{"id":5277,"date":"2022-06-08T02:13:41","date_gmt":"2022-06-08T02:13:41","guid":{"rendered":"\/\/smallcapscn.x5view.co\/?p=5277"},"modified":"2023-08-29T18:01:34","modified_gmt":"2023-08-29T18:01:34","slug":"kazia-therapeutics-expands-paxalisib-study-include-secondary-brain-tumours-breast-cancer","status":"publish","type":"post","link":"https:\/\/smallcapscn.x5view.co\/?p=5277","title":{"rendered":"Kazia Therapeutics \u6269\u5927\u4e86 paxalisib \u7814\u7a76\u4ee5\u5305\u62ec\u4e73\u817a\u764c\u7ee7\u53d1\u6027\u8111\u80bf\u7624"},"content":{"rendered":"

\u4ee5\u80bf\u7624\u5b66\u4e3a\u91cd\u70b9\u7684\u836f\u7269\u5f00\u53d1\u5546 Kazia Therapeutics (ASX: KZA) \u6b63\u5728\u6269\u5927\u5176\u836f\u7269 paxalisib \u5728\u8111\u8f6c\u79fb\u60a3\u8005\u4e2d\u7684\u4e8c\u671f\u7814\u7a76\uff0c\u4ee5\u5305\u62ec\u90a3\u4e9b\u4ece\u4e73\u817a\u764c\u5f00\u59cb\u7684\u60a3\u8005\u3002<\/p>\n

\u8fd9\u9879\u7531\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u7f51\u7edcAlliance for Clinical Trials in Oncology\u9886\u5bfc\u7684\u57fa\u56e0\u7ec4\u6307\u5bfc\u7814\u7a76\u6b63\u5728\u8bc4\u4f30\u8111\u8f6c\u79fb\u60a3\u8005\u7684\u591a\u79cd\u6cbb\u7597\u65b9\u6cd5\uff0c\u5f53\u764c\u75c7\u4ece\u8eab\u4f53\u5176\u4ed6\u90e8\u4f4d\u6269\u6563\u5e76\u5728\u5927\u8111\u4e2d\u53d1\u5c55\u51fa\u7ee7\u53d1\u6027\u80bf\u7624\u65f6\uff0c\u5c31\u4f1a\u53d1\u751f\u8fd9\u79cd\u60c5\u51b5\u3002<\/p>\n

Kazia \u4eca\u5929\u8bc1\u5b9e\uff0c\u5728\u5b8c\u6210\u9884\u5148\u6307\u5b9a\u7684\u4e2d\u671f\u5206\u6790\u540e\uff0c\u8be5\u7814\u7a76\u7684 paxalisib \u5206\u652f\u6b63\u5728\u63a8\u8fdb\u5230\u4e73\u817a\u764c\u7684\u6269\u5f20\u9636\u6bb5\u3002<\/p>\n

\u8be5\u7814\u7a76\u7684\u9996\u5e2d\u7814\u7a76\u5458 Priscilla Brastianos \u535a\u58eb\u8bf4\uff0c\u5bf9\u4e8e\u8111\u8f6c\u79fb\u7624\uff0c\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\u4ecd\u7136\u96be\u4ee5\u6349\u6478\u3002<\/p>\n

\u201c\u8fd9\u9879\u7814\u7a76\u65e8\u5728\u4e3a\u8111\u8f6c\u79fb\u60a3\u8005\u786e\u5b9a\u6f5c\u5728\u7684\u65b0\u7597\u6cd5\uff0c\u4f7f\u7528\u9886\u5148\u7684\u57fa\u56e0\u7ec4\u6280\u672f\u4e3a\u60a3\u8005\u5206\u914d\u6700\u5408\u9002\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u201d<\/p>\n

\u201c\u6211\u4eec\u671f\u5f85\u7740\u7ee7\u7eed\u5728\u8fd9\u4e00\u91cd\u8981\u75be\u75c5\u9886\u57df\u63a2\u7d22 paxalisib\uff0c\u201dBrastianos \u535a\u58eb\u8865\u5145\u9053\u3002<\/p>\n

Alliance\u7814\u7a76<\/h2>\n

Alliance\u7684\u7814\u7a76\u6b63\u5728\u62db\u52df\u56e0\u4e73\u817a\u764c\u3001\u80ba\u764c\u548c\u5176\u4ed6\u539f\u53d1\u6027\u80bf\u7624\u800c\u5bfc\u81f4\u8111\u8f6c\u79fb\u7684\u60a3\u8005\u3002\u6839\u636e\u80bf\u7624\u7684\u9057\u4f20\u7279\u5f81\uff0c\u60a3\u8005\u88ab\u5206\u914d\u63a5\u53d7 abemaciclib (Lilly)\u3001entrectinib (Genentech) \u6216 paxalisib (Kazia)\u3002<\/p>\n

\u5bf9\u4e8e\u6bcf\u79cd\u836f\u7269-\u80bf\u7624\u7ec4\u5408\uff08\u4f8b\u5982\uff0c\u80ba\u764c\u8111\u8f6c\u79fb\u60a3\u8005\u4e2d\u7684 paxalisib\uff09\uff0c\u8be5\u7814\u7a76\u8bbe\u60f3\u6bcf\u4e2a\u4e9a\u7ec4\uff08\u4f8b\u5982\u4e73\u817a\u3001\u80ba\u3001\u5176\u4ed6\uff09\u7684\u521d\u59cb\u9636\u6bb5\u4e3a 10 \u540d\u60a3\u8005\u3002<\/p>\n

\u5982\u679c\u5728\u6bcf\u4e2a\u4e9a\u7ec4 10 \u540d\u60a3\u8005\u7684\u4e2d\u671f\u5206\u6790\u4e2d\u6ee1\u8db3\u9884\u5148\u6307\u5b9a\u7684\u53cd\u5e94\u6807\u51c6\uff0c\u8be5\u7814\u7a76\u5c06\u6269\u5927\u8be5\u836f\u7269-\u80bf\u7624\u7ec4\u5408\u4ee5\u62db\u52df\u53e6\u5916 11 \u540d\u60a3\u8005\uff0c\u4ee5\u5bfb\u6c42\u660e\u786e\u7684\u7597\u6548\u6570\u636e\u3002<\/p>\n

\u5728\u4eca\u5929\u7684\u516c\u544a\u4e2d\uff0cKazia \u8bc1\u5b9e paxalisib \u90e8\u95e8\u5df2\u5b8c\u5168\u62db\u52df\u4e73\u817a\u764c\u961f\u5217\u8fdb\u884c\u521d\u6b65\u9884\u5148\u6307\u5b9a\u7684\u4e2d\u671f\u5206\u6790\uff0c\u5e76\u5df2\u8fbe\u5230\u8fc7\u6e21\u5230\u7814\u7a76\u6269\u5c55\u9636\u6bb5\u7684\u95e8\u69db\u3002<\/p>\n

Paxalisib \u5728\u80ba\u764c\u548c\u5176\u4ed6\u80bf\u7624\u4e2d\u7684\u7814\u7a76\u7684\u521d\u59cb\u9636\u6bb5\u6b63\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n

\u8111\u8f6c\u79fb\u7624<\/h2>\n

\u6839\u636e Kazia \u7684\u8bf4\u6cd5\uff0c\u9ad8\u8fbe 30% \u7684\u8f6c\u79fb\u6027\u764c\u75c7\u60a3\u8005\u4f1a\u5728\u5927\u8111\u4e2d\u53d1\u5c55\u51fa\u7ee7\u53d1\u6027\u80bf\u7624\uff08\u8f6c\u79fb\u7076\uff09\u3002\u4ec5\u5728\u7f8e\u56fd\uff0c\u6bcf\u5e74\u5c31\u4f30\u8ba1\u6709 200,000 \u4f8b\u65b0\u7684\u8111\u8f6c\u79fb\u75c5\u4f8b\u3002<\/p>\n

\u6cbb\u7597\u9009\u62e9\u4ecd\u7136\u6709\u9650\uff0c\u8111\u8f6c\u79fb\u60a3\u8005\u7684\u5e73\u5747\u751f\u5b58\u671f\u4ece 3 \u4e2a\u6708\u5230 27 \u4e2a\u6708\u4e0d\u7b49\uff0c\u8fd9\u53d6\u51b3\u4e8e\u5305\u62ec\u539f\u59cb\u80bf\u7624\u4f4d\u7f6e\u5728\u5185\u7684\u56e0\u7d20\u3002<\/p>\n

\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u4e8c\u671f\u7814\u7a76\u7684\u9633\u6027\u6570\u636e<\/h2>\n

\u4e0a\u5468\uff0cKazia \u5728\u4f0a\u5229\u8bfa\u4f0a\u5dde\u829d\u52a0\u54e5\u4e3e\u884c\u7684American Society for Clinical Oncology (ASCO) \u5e74\u4f1a\u4e0a\u516c\u5e03\u4e86 paxalisib \u5728\u65b0\u8bca\u65ad\u7684\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u4e2d\u7684\u4e8c\u671f\u7814\u7a76<\/a>\u7684\u79ef\u6781\u6700\u7ec8\u6570\u636e\u3002<\/p>\n

\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u662f\u6210\u4eba\u4e2d\u6700\u5e38\u89c1\u548c\u6700\u5177\u4fb5\u88ad\u6027\u7684\u539f\u53d1\u6027\u8111\u764c\u3002<\/p>\n

Kazia \u9996\u5e2d\u6267\u884c\u5b98 James Garner \u535a\u58eb\u8868\u793a\uff0c\u65b0\u6570\u636e\u63d0\u4f9b\u4e86\u66f4\u5b8c\u6574\u7684\u8bd5\u9a8c\u753b\u9762\uff0c\u5e76\u5305\u62ec\u4e00\u4e9b\u4fe1\u606f\u4e30\u5bcc\u7684\u654f\u611f\u6027\u5206\u6790\u3002<\/p>\n

\u201c\u5728\u6392\u9664\u4e0d\u53ef\u8bc4\u4f30\u60a3\u8005\u7684\u6539\u826f\u610f\u5411\u6cbb\u7597\uff08mITT\uff09\u4eba\u7fa4\u4e2d\uff0c\u751f\u5b58\u671f\u4ece 15.7 \u4e2a\u6708\u63d0\u9ad8\u5230 15.9 \u4e2a\u6708\u3002\u4f7f\u7528\u66f4\u7cbe\u786e\u7684 mRANO \u6807\u51c6\uff0cPFS \u4ece 8.4 \u4e2a\u6708\u63d0\u9ad8\u5230 8.6 \u4e2a\u6708\u3002\u201d<\/p>\n

\u201c\u8fd9\u4e9b\u5206\u6790\u7684\u65b9\u5411\u6027\u4f7f\u6211\u4eec\u5bf9\u89c2\u5bdf\u5230\u7684\u529f\u6548\u4fe1\u53f7\u66f4\u6709\u4fe1\u5fc3\uff0c\u5e76\u4e14\u5bf9\u672a\u6765\u7684\u53d1\u5c55\u4f3c\u4e4e\u4ee4\u4eba\u9f13\u821e\uff0c\u201d\u4ed6\u8865\u5145\u9053\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u4ee5\u80bf\u7624\u5b66\u4e3a\u91cd\u70b9\u7684\u836f\u7269\u5f00\u53d1\u5546 Kazia Therapeutics (ASX: KZA) \u6b63\u5728\u6269\u5927\u5176\u836f\u7269 paxalisib \u5728\u8111\u8f6c\u79fb\u60a3\u8005\u4e2d\u7684\u4e8c\u671f\u7814\u7a76\uff0c\u4ee5\u5305\u62ec\u90a3\u4e9b\u4ece\u4e73\u817a\u764c\u5f00\u59cb\u7684\u60a3\u8005\u3002 \u8fd9\u9879\u7531\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u7f51\u7edcAlliance for Clinical Trials in Oncology\u9886\u5bfc\u7684\u57fa\u56e0\u7ec4\u6307\u5bfc\u7814\u7a76\u6b63\u5728\u8bc4\u4f30\u8111\u8f6c\u79fb\u60a3\u8005\u7684\u591a\u79cd\u6cbb\u7597\u65b9\u6cd5\uff0c\u5f53\u764c\u75c7\u4ece\u8eab\u4f53\u5176\u4ed6\u90e8\u4f4d\u6269\u6563\u5e76\u5728\u5927\u8111\u4e2d\u53d1\u5c55\u51fa\u7ee7\u53d1\u6027\u80bf\u7624\u65f6\uff0c\u5c31\u4f1a\u53d1\u751f\u8fd9\u79cd\u60c5\u51b5\u3002 Kazia \u4eca\u5929\u8bc1\u5b9e\uff0c\u5728\u5b8c\u6210\u9884\u5148\u6307\u5b9a\u7684\u4e2d\u671f\u5206\u6790\u540e\uff0c\u8be5\u7814\u7a76\u7684 paxalisib \u5206\u652f\u6b63\u5728\u63a8\u8fdb\u5230\u4e73\u817a\u764c\u7684\u6269\u5f20\u9636\u6bb5\u3002 \u8be5\u7814\u7a76\u7684\u9996\u5e2d\u7814\u7a76\u5458 Priscilla Brastianos \u535a\u58eb\u8bf4\uff0c\u5bf9\u4e8e\u8111\u8f6c\u79fb\u7624\uff0c\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\u4ecd\u7136\u96be\u4ee5\u6349\u6478\u3002 \u201c\u8fd9\u9879\u7814\u7a76\u65e8\u5728\u4e3a\u8111\u8f6c\u79fb\u60a3\u8005\u786e\u5b9a\u6f5c\u5728\u7684\u65b0\u7597\u6cd5\uff0c\u4f7f\u7528\u9886\u5148\u7684\u57fa\u56e0\u7ec4\u6280\u672f\u4e3a\u60a3\u8005\u5206\u914d\u6700\u5408\u9002\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u201d \u201c\u6211\u4eec\u671f\u5f85\u7740\u7ee7\u7eed\u5728\u8fd9\u4e00\u91cd\u8981\u75be\u75c5\u9886\u57df\u63a2\u7d22 paxalisib\uff0c\u201dBrastianos \u535a\u58eb\u8865\u5145\u9053\u3002 Alliance\u7814\u7a76 Alliance\u7684\u7814\u7a76\u6b63\u5728\u62db\u52df\u56e0\u4e73\u817a\u764c\u3001\u80ba\u764c\u548c\u5176\u4ed6\u539f\u53d1\u6027\u80bf\u7624\u800c\u5bfc\u81f4\u8111\u8f6c\u79fb\u7684\u60a3\u8005\u3002\u6839\u636e\u80bf\u7624\u7684\u9057\u4f20\u7279\u5f81\uff0c\u60a3\u8005\u88ab\u5206\u914d\u63a5\u53d7 abemaciclib (Lilly)\u3001entrectinib (Genentech) \u6216 paxalisib (Kazia)\u3002 \u5bf9\u4e8e\u6bcf\u79cd\u836f\u7269-\u80bf\u7624\u7ec4\u5408\uff08\u4f8b\u5982\uff0c\u80ba\u764c\u8111\u8f6c\u79fb\u60a3\u8005\u4e2d\u7684 paxalisib\uff09\uff0c\u8be5\u7814\u7a76\u8bbe\u60f3\u6bcf\u4e2a\u4e9a\u7ec4\uff08\u4f8b\u5982\u4e73\u817a\u3001\u80ba\u3001\u5176\u4ed6\uff09\u7684\u521d\u59cb\u9636\u6bb5\u4e3a 10 \u540d\u60a3\u8005\u3002 \u5982\u679c\u5728\u6bcf\u4e2a\u4e9a\u7ec4 10 \u540d\u60a3\u8005\u7684\u4e2d\u671f\u5206\u6790\u4e2d\u6ee1\u8db3\u9884\u5148\u6307\u5b9a\u7684\u53cd\u5e94\u6807\u51c6\uff0c\u8be5\u7814\u7a76\u5c06\u6269\u5927\u8be5\u836f\u7269-\u80bf\u7624\u7ec4\u5408\u4ee5\u62db\u52df\u53e6\u5916 11 \u540d\u60a3\u8005\uff0c\u4ee5\u5bfb\u6c42\u660e\u786e\u7684\u7597\u6548\u6570\u636e\u3002 \u5728\u4eca\u5929\u7684\u516c\u544a\u4e2d\uff0cKazia \u8bc1\u5b9e paxalisib \u90e8\u95e8\u5df2\u5b8c\u5168\u62db\u52df\u4e73\u817a\u764c\u961f\u5217\u8fdb\u884c\u521d\u6b65\u9884\u5148\u6307\u5b9a\u7684\u4e2d\u671f\u5206\u6790\uff0c\u5e76\u5df2\u8fbe\u5230\u8fc7\u6e21\u5230\u7814\u7a76\u6269\u5c55\u9636\u6bb5\u7684\u95e8\u69db\u3002 Paxalisib \u5728\u80ba\u764c\u548c\u5176\u4ed6\u80bf\u7624\u4e2d\u7684\u7814\u7a76\u7684\u521d\u59cb\u9636\u6bb5\u6b63\u5728\u8fdb\u884c\u4e2d\u3002 \u8111\u8f6c\u79fb\u7624 \u6839\u636e Kazia \u7684\u8bf4\u6cd5\uff0c\u9ad8\u8fbe 30% \u7684\u8f6c\u79fb\u6027\u764c\u75c7\u60a3\u8005\u4f1a\u5728\u5927\u8111\u4e2d\u53d1\u5c55\u51fa\u7ee7\u53d1\u6027\u80bf\u7624\uff08\u8f6c\u79fb\u7076\uff09\u3002\u4ec5\u5728\u7f8e\u56fd\uff0c\u6bcf\u5e74\u5c31\u4f30\u8ba1\u6709… Continue reading Kazia Therapeutics \u6269\u5927\u4e86 paxalisib \u7814\u7a76\u4ee5\u5305\u62ec\u4e73\u817a\u764c\u7ee7\u53d1\u6027\u8111\u80bf\u7624<\/span><\/a><\/p>\n","protected":false},"author":5,"featured_media":17673,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[498],"yoast_head":"\nKazia Therapeutics \u6269\u5927\u4e86 paxalisib \u7814\u7a76\u4ee5\u5305\u62ec\u4e73\u817a\u764c\u7ee7\u53d1\u6027\u8111\u80bf\u7624<\/title>\n<meta name=\"description\" content=\"\u4ee5\u80bf\u7624\u5b66\u4e3a\u91cd\u70b9\u7684\u836f\u7269\u5f00\u53d1\u5546 Kazia Therapeutics (ASX: KZA) \u6b63\u5728\u6269\u5927\u5176\u836f\u7269 paxalisib \u5728\u8111\u8f6c\u79fb\u60a3\u8005\u4e2d\u7684\u4e8c\u671f\u7814\u7a76\uff0c\u4ee5\u5305\u62ec\u90a3\u4e9b\u4ece\u4e73\u817a\u764c\u5f00\u59cb\u7684\u60a3\u8005\u3002\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kazia Therapeutics \u6269\u5927\u4e86 paxalisib \u7814\u7a76\u4ee5\u5305\u62ec\u4e73\u817a\u764c\u7ee7\u53d1\u6027\u8111\u80bf\u7624\" \/>\n<meta property=\"og:description\" content=\"\u4ee5\u80bf\u7624\u5b66\u4e3a\u91cd\u70b9\u7684\u836f\u7269\u5f00\u53d1\u5546 Kazia Therapeutics (ASX: KZA) \u6b63\u5728\u6269\u5927\u5176\u836f\u7269 paxalisib \u5728\u8111\u8f6c\u79fb\u60a3\u8005\u4e2d\u7684\u4e8c\u671f\u7814\u7a76\uff0c\u4ee5\u5305\u62ec\u90a3\u4e9b\u4ece\u4e73\u817a\u764c\u5f00\u59cb\u7684\u60a3\u8005\u3002\" \/>\n<meta property=\"og:url\" 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