{"id":5239,"date":"2022-06-01T01:44:11","date_gmt":"2022-06-01T01:44:11","guid":{"rendered":"\/\/smallcapscn.x5view.co\/?p=5239"},"modified":"2023-08-29T17:54:17","modified_gmt":"2023-08-29T17:54:17","slug":"kazia-therapeutics-adds-recruitment-sites-paxalisib-global-glioblastoma-study","status":"publish","type":"post","link":"https:\/\/smallcapscn.x5view.co\/?p=5239","title":{"rendered":"Kazia Therapeutics \u4e3a\u5168\u7403\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7814\u7a76\u7684 paxalisib \u90e8\u95e8\u589e\u52a0\u4e86\u62db\u52df\u7ad9\u70b9"},"content":{"rendered":"

\u4ee5\u80bf\u7624\u5b66\u4e3a\u91cd\u70b9\u7684\u836f\u7269\u5f00\u53d1\u516c\u53f8 Kazia Therapeutics (ASX: KZA) \u5df2\u786e\u8ba4\u591a\u836f\u7269\u5e73\u53f0\u7814\u7a76 GBM AGILE \u5df2\u5f00\u59cb\u62db\u52df\u5176\u5728\u6b27\u6d32\u7684 paxalisib \u90e8\u95e8\u3002<\/p>\n

GBM AGILE \u662f\u4e00\u9879\u7531\u5b66\u672f\u4e3b\u5bfc\u7684\u5168\u7403\u6027\u7814\u7a76\uff0c\u65e8\u5728\u786e\u5b9a\u6709\u5e0c\u671b\u7684\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u65b0\u7597\u6cd5\uff0c\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u662f\u6210\u4eba\u539f\u53d1\u6027\u8111\u764c\u4e2d\u6700\u5e38\u89c1\u548c\u6700\u5177\u4fb5\u88ad\u6027\u7684\u5f62\u5f0f\u3002<\/p>\n

\u8be5\u7814\u7a76\u7531\u5168\u7403\u9002\u5e94\u6027\u7814\u7a76\u8054\u76df (GCAR) \u8d5e\u52a9\uff0c\u6d89\u53ca\u4e09\u79cd\u5019\u9009\u836f\u7269\u2014\u2014\u62dc\u8033\u7684 regorafenib\u3001Kazia \u7684 paxalisib \u548c Kintara Therapeutics \u7684 VAL-083\u3002<\/p>\n

Biohaven Pharmaceuticals troriluzole \u836f\u7269\u548c Vigeo Therapeutics \u7684 VG1021 \u5c06\u4e8e\u4eca\u5e74\u665a\u4e9b\u65f6\u5019\u8fdb\u5165\u7814\u7a76\u3002<\/p>\n

\u5b66\u4e60\u5730\u70b9<\/h2>\n

Kazia \u5ba3\u5e03University Hospital of Zurich\u5c06\u52a0\u5165\u7f8e\u56fd\u548c\u52a0\u62ff\u5927\u7684 40 \u591a\u4e2a\u7814\u7a76\u5730\u70b9\uff0c\u8fd9\u4e9b\u7814\u7a76\u5730\u70b9\u76ee\u524d\u6b63\u5728\u62db\u52df\u60a3\u8005\u52a0\u5165 paxalisib \u90e8\u95e8\u3002<\/p>\n

\u8fd9\u4ee3\u8868\u4e86 paxalisib \u9996\u6b21\u6210\u4e3a\u745e\u58eb\u4e34\u5e8a\u8bd5\u9a8c\u6d3b\u52a8\u7684\u4e3b\u9898\u3002<\/p>\n

\u9884\u8ba1\u4e0d\u4e45\u7684\u5c06\u6765\u8fd8\u4f1a\u5728\u745e\u58eb\u548c\u5176\u4ed6\u51e0\u4e2a\u6b27\u6d32\u56fd\u5bb6\u5f00\u8bbe\u66f4\u591a\u7ad9\u70b9\u3002<\/p>\n

\u8be5\u5927\u5b66\u795e\u7ecf\u75c5\u5b66\u7cfb\u4e3b\u4efbMichael Weller\u535a\u58eb\u8868\u793a\uff0c\u5c06\u8bd5\u9a8c\u6269\u5c55\u5230\u6b27\u6d32\u662f\u4e00\u4e2a\u79ef\u6781\u7684\u53d1\u5c55\u3002<\/p>\n

\u201c\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u8feb\u5207\u9700\u8981\u65b0\u7684\u6cbb\u7597\u9009\u62e9\uff0cGBM AGILE \u65e8\u5728\u4ee5\u6700\u6709\u6548\u7684\u65b9\u5f0f\u8bc4\u4f30\u65b0\u7597\u6cd5\uff0c\u201d\u4ed6\u8bf4\u3002<\/p>\n

\u201c\u6211\u4eec\u671f\u5f85\u4e3a\u8fd9\u9879\u7814\u7a76\u505a\u51fa\u91cd\u5927\u8d21\u732e\uff0c\u5e76\u5728\u9002\u5f53\u7684\u65f6\u5019\u770b\u5230\u7ed3\u679c\u3002\u201d<\/p>\n

\u8111\u6e17\u900f\u6291\u5236\u5242<\/h2>\n

Paxalisib \u662f PI3K \/ Akt \/ mTOR \u901a\u8def\u7684\u8111\u6e17\u900f\u6291\u5236\u5242\uff0c\u6b63\u5728\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u3002<\/p>\n

\u8be5\u836f\u7269\u4e8e 2016 \u5e74\u5e95\u4eceGenentech\u83b7\u5f97\u8bb8\u53ef\uff0c\u4e8e\u53bb\u5e74 1 \u6708\u5f00\u59cb\u62db\u52df GBM AGILE\u3002<\/p>\n

Paxalisib \u4e8e 2018 \u5e74\u521d\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\u6388\u4e88\u7684\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u5b64\u513f\u836f\u8d44\u683c\uff0c\u5e76\u4e8e 2020 \u5e74\u5e74\u4e2d\u83b7\u5f97\u5feb\u901f\u901a\u9053\u8d44\u683c<\/a>\u3002<\/p>\n

\u5b83\u8fd8\u4e8e 2020 \u5e74\u88ab\u7f8e\u56fd FDA \u6388\u4e88\u7f55\u89c1\u7684\u513f\u79d1\u75be\u75c5\u8ba4\u5b9a\u548c\u5f25\u6f2b\u6027<\/a>\u5185\u5728\u8111\u6865\u80f6\u8d28\u7624\uff08\u53e6\u4e00\u79cd\u9ad8\u4fb5\u88ad\u6027\u80bf\u7624\uff09\u7684\u5b64\u513f\u8ba4\u5b9a\u3002<\/p>\n

Paxalisib\u62db\u52df<\/h2>\n

GBM AGILE \u7684 paxalisib \u90e8\u95e8\u5c06\u62db\u52df\u5177\u6709\u672a\u7532\u57fa\u5316 MGMT \u542f\u52a8\u5b50\uff08\u4e00\u79cd\u9057\u4f20\u6807\u8bb0\uff0c\u8868\u793a\u5bf9\u73b0\u6709 FDA \u6279\u51c6\u7684\u62a4\u7406\u836f\u7269\u66ff\u83ab\u5511\u80fa\u6807\u51c6\u51e0\u4e4e\u5b8c\u5168\u8010\u836f\uff09\u7684\u65b0\u8bca\u65ad\u60a3\u8005\u548c\u5c3d\u7ba1\u63a5\u53d7\u4e86\u66ff\u83ab\u5511\u80fa\u6cbb\u7597\u4f46\u4ecd\u6709\u8fdb\u5c55\u7684\u590d\u53d1\u60a3\u8005\u3002<\/p>\n

\u62db\u52df\u5230 paxalisib \u7ec4\u7684\u60a3\u8005\u5c06\u4e0e\u5171\u4eab\u5bf9\u7167\u7ec4\u8fdb\u884c\u6bd4\u8f83\u3002<\/p>\n

\u62db\u751f\u65f6\u95f4\u9884\u8ba1\u572830\u4e2a\u6708\u81f336\u4e2a\u6708\u4e4b\u95f4\uff0c\u9884\u8ba1\u660e\u5e74\u5e74\u5e95\u51fa\u6700\u7ec8\u6570\u636e\u3002<\/p>\n

GBM AGILE \u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u603b\u751f\u5b58\u671f\uff0c\u8fd9\u4e5f\u88ab\u8ba4\u4e3a\u662f\u8bc4\u4f30\u65b0\u764c\u75c7\u7597\u6cd5\u7684\u91d1\u6807\u51c6\uff0c\u4e5f\u662f\u5305\u62ec\u7f8e\u56fd FDA \u5728\u5185\u7684\u76d1\u7ba1\u673a\u6784\u7684\u9996\u9009\u6279\u51c6\u7ec8\u70b9\u3002<\/p>\n

Kazia \u9884\u8ba1 GBM AGILE \u5c06\u6210\u4e3a\u5728\u5305\u62ec\u6b27\u76df\u5728\u5185\u7684\u4e3b\u8981\u5e02\u573a\u8fdb\u884c\u6ce8\u518c\u7684\u5173\u952e\u7814\u7a76\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u4ee5\u80bf\u7624\u5b66\u4e3a\u91cd\u70b9\u7684\u836f\u7269\u5f00\u53d1\u516c\u53f8 Kazia Therapeutics (ASX: KZA) \u5df2\u786e\u8ba4\u591a\u836f\u7269\u5e73\u53f0\u7814\u7a76 GBM AGILE \u5df2\u5f00\u59cb\u62db\u52df\u5176\u5728\u6b27\u6d32\u7684 paxalisib \u90e8\u95e8\u3002 GBM AGILE \u662f\u4e00\u9879\u7531\u5b66\u672f\u4e3b\u5bfc\u7684\u5168\u7403\u6027\u7814\u7a76\uff0c\u65e8\u5728\u786e\u5b9a\u6709\u5e0c\u671b\u7684\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u65b0\u7597\u6cd5\uff0c\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u662f\u6210\u4eba\u539f\u53d1\u6027\u8111\u764c\u4e2d\u6700\u5e38\u89c1\u548c\u6700\u5177\u4fb5\u88ad\u6027\u7684\u5f62\u5f0f\u3002 \u8be5\u7814\u7a76\u7531\u5168\u7403\u9002\u5e94\u6027\u7814\u7a76\u8054\u76df (GCAR) \u8d5e\u52a9\uff0c\u6d89\u53ca\u4e09\u79cd\u5019\u9009\u836f\u7269\u2014\u2014\u62dc\u8033\u7684 regorafenib\u3001Kazia \u7684 paxalisib \u548c Kintara Therapeutics \u7684 VAL-083\u3002 Biohaven Pharmaceuticals troriluzole \u836f\u7269\u548c Vigeo Therapeutics \u7684 VG1021 \u5c06\u4e8e\u4eca\u5e74\u665a\u4e9b\u65f6\u5019\u8fdb\u5165\u7814\u7a76\u3002 \u5b66\u4e60\u5730\u70b9 Kazia \u5ba3\u5e03University Hospital of Zurich\u5c06\u52a0\u5165\u7f8e\u56fd\u548c\u52a0\u62ff\u5927\u7684 40 \u591a\u4e2a\u7814\u7a76\u5730\u70b9\uff0c\u8fd9\u4e9b\u7814\u7a76\u5730\u70b9\u76ee\u524d\u6b63\u5728\u62db\u52df\u60a3\u8005\u52a0\u5165 paxalisib \u90e8\u95e8\u3002 \u8fd9\u4ee3\u8868\u4e86 paxalisib \u9996\u6b21\u6210\u4e3a\u745e\u58eb\u4e34\u5e8a\u8bd5\u9a8c\u6d3b\u52a8\u7684\u4e3b\u9898\u3002 \u9884\u8ba1\u4e0d\u4e45\u7684\u5c06\u6765\u8fd8\u4f1a\u5728\u745e\u58eb\u548c\u5176\u4ed6\u51e0\u4e2a\u6b27\u6d32\u56fd\u5bb6\u5f00\u8bbe\u66f4\u591a\u7ad9\u70b9\u3002 \u8be5\u5927\u5b66\u795e\u7ecf\u75c5\u5b66\u7cfb\u4e3b\u4efbMichael Weller\u535a\u58eb\u8868\u793a\uff0c\u5c06\u8bd5\u9a8c\u6269\u5c55\u5230\u6b27\u6d32\u662f\u4e00\u4e2a\u79ef\u6781\u7684\u53d1\u5c55\u3002 \u201c\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u8feb\u5207\u9700\u8981\u65b0\u7684\u6cbb\u7597\u9009\u62e9\uff0cGBM AGILE \u65e8\u5728\u4ee5\u6700\u6709\u6548\u7684\u65b9\u5f0f\u8bc4\u4f30\u65b0\u7597\u6cd5\uff0c\u201d\u4ed6\u8bf4\u3002 \u201c\u6211\u4eec\u671f\u5f85\u4e3a\u8fd9\u9879\u7814\u7a76\u505a\u51fa\u91cd\u5927\u8d21\u732e\uff0c\u5e76\u5728\u9002\u5f53\u7684\u65f6\u5019\u770b\u5230\u7ed3\u679c\u3002\u201d \u8111\u6e17\u900f\u6291\u5236\u5242… Continue reading Kazia Therapeutics \u4e3a\u5168\u7403\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7814\u7a76\u7684 paxalisib \u90e8\u95e8\u589e\u52a0\u4e86\u62db\u52df\u7ad9\u70b9<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":17291,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[498],"yoast_head":"\nKazia Therapeutics \u4e3a\u5168\u7403\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7814\u7a76\u7684 paxalisib \u90e8\u95e8\u589e\u52a0\u4e86\u62db\u52df\u7ad9\u70b9<\/title>\n<meta name=\"description\" content=\"\u4ee5\u80bf\u7624\u5b66\u4e3a\u91cd\u70b9\u7684\u836f\u7269\u5f00\u53d1\u516c\u53f8 Kazia Therapeutics (ASX: KZA) \u5df2\u786e\u8ba4\u591a\u836f\u7269\u5e73\u53f0\u7814\u7a76 GBM AGILE \u5df2\u5f00\u59cb\u62db\u52df\u5176\u5728\u6b27\u6d32\u7684 paxalisib \u90e8\u95e8\u3002\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kazia Therapeutics \u4e3a\u5168\u7403\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7814\u7a76\u7684 paxalisib \u90e8\u95e8\u589e\u52a0\u4e86\u62db\u52df\u7ad9\u70b9\" \/>\n<meta property=\"og:description\" content=\"\u4ee5\u80bf\u7624\u5b66\u4e3a\u91cd\u70b9\u7684\u836f\u7269\u5f00\u53d1\u516c\u53f8 Kazia Therapeutics (ASX: KZA) \u5df2\u786e\u8ba4\u591a\u836f\u7269\u5e73\u53f0\u7814\u7a76 GBM AGILE \u5df2\u5f00\u59cb\u62db\u52df\u5176\u5728\u6b27\u6d32\u7684 paxalisib \u90e8\u95e8\u3002\" \/>\n<meta property=\"og:url\" content=\"https:\/\/smallcapscn.x5view.co\/kazia-therapeutics-adds-recruitment-sites-paxalisib-global-glioblastoma-study\/\" \/>\n<meta property=\"og:site_name\" content=\"smallcapsCN\" \/>\n<meta property=\"article:published_time\" content=\"2022-06-01T01:44:11+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-08-29T17:54:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/smallcapscn.x5view.co\/wp-content\/uploads\/2023\/08\/Kazia-Therapeutics-ASX-KZA-recruitment-sites-paxalisib-global-glioblastoma-study-GBM-AGILE.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"640\" \/>\n\t<meta property=\"og:image:height\" content=\"400\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Imelda Cotton\" \/>\n<meta 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