{"id":4955,"date":"2022-04-08T01:19:14","date_gmt":"2022-04-08T01:19:14","guid":{"rendered":"\/\/smallcapscn.x5view.co\/?p=4955"},"modified":"2023-08-29T17:53:39","modified_gmt":"2023-08-29T17:53:39","slug":"kazia-therapeutics-paxalisib-rare-childhood-brain-cancer-pre-clinical-research","status":"publish","type":"post","link":"https:\/\/smallcapscn.x5view.co\/?p=4955","title":{"rendered":"Kazia Therapeutics \u7684 paxalisib \u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u663e\u793a\u51fa\u5bf9\u7f55\u89c1\u7684\u513f\u7ae5\u8111\u764c\u7684\u6d3b\u6027"},"content":{"rendered":"

Kazia Therapeutics (ASX: KZA) \u62ab\u9732\u4e86\u4e34\u5e8a\u524d\u6570\u636e\uff0c\u8868\u660e\u5176\u836f\u7269 paxalisib \u5728\u4e24\u79cd\u5f62\u5f0f\u7684\u513f\u7ae5\u8111\u764c\u4e2d\u8868\u73b0\u51fa\u6d3b\u6027\uff0c\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u975e\u5e38\u9ad8\u3002<\/p>\n

\u8be5\u516c\u53f8\u5728\u65b0\u5965\u5c14\u826f\u4e3e\u884c\u7684American Association for Cancer Research \u00a0(AACR) \u5e74\u4f1a\u4e0a\u516c\u5e03\u4e86\u4e34\u5e8a\u524d\u6570\u636e\u3002<\/p>\n

\u6839\u636e Kazia \u7684\u8bf4\u6cd5\uff0c\u8fd9\u662f\u9996\u6b21\u5728\u8fd9\u79cd\u88ab\u79f0\u4e3a\u975e\u5178\u578b\u7578\u80ce\u7624\/\u6a2a\u7eb9\u808c\u7624\u7684\u8111\u764c\u4e2d\u63a2\u7d22 paxalisib \u7684\u6570\u636e\u3002<\/p>\n

\u8fd9\u4e9b\u662f\u4ece\u5927\u8111\u548c\u810a\u9ad3\u5f00\u59cb\u7684\u7f55\u89c1\u4e14\u5feb\u901f\u751f\u957f\u7684\u80bf\u7624\u3002\u80bf\u7624\u901a\u5e38\u51fa\u73b0\u5728\u4e09\u5c81\u53ca\u4ee5\u4e0b\u7684\u513f\u7ae5\u8eab\u4e0a\u3002<\/p>\n

\u5728Baltimore\u7684Johns Hopkins University\u5de5\u4f5c\u7684\u79d1\u5b66\u5bb6\u5728\u4ed6\u4eec\u7684\u62a5\u544a\u6458\u8981\u4e2d\u5c06 paxalisib \u63cf\u8ff0\u4e3a\u6cbb\u7597\u975e\u5178\u578b\u7578\u80ce\u7624\/\u6a2a\u7eb9\u808c\u7624\u7684\u201c\u9aa8\u5e72\u7597\u6cd5\u201d\u3002<\/p>\n

\u79d1\u5b66\u5bb6\u4eec\u5728\u52a9\u7406\u6559\u6388\u6770\u5f17\u91cc\u00b7\u9c81\u672c\u65af\u7684\u5b9e\u9a8c\u5ba4\u91cc\u5de5\u4f5c\u3002<\/p>\n

\u4fb5\u88ad\u6027\u513f\u7ae5\u8111\u764c<\/h2>\n

\u6765\u81eaJohns Hopkins University\u53e6\u4e00\u4e2a\u56e2\u961f\u7684\u7b2c\u4e09\u4efd\u6458\u8981\u663e\u793a\u4e86 paxalisib \u4e0e\u5176\u4ed6\u764c\u75c7\u7597\u6cd5\u4e4b\u95f4\u7684\u201c\u5f3a\u5927\u534f\u540c\u4f5c\u7528\u201d\u3002\u8fd9\u5728\u5f25\u6f2b\u6027\u5185\u5728\u8111\u6865\u80f6\u8d28\u7624 (DIPG) \u6a21\u578b\u4e2d\u5f97\u5230\u8bc1\u5b9e\u3002<\/p>\n

DIPG \u662f\u53e6\u4e00\u79cd\u5177\u6709\u9ad8\u5ea6\u4fb5\u88ad\u6027\u4e14\u96be\u4ee5\u6cbb\u7597\u7684\u513f\u7ae5\u8111\u80bf\u7624\u3002<\/p>\n

Kazia \u6307\u51fa\uff0cpaxalisib \u5148\u524d\u5df2\u5728 DIPG \u4e2d\u663e\u793a\u51fa\u6d3b\u6027\uff0c\u65e2\u53ef\u4ee5\u4f5c\u4e3a\u5355\u4e00\u7597\u6cd5\uff0c\u4e5f\u53ef\u4ee5\u4e0e\u5176\u4ed6\u764c\u75c7\u7597\u6cd5\u8054\u5408\u4f7f\u7528\u3002<\/p>\n

\u9996\u5e2d\u6267\u884c\u5b98James Garner\u535a\u58eb\u8868\u793a\uff0c\u8fd9\u4e9b\u6570\u636e\u201c\u975e\u5e38\u6709\u5e0c\u671b\u201d\u3002<\/p>\n

\u201cPaxalisib \u5df2\u7ecf\u662f DIPG \u548c\u5f25\u6f2b\u6027\u4e2d\u7ebf\u795e\u7ecf\u80f6\u8d28\u7624\u6b63\u5728\u8fdb\u884c\u7684 II \u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e3b\u9898\uff0c\u8fd9\u4e00\u65b0\u6570\u636e\u8868\u660e\u8be5\u836f\u7269\u5728\u513f\u7ae5\u8111\u764c\u4e2d\u7684\u6f5c\u5728\u66f4\u5e7f\u6cdb\u5e94\u7528\u3002\u201d<\/p>\n

Paxalisib<\/h2>\n

Paxalisib \u662f Kazia \u7684\u4e3b\u8981\u836f\u7269\uff0c\u5df2\u88ab\u5f00\u53d1\u4e3a PI2K\/Akt\/mTOR \u901a\u8def\u7684\u8111\u6e17\u900f\u6291\u5236\u5242\u3002<\/p>\n

\u8be5\u836f\u7269\u65e8\u5728\u6cbb\u7597\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff0c\u8fd9\u662f\u6210\u4eba\u539f\u53d1\u6027\u8111\u764c\u4e2d\u6700\u5177\u4fb5\u88ad\u6027\u7684\u5f62\u5f0f\u3002<\/p>\n

\u76ee\u524d\uff0cKazia \u6709 8 \u9879\u989d\u5916\u7684\u7814\u7a76\u8bc4\u4f30 paxalisib \u6cbb\u7597\u5404\u79cd\u5f62\u5f0f\u7684\u8111\u764c\u3002<\/p>\n

Paxalisib \u62e5\u6709\u7f8e\u56fd FDA \u5b64\u513f\u836f\u6307\u5b9a\u548c\u7528\u4e8e\u6cbb\u7597\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7684\u5feb\u901f\u901a\u9053\u6307\u5b9a\u3002\u5b83\u8fd8\u5177\u6709 DIPG \u7684\u7f55\u89c1\u513f\u79d1\u75be\u75c5\u6307\u5b9a\u548c\u5b64\u513f\u836f\u6307\u5b9a\u3002<\/p>\n

EVT801<\/h2>\n

\u5728\u65b0\u5965\u5c14\u826f\u4e3e\u884c\u7684 AACR \u4f1a\u8bae\u4e0a\uff0cKazia \u8fd8\u4ecb\u7ecd\u4e86\u5176\u65b0\u836f EVT801\uff0c\u8be5\u836f\u5177\u6709\u6cbb\u7597\u591a\u79cd\u764c\u75c7\u7684\u6f5c\u529b\u3002<\/p>\n

\u8be5\u836f\u7269\u662f VEGFR3 \u7684\u6291\u5236\u5242\uff0cVEGFR3 \u662f\u53c2\u4e0e\u5728\u751f\u957f\u7684\u80bf\u7624\u5468\u56f4\u5f62\u6210\u65b0\u6dcb\u5df4\u7ba1\u7684\u53d7\u4f53\u3002<\/p>\n

\u4e34\u5e8a\u524d\u6570\u636e\u8868\u660e EVT801 \u53ef\u6291\u5236\u65b0\u80bf\u7624\u7684\u751f\u957f\u548c\u6269\u6563\uff0c\u540c\u65f6\u8fd8\u53ef\u4e0e\u5176\u4ed6\u514d\u75ab\u80bf\u7624\u7597\u6cd5\u534f\u540c\u5de5\u4f5c\u3002<\/p>\n

Garner \u535a\u58eb\u8868\u793a\uff0cEVT801 \u662f\u4e00\u79cd\u201c\u5177\u6709\u5de8\u5927\u6f5c\u529b\u7684\u4ee4\u4eba\u5174\u594b\u7684\u65b0\u5019\u9009\u836f\u7269\u201d\u3002<\/p>\n

Kazia \u6b63\u5728\u6cd5\u56fd\u7684\u4e24\u4e2a\u5730\u70b9\u62db\u52df\u60a3\u8005\u8fdb\u884c EVT801 \u7684 I \u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

Kazia Therapeutics (ASX: KZA) \u62ab\u9732\u4e86\u4e34\u5e8a\u524d\u6570\u636e\uff0c\u8868\u660e\u5176\u836f\u7269 paxalisib \u5728\u4e24\u79cd\u5f62\u5f0f\u7684\u513f\u7ae5\u8111\u764c\u4e2d\u8868\u73b0\u51fa\u6d3b\u6027\uff0c\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u975e\u5e38\u9ad8\u3002 \u8be5\u516c\u53f8\u5728\u65b0\u5965\u5c14\u826f\u4e3e\u884c\u7684American Association for Cancer Research \u00a0(AACR) \u5e74\u4f1a\u4e0a\u516c\u5e03\u4e86\u4e34\u5e8a\u524d\u6570\u636e\u3002 \u6839\u636e Kazia \u7684\u8bf4\u6cd5\uff0c\u8fd9\u662f\u9996\u6b21\u5728\u8fd9\u79cd\u88ab\u79f0\u4e3a\u975e\u5178\u578b\u7578\u80ce\u7624\/\u6a2a\u7eb9\u808c\u7624\u7684\u8111\u764c\u4e2d\u63a2\u7d22 paxalisib \u7684\u6570\u636e\u3002 \u8fd9\u4e9b\u662f\u4ece\u5927\u8111\u548c\u810a\u9ad3\u5f00\u59cb\u7684\u7f55\u89c1\u4e14\u5feb\u901f\u751f\u957f\u7684\u80bf\u7624\u3002\u80bf\u7624\u901a\u5e38\u51fa\u73b0\u5728\u4e09\u5c81\u53ca\u4ee5\u4e0b\u7684\u513f\u7ae5\u8eab\u4e0a\u3002 \u5728Baltimore\u7684Johns Hopkins University\u5de5\u4f5c\u7684\u79d1\u5b66\u5bb6\u5728\u4ed6\u4eec\u7684\u62a5\u544a\u6458\u8981\u4e2d\u5c06 paxalisib \u63cf\u8ff0\u4e3a\u6cbb\u7597\u975e\u5178\u578b\u7578\u80ce\u7624\/\u6a2a\u7eb9\u808c\u7624\u7684\u201c\u9aa8\u5e72\u7597\u6cd5\u201d\u3002 \u79d1\u5b66\u5bb6\u4eec\u5728\u52a9\u7406\u6559\u6388\u6770\u5f17\u91cc\u00b7\u9c81\u672c\u65af\u7684\u5b9e\u9a8c\u5ba4\u91cc\u5de5\u4f5c\u3002 \u4fb5\u88ad\u6027\u513f\u7ae5\u8111\u764c \u6765\u81eaJohns Hopkins University\u53e6\u4e00\u4e2a\u56e2\u961f\u7684\u7b2c\u4e09\u4efd\u6458\u8981\u663e\u793a\u4e86 paxalisib \u4e0e\u5176\u4ed6\u764c\u75c7\u7597\u6cd5\u4e4b\u95f4\u7684\u201c\u5f3a\u5927\u534f\u540c\u4f5c\u7528\u201d\u3002\u8fd9\u5728\u5f25\u6f2b\u6027\u5185\u5728\u8111\u6865\u80f6\u8d28\u7624 (DIPG) \u6a21\u578b\u4e2d\u5f97\u5230\u8bc1\u5b9e\u3002 DIPG \u662f\u53e6\u4e00\u79cd\u5177\u6709\u9ad8\u5ea6\u4fb5\u88ad\u6027\u4e14\u96be\u4ee5\u6cbb\u7597\u7684\u513f\u7ae5\u8111\u80bf\u7624\u3002 Kazia \u6307\u51fa\uff0cpaxalisib \u5148\u524d\u5df2\u5728 DIPG \u4e2d\u663e\u793a\u51fa\u6d3b\u6027\uff0c\u65e2\u53ef\u4ee5\u4f5c\u4e3a\u5355\u4e00\u7597\u6cd5\uff0c\u4e5f\u53ef\u4ee5\u4e0e\u5176\u4ed6\u764c\u75c7\u7597\u6cd5\u8054\u5408\u4f7f\u7528\u3002 \u9996\u5e2d\u6267\u884c\u5b98James Garner\u535a\u58eb\u8868\u793a\uff0c\u8fd9\u4e9b\u6570\u636e\u201c\u975e\u5e38\u6709\u5e0c\u671b\u201d\u3002 \u201cPaxalisib \u5df2\u7ecf\u662f DIPG \u548c\u5f25\u6f2b\u6027\u4e2d\u7ebf\u795e\u7ecf\u80f6\u8d28\u7624\u6b63\u5728\u8fdb\u884c\u7684 II \u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e3b\u9898\uff0c\u8fd9\u4e00\u65b0\u6570\u636e\u8868\u660e\u8be5\u836f\u7269\u5728\u513f\u7ae5\u8111\u764c\u4e2d\u7684\u6f5c\u5728\u66f4\u5e7f\u6cdb\u5e94\u7528\u3002\u201d Paxalisib Paxalisib \u662f Kazia \u7684\u4e3b\u8981\u836f\u7269\uff0c\u5df2\u88ab\u5f00\u53d1\u4e3a PI2K\/Akt\/mTOR… Continue reading Kazia Therapeutics \u7684 paxalisib \u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u663e\u793a\u51fa\u5bf9\u7f55\u89c1\u7684\u513f\u7ae5\u8111\u764c\u7684\u6d3b\u6027<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":18964,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[498],"yoast_head":"\nKazia Therapeutics \u7684 paxalisib \u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u663e\u793a\u51fa\u5bf9\u7f55\u89c1\u7684\u513f\u7ae5\u8111\u764c\u7684\u6d3b\u6027<\/title>\n<meta name=\"description\" content=\"Kazia Therapeutics (ASX: KZA) \u62ab\u9732\u4e86\u4e34\u5e8a\u524d\u6570\u636e\uff0c\u8868\u660e\u5176\u836f\u7269 paxalisib \u5728\u4e24\u79cd\u5f62\u5f0f\u7684\u513f\u7ae5\u8111\u764c\u4e2d\u8868\u73b0\u51fa\u6d3b\u6027\uff0c\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u975e\u5e38\u9ad8\u3002\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kazia Therapeutics \u7684 paxalisib \u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u663e\u793a\u51fa\u5bf9\u7f55\u89c1\u7684\u513f\u7ae5\u8111\u764c\u7684\u6d3b\u6027\" \/>\n<meta property=\"og:description\" content=\"Kazia Therapeutics (ASX: KZA) \u62ab\u9732\u4e86\u4e34\u5e8a\u524d\u6570\u636e\uff0c\u8868\u660e\u5176\u836f\u7269 paxalisib \u5728\u4e24\u79cd\u5f62\u5f0f\u7684\u513f\u7ae5\u8111\u764c\u4e2d\u8868\u73b0\u51fa\u6d3b\u6027\uff0c\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u975e\u5e38\u9ad8\u3002\" \/>\n<meta property=\"og:url\" content=\"https:\/\/smallcapscn.x5view.co\/kazia-therapeutics-paxalisib-rare-childhood-brain-cancer-pre-clinical-research\/\" \/>\n<meta property=\"og:site_name\" content=\"smallcapsCN\" \/>\n<meta property=\"article:published_time\" content=\"2022-04-08T01:19:14+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-08-29T17:53:39+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/smallcapscn.x5view.co\/wp-content\/uploads\/2023\/08\/Kazia-Therapeutics-ASX-KZA-paxalisib-childhood-brain-cancer-paediatric-tumour.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"640\" \/>\n\t<meta property=\"og:image:height\" content=\"400\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Lorna Nicholas\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Lorna Nicholas\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/smallcapscn.x5view.co\/kazia-therapeutics-paxalisib-rare-childhood-brain-cancer-pre-clinical-research\/\",\"url\":\"https:\/\/smallcapscn.x5view.co\/kazia-therapeutics-paxalisib-rare-childhood-brain-cancer-pre-clinical-research\/\",\"name\":\"Kazia Therapeutics \u7684 paxalisib 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