee\uff0c\u5b83\u4eec\u4f9d\u8d56\u8461\u8404\u7cd6\u6765\u6ee1\u8db3\u80fd\u91cf\u9700\u6c42\u3002<\/p>\n

\u8bb8\u591a\u7814\u7a76\u4eba\u5458\u5df2\u7ecf\u8bd5\u9a8c\u4e86\u201c\u751f\u916e\u996e\u98df\u201d\u4f5c\u4e3a\u4e00\u79cd\u6f5c\u5728\u7684\u764c\u75c7\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n

\u5728Kazia\u7814\u7a76\u4e2d\uff0c\u589e\u52a0\u4e8c\u7532\u53cc\u80cd\u7684\u6cbb\u7597\u65e8\u5728\u8fdb\u4e00\u6b65\u964d\u4f4e\u60a3\u8005\u7684\u80f0\u5c9b\u7d20\u6c34\u5e73\u3002<\/p>\n

\u63a2\u7d22\u5173\u7cfb<\/h2>\n

\u8be5\u9879\u7814\u7a76\u7684\u9996\u5e2d\u7814\u7a76\u5458\u3001Weill Cornell\u7684Brain Tumour Centre\u7684\u521b\u59cb\u4e3b\u4efbHoward Fine\u535a\u58eb\u8bf4\uff0c\u8fd9\u9879\u7814\u7a76\u5c06\u63a2\u7d22paxalisib\u3001\u4e8c\u7532\u53cc\u80cd\u548c\u751f\u916e\u4e4b\u95f4\u7684\u5173\u7cfb\u3002<\/p>\n

\u4ed6\u8bf4:\u201c\u6211\u7684\u540c\u4e8b\u548c\u6211\u76f8\u4fe1\uff0c\u7ed9\u5904\u4e8e\u751f\u916e\u72b6\u6001\u7684\u60a3\u8005\u4f7f\u7528paxalisib\u53ef\u80fd\u4f1a\u663e\u8457\u63d0\u9ad8\u5176\u7597\u6548\uff0c\u6211\u4eec\u6709\u5e7f\u6cdb\u548c\u975e\u5e38\u4ee4\u4eba\u4fe1\u670d\u7684\u4e34\u5e8a\u524d\u6570\u636e\u652f\u6301\u8fd9\u4e00\u65b9\u6cd5\u3002\u201d<\/p>\n

\u201c\u5b83\u4e3a\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u5de8\u5927\u7684\u6f5c\u529b\uff0c\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u4ecd\u7136\u662f\u73b0\u4ee3\u533b\u5b66\u4e2d\u6700\u5177\u6311\u6218\u6027\u7684\u764c\u75c7\u4e4b\u4e00\u3002\u201d<\/p>\n

Fine\u535a\u58eb\u7684\u5b9e\u9a8c\u5ba4\u5df2\u7ecf\u8bc1\u660e\u80f0\u5c9b\u7d20\u53ef\u4ee5\u9006\u8f6cPI3K\u6291\u5236\u5242\u5728\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7ec6\u80de\u4e2d\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3002<\/p>\n

\u4ed6\u8bf4:\u201c\u7531\u4e8e\u8fd9\u4e9b\u539f\u56e0\uff0c\u5728\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u4e2d\u63a2\u7d22\u4e8c\u7532\u53cc\u80cd\u3001\u751f\u916e\u996e\u98df\u548cpaxalisib\u7684\u7ec4\u5408\u662f\u6709\u5408\u7406\u7684\u7406\u8bba\u57fa\u7840\u7684\u3002\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

\u8fd1\u65e5\uff0c\u80bf\u7624\u5b66\u836f\u7269\u5f00\u53d1\u516c\u53f8Kazia Therapeutics (ASX: KZA)\u62db\u52df\u4e86\u5176\u9996\u4e2a\u60a3\u8005\u53c2\u4e0e\u4e00\u9879\u5b9e\u9a8c\u6027\u65b0\u836fpaxalisib\u7684II\u671f\u7814\u7a76\uff0c\u8be5\u836f\u7269\u7528\u4e8e\u6cbb\u7597\u65b0\u8bca\u65ad\u548c\u590d\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u3002 \u8fd9\u9879\u4e3a\u671f\u4e24\u5e74\u7684\u7814\u7a76\u7531\u7ebd\u7ea6Weill Cornell Medical Centre\u53d1\u8d77\uff0c\u5c06\u5728\u4e24\u7ec4\u60a3\u8005\u4e2d\u8c03\u67e5paxalisib\u8054\u5408\u7cd6\u5c3f\u75c5\u836f\u7269\u4e8c\u7532\u53cc\u80cd(metaformin)\u548c\u751f\u916e\u996e\u98df\u7684\u7597\u6548\uff0c\u521d\u59cb\u961f\u5217\u540416\u540d\u60a3\u8005\u3002 \u7b2c\u4e00\u7ec4\u5c06\u5305\u62ec\u65b0\u8bca\u65ad\u7684\u6076\u6027\u80f6\u8d28\u7624\u60a3\u8005\uff0c\u8fd9\u4e9b\u60a3\u8005\u6709\u672a\u7532\u57fa\u5316MGMT\u542f\u52a8\u5b50\u72b6\u6001\uff0c\u8fc7\u53bb\u5bf9\u76ee\u524d\u6807\u51c6\u7684\u6cbb\u7597\u836f\u7269temozolomide\u53cd\u5e94\u4e0d\u4f73\u3002 \u7b2c\u4e8c\u7ec4\u5c06\u5305\u62ec\u63a5\u53d7\u6807\u51c6\u6cbb\u7597\u540e\u75c5\u60c5\u8fdb\u5c55\u7684\u590d\u53d1\u6027\u75be\u75c5\u60a3\u8005(\u65e0\u8bba\u5176MGMT\u542f\u52a8\u5b50\u7684\u7532\u57fa\u5316\u72b6\u6001\u5982\u4f55)\u3002 \u5728\u6bcf\u4e00\u7ec4\u4e2d\uff0cpaxalisib\u8054\u5408\u4e8c\u7532\u53cc\u80cd\u548c\u751f\u916e\u996e\u98df\u5c06\u7531\u4e34\u5e8a\u8425\u517b\u5e08\u76d1\u7763\uff0c\u4ee5\u786e\u4fdd\u5176\u79d1\u5b66\u5408\u7406\uff0c\u5e76\u786e\u4fdd\u60a3\u8005\u4f9d\u4ece\u3002 Kazia\u8bf4\uff0c\u5982\u679c\u67d0\u4e00\u7279\u5b9a\u7fa4\u4f53\u51fa\u73b0\u6d3b\u52a8\u4fe1\u53f7\uff0c\u8be5\u7fa4\u4f53\u5c06\u6269\u5927\u5230\u5927\u7ea630\u540d\u60a3\u8005\u3002 \u9664\u4e86\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff0c\u8be5\u7814\u7a76\u8fd8\u5c06\u68c0\u6d4b\u4e00\u7cfb\u5217\u4ee3\u8c22\u3001\u836f\u6548\u5b66\u548c\u65b0\u578b\u653e\u5c04\u6210\u50cf\u751f\u7269\u6807\u5fd7\u7269\uff0c\u4e3a\u672a\u6765\u7684\u7814\u7a76\u548c\u4e34\u5e8a\u5b9e\u8df5\u63d0\u4f9b\u4fe1\u606f\u3002 \u4f4e\u80f0\u5c9b\u7d20\u72b6\u6001 Lew Cantley\u6559\u6388\u53d1\u73b0\u4e86PI3K\u901a\u8def(\u4eba\u4f53\u6700\u91cd\u8981\u7684\u7ec6\u80de\u5185\u901a\u8def\u4e4b\u4e00\uff0c\u53ef\u88ab\u8ba4\u4e3a\u662f\u764c\u75c7\u7684\u4e3b\u8981\u8c03\u8282\u56e0\u5b50)\uff0c\u4ed6\u7684\u7814\u7a76\u8868\u660e\uff0c\u4f4e\u80f0\u5c9b\u7d20\u72b6\u6001\u53ef\u80fd\u4f1a\u589e\u5f3aPI3K\u6291\u5236\u5242(\u5982paxalisib)\u7684\u6d3b\u6027\u3002 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