{"id":4827,"date":"2022-03-21T04:15:53","date_gmt":"2022-03-21T04:15:53","guid":{"rendered":"\/\/smallcapscn.x5view.co\/?p=4827"},"modified":"2023-08-29T18:01:36","modified_gmt":"2023-08-29T18:01:36","slug":"argenica-therapeutics-publishes-scientific-paper-arg-007-clinical-trials","status":"publish","type":"post","link":"https:\/\/smallcapscn.x5view.co\/?p=4827","title":{"rendered":"Argenica Therapeutics\u5728\u4e34\u5e8a\u8bd5\u9a8c\u524d\u53d1\u8868\u4e86\u6709\u5173ARG-007\u7684\u79d1\u5b66\u8bba\u6587"},"content":{"rendered":"

\u751f\u7269\u6280\u672f\u516c\u53f8Argenica Therapeutics (ASX: AGN)\u5ba3\u5e03\uff0c\u5176\u9996\u5e2d\u79d1\u5b66\u5b98Bruno Meloni\u6559\u6388\u53d1\u8868\u4e86\u4e00\u7bc7\u5173\u4e8e\u8be5\u516c\u53f8\u9886\u5148\u7684\u795e\u7ecf\u4fdd\u62a4\u8d44\u4ea7ARG-007\u7684\u540c\u884c\u8bc4\u8bae\u8bba\u6587\u3002<\/p>\n

\u8fd9\u7bc7\u9898\u4e3a\u300aImpact of poly-arginine peptides R18D and R18 on alteplase and Tenecteplase thrombolysis in vitro, and neuroprotective stability to proteolysis\u300b(\u591a\u7cbe\u6c28\u9178\u591a\u80bdR18D\u548cR18\u5bf9\u963f\u66ff\u666e\u9176\u548c\u66ff\u5c3c\u666e\u9176\u4f53\u5916\u6eb6\u6813\u7684\u5f71\u54cd\uff0c\u4ee5\u53ca\u5bf9\u86cb\u767d\u6c34\u89e3\u7684\u795e\u7ecf\u4fdd\u62a4\u7a33\u5b9a\u6027)\u7684\u8bba\u6587\u73b0\u5728\u53d1\u8868\u5728\u300aJournal of Thrombosis and Thrombolysis\u300b\u4e0a\uff0c\u8bc1\u5b9e\u4e86R18D\u591a\u80bd(ARG-007)\u7684\u201c\u5353\u8d8a\u7684\u86cb\u767d\u6c34\u89e3\u7a33\u5b9a\u6027\u201d\u3002<\/p>\n

\u8fd9\u662f\u57fa\u4e8e\u8be5\u516c\u53f8\u53bb\u5e747\u6708\u5411ASX\u62a5\u544a\u7684\u4e00\u9879\u7814\u7a76\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u8868\u660e\uff0c\u5f53R18D (ARG-007)\u4e0e\u6eb6\u6813\u8bf1\u5bfc\u5242alteplase (tPA)\u548cTenecteplase (TNK)\u5171\u540c\u4f7f\u7528\u65f6\uff0c\u53ef\u4ee5\u964d\u89e3\u80bd\uff0c\u5728\u4e34\u5e8a\u8840\u6813\u6eb6\u89e3\u8fc7\u7a0b\u4e2d\u4f7f\u7528ARG-007\u4e0d\u4f1a\u964d\u89e3\uff0c\u4e5f\u4e0d\u4f1a\u5bf9ARG-007\u7684\u7597\u6548\u4ea7\u751f\u8d1f\u9762\u5f71\u54cd\u3002<\/p>\n

Argenica \u9996\u5e2d\u6267\u884c\u5b98Liz Dallimore\u535a\u58eb\u8bf4\uff0c\u540c\u884c\u8bc4\u8bae\u7684\u79d1\u5b66\u671f\u520a\u5bf9\u8fd9\u9879\u7814\u7a76\u7684\u8ba4\u53ef\u662f\u201c\u5bf9Meloni\u6559\u6388\u548c\u4ed6\u7684\u5408\u4f5c\u8005\u56e2\u961f\u6240\u91c7\u7528\u7684\u79d1\u5b66\u4e25\u8c28\u6027\u7684\u8bc1\u660e\u201d\u3002<\/p>\n

\u6b63\u5728\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c<\/h2>\n

Argenica \u4e13\u6ce8\u4e8e\u5f00\u53d1\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u4ee5\u51cf\u5c11\u4e2d\u98ce\u540e\u7684\u8111\u7ec4\u7ec7\u6b7b\u4ea1\u548c\u6539\u5584\u60a3\u8005\u7684\u9884\u540e\u3002<\/p>\n

\u5b83\u7684\u76ee\u7684\u662f\u8ba9\u6025\u6551\u4eba\u5458\u5bf9\u5176\u8fdb\u884c\u6cbb\u7597\uff0c\u4ee5\u4fdd\u62a4\u5927\u8111\u7ec4\u7ec7\u514d\u53d7\u4e2d\u98ce\u671f\u95f4\u7684\u635f\u4f24\uff0c\u5e76\u8fdb\u4e00\u6b65\u589e\u5f3a\u4e2d\u98ce\u53d1\u751f\u540e\u7684\u6062\u590d\u6f5c\u529b\u3002<\/p>\n

ARG-007\u5df2\u5728\u4e34\u5e8a\u524d\u4e2d\u98ce\u6a21\u578b\u4e2d\u8bc1\u660e\u5176\u7597\u6548\u6539\u5584\uff0c\u5728\u5f00\u59cb\u4eba\u7c7b\u4e00\u671f\u4e34\u5e8a\u8bd5\u9a8c\u524d\uff0c\u5176\u5b89\u5168\u6027\u548c\u6bd2\u6027\u6b63\u5904\u4e8e\u9a8c\u8bc1\u8fc7\u7a0b\u4e2d\u3002<\/p>\n

\u4e0a\u4e2a\u6708\uff0c\u968f\u7740\u6700\u7ec8\u826f\u597d\u5b9e\u9a8c\u5ba4\u89c4\u8303(GLP)\u57fa\u56e0\u6bd2\u6027\u7814\u7a76\u7684\u5b8c\u6210\uff0cArgenica \u5411\u4e34\u5e8a\u8bd5\u9a8c\u53c8\u8fc8\u8fdb\u4e86\u4e00\u6b65\u3002\u636e\u8be5\u516c\u53f8\u79f0\uff0c\u4f53\u5916\u7814\u7a76\u7684\u6570\u636e\u663e\u793a\uff0cARG-007\u201c\u4e0d\u592a\u53ef\u80fd\u5bf9\u60a3\u8005\u6784\u6210\u9057\u4f20\u6216\u81f4\u764c\u98ce\u9669\u201d\u3002<\/p>\n

\u6b64\u5916\uff0cARG-007\u7684\u57fa\u56e0\u6bd2\u6027\u7814\u7a76\u9700\u8981\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\u7684\u76d1\u7ba1\u6279\u51c6\u3002<\/p>\n

\u4e2d\u98ce\u5f15\u8d77\u7684\u8111\u635f\u4f24<\/h2>\n

\u6839\u636eArgenica \u6700\u8fd1\u7684\u6295\u8d44\u8005\u62a5\u544a\uff0c\u5168\u4e16\u754c\u6bcf\u5e74\u67091500\u4e07\u4eba\u60a3\u4e2d\u98ce\uff0c\u53ea\u670910%\u7684\u4eba\u80fd\u5b8c\u5168\u5eb7\u590d\u3002<\/p>\n

\u8fd9\u79cd\u4f4e\u6062\u590d\u7387\u4e0e\u8111\u7ec6\u80de\u635f\u4f24\u6709\u5173\uff0c\u56e0\u4e3a\u8840\u6db2\u6d41\u91cf\u7684\u51cf\u5c11\u6bcf\u5206\u949f\u4f1a\u5bfc\u81f4190\u4e07\u4e2a\u8111\u7ec6\u80de\u6b7b\u4ea1\uff0c\u7814\u7a76\u8868\u660e\uff0c\u4e2d\u98ce\u6cbb\u7597\u7684\u5ef6\u8fdf\u6bcf\u5c0f\u65f6\u4f1a\u4f7f\u5927\u8111\u8870\u80013.6\u5c81\u3002<\/p>\n

\u6839\u636eArgenica \u7684\u8bf4\u6cd5\uff0c\u76ee\u524d\u8fd8\u6ca1\u6709\u666e\u904d\u53ef\u7528\u7684\u836f\u7269\u6765\u4fdd\u62a4\u4e2d\u98ce\u540e\u7684\u8111\u7ec6\u80de\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u751f\u7269\u6280\u672f\u516c\u53f8Argenica Therapeutics (ASX: AGN)\u5ba3\u5e03\uff0c\u5176\u9996\u5e2d\u79d1\u5b66\u5b98Bruno Meloni\u6559\u6388\u53d1\u8868\u4e86\u4e00\u7bc7\u5173\u4e8e\u8be5\u516c\u53f8\u9886\u5148\u7684\u795e\u7ecf\u4fdd\u62a4\u8d44\u4ea7ARG-007\u7684\u540c\u884c\u8bc4\u8bae\u8bba\u6587\u3002 \u8fd9\u7bc7\u9898\u4e3a\u300aImpact of poly-arginine peptides R18D and R18 on alteplase and Tenecteplase thrombolysis in vitro, and neuroprotective stability to proteolysis\u300b(\u591a\u7cbe\u6c28\u9178\u591a\u80bdR18D\u548cR18\u5bf9\u963f\u66ff\u666e\u9176\u548c\u66ff\u5c3c\u666e\u9176\u4f53\u5916\u6eb6\u6813\u7684\u5f71\u54cd\uff0c\u4ee5\u53ca\u5bf9\u86cb\u767d\u6c34\u89e3\u7684\u795e\u7ecf\u4fdd\u62a4\u7a33\u5b9a\u6027)\u7684\u8bba\u6587\u73b0\u5728\u53d1\u8868\u5728\u300aJournal of Thrombosis and Thrombolysis\u300b\u4e0a\uff0c\u8bc1\u5b9e\u4e86R18D\u591a\u80bd(ARG-007)\u7684\u201c\u5353\u8d8a\u7684\u86cb\u767d\u6c34\u89e3\u7a33\u5b9a\u6027\u201d\u3002 \u8fd9\u662f\u57fa\u4e8e\u8be5\u516c\u53f8\u53bb\u5e747\u6708\u5411ASX\u62a5\u544a\u7684\u4e00\u9879\u7814\u7a76\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u8868\u660e\uff0c\u5f53R18D (ARG-007)\u4e0e\u6eb6\u6813\u8bf1\u5bfc\u5242alteplase (tPA)\u548cTenecteplase (TNK)\u5171\u540c\u4f7f\u7528\u65f6\uff0c\u53ef\u4ee5\u964d\u89e3\u80bd\uff0c\u5728\u4e34\u5e8a\u8840\u6813\u6eb6\u89e3\u8fc7\u7a0b\u4e2d\u4f7f\u7528ARG-007\u4e0d\u4f1a\u964d\u89e3\uff0c\u4e5f\u4e0d\u4f1a\u5bf9ARG-007\u7684\u7597\u6548\u4ea7\u751f\u8d1f\u9762\u5f71\u54cd\u3002 Argenica \u9996\u5e2d\u6267\u884c\u5b98Liz Dallimore\u535a\u58eb\u8bf4\uff0c\u540c\u884c\u8bc4\u8bae\u7684\u79d1\u5b66\u671f\u520a\u5bf9\u8fd9\u9879\u7814\u7a76\u7684\u8ba4\u53ef\u662f\u201c\u5bf9Meloni\u6559\u6388\u548c\u4ed6\u7684\u5408\u4f5c\u8005\u56e2\u961f\u6240\u91c7\u7528\u7684\u79d1\u5b66\u4e25\u8c28\u6027\u7684\u8bc1\u660e\u201d\u3002 \u6b63\u5728\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c Argenica \u4e13\u6ce8\u4e8e\u5f00\u53d1\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u4ee5\u51cf\u5c11\u4e2d\u98ce\u540e\u7684\u8111\u7ec4\u7ec7\u6b7b\u4ea1\u548c\u6539\u5584\u60a3\u8005\u7684\u9884\u540e\u3002 \u5b83\u7684\u76ee\u7684\u662f\u8ba9\u6025\u6551\u4eba\u5458\u5bf9\u5176\u8fdb\u884c\u6cbb\u7597\uff0c\u4ee5\u4fdd\u62a4\u5927\u8111\u7ec4\u7ec7\u514d\u53d7\u4e2d\u98ce\u671f\u95f4\u7684\u635f\u4f24\uff0c\u5e76\u8fdb\u4e00\u6b65\u589e\u5f3a\u4e2d\u98ce\u53d1\u751f\u540e\u7684\u6062\u590d\u6f5c\u529b\u3002 ARG-007\u5df2\u5728\u4e34\u5e8a\u524d\u4e2d\u98ce\u6a21\u578b\u4e2d\u8bc1\u660e\u5176\u7597\u6548\u6539\u5584\uff0c\u5728\u5f00\u59cb\u4eba\u7c7b\u4e00\u671f\u4e34\u5e8a\u8bd5\u9a8c\u524d\uff0c\u5176\u5b89\u5168\u6027\u548c\u6bd2\u6027\u6b63\u5904\u4e8e\u9a8c\u8bc1\u8fc7\u7a0b\u4e2d\u3002 \u4e0a\u4e2a\u6708\uff0c\u968f\u7740\u6700\u7ec8\u826f\u597d\u5b9e\u9a8c\u5ba4\u89c4\u8303(GLP)\u57fa\u56e0\u6bd2\u6027\u7814\u7a76\u7684\u5b8c\u6210\uff0cArgenica \u5411\u4e34\u5e8a\u8bd5\u9a8c\u53c8\u8fc8\u8fdb\u4e86\u4e00\u6b65\u3002\u636e\u8be5\u516c\u53f8\u79f0\uff0c\u4f53\u5916\u7814\u7a76\u7684\u6570\u636e\u663e\u793a\uff0cARG-007\u201c\u4e0d\u592a\u53ef\u80fd\u5bf9\u60a3\u8005\u6784\u6210\u9057\u4f20\u6216\u81f4\u764c\u98ce\u9669\u201d\u3002 \u6b64\u5916\uff0cARG-007\u7684\u57fa\u56e0\u6bd2\u6027\u7814\u7a76\u9700\u8981\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\u7684\u76d1\u7ba1\u6279\u51c6\u3002 \u4e2d\u98ce\u5f15\u8d77\u7684\u8111\u635f\u4f24 \u6839\u636eArgenica \u6700\u8fd1\u7684\u6295\u8d44\u8005\u62a5\u544a\uff0c\u5168\u4e16\u754c\u6bcf\u5e74\u67091500\u4e07\u4eba\u60a3\u4e2d\u98ce\uff0c\u53ea\u670910%\u7684\u4eba\u80fd\u5b8c\u5168\u5eb7\u590d\u3002 \u8fd9\u79cd\u4f4e\u6062\u590d\u7387\u4e0e\u8111\u7ec6\u80de\u635f\u4f24\u6709\u5173\uff0c\u56e0\u4e3a\u8840\u6db2\u6d41\u91cf\u7684\u51cf\u5c11\u6bcf\u5206\u949f\u4f1a\u5bfc\u81f4190\u4e07\u4e2a\u8111\u7ec6\u80de\u6b7b\u4ea1\uff0c\u7814\u7a76\u8868\u660e\uff0c\u4e2d\u98ce\u6cbb\u7597\u7684\u5ef6\u8fdf\u6bcf\u5c0f\u65f6\u4f1a\u4f7f\u5927\u8111\u8870\u80013.6\u5c81\u3002 \u6839\u636eArgenica \u7684\u8bf4\u6cd5\uff0c\u76ee\u524d\u8fd8\u6ca1\u6709\u666e\u904d\u53ef\u7528\u7684\u836f\u7269\u6765\u4fdd\u62a4\u4e2d\u98ce\u540e\u7684\u8111\u7ec6\u80de\u3002<\/p>\n","protected":false},"author":5,"featured_media":18604,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[888],"yoast_head":"\nArgenica Therapeutics\u5728\u4e34\u5e8a\u8bd5\u9a8c\u524d\u53d1\u8868\u4e86\u6709\u5173ARG-007\u7684\u79d1\u5b66\u8bba\u6587<\/title>\n<meta name=\"description\" content=\"\u751f\u7269\u6280\u672f\u516c\u53f8Argenica Therapeutics 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