{"id":5303,"date":"2022-06-14T05:09:41","date_gmt":"2022-06-14T05:09:41","guid":{"rendered":"\/\/smallcapscn.x5view.co\/?p=5303"},"modified":"2023-08-29T17:54:26","modified_gmt":"2023-08-29T17:54:26","slug":"kazia-therapeutics-presents-positive-data-paxalisib-childhood-brain-cancers","status":"publish","type":"post","link":"https:\/\/smallcapscn.x5view.co\/?p=5303","title":{"rendered":"Kazia Therapeutics \u63d0\u4f9b\u4e86\u5173\u4e8e paxalisib \u5728\u513f\u7ae5\u8111\u764c\u4e2d\u7684\u201c\u79ef\u6781\u6570\u636e\u201d"},"content":{"rendered":"

\u5173\u4e8e Kazia Therapeutics (ASX: KZA) \u7684\u4e3b\u8981\u836f\u7269 paxalisib \u5728\u4e24\u79cd\u5f62\u5f0f\u7684\u513f\u7ae5\u8111\u764c\u4e2d\u7684\u6d3b\u6027\uff0c\u6b63\u5728\u5448\u73b0\u201c\u79ef\u6781\u6570\u636e\u201d\u3002<\/p>\n

\u8be5\u516c\u53f8\u672c\u5468\u5728\u5fb7\u56fd\u4e3e\u884c\u7684\u7b2c 20 \u5c4a\u5c0f\u513f\u795e\u7ecf\u80bf\u7624\u5b66\u56fd\u9645\u7814\u8ba8\u4f1a (International Symposium on Pediatric Neuro-Oncology\uff1bISPNO) \u4e0a\u901a\u8fc7\u4e24\u6b21\u6f14\u8bb2\u5c55\u793a\u4e86\u8fd9\u4e9b\u6570\u636e\u3002<\/p>\n

Johns Hopkins University\u7684 Jeffrey Rubens \u535a\u58eb\u8c08\u5230\u4e86 paxalisib \u4e0e\u7b2c\u4e8c\u79cd\u836f\u7269\u5728\u975e\u5178\u578b\u7578\u80ce\u7624\uff08teratoid\uff09\/\u6a2a\u7eb9\u808c\u7624\uff08rhabdoid\uff09\u52a8\u7269\u6a21\u578b\u4e2d\u7684\u6d3b\u6027\u3002<\/p>\n

\u7b2c\u4e8c\u4e2a\u6f14\u8bb2\u6765\u81ea\u6fb3\u5927\u5229\u4e9a\u7ebd\u5361\u65af\u5c14\u5927\u5b66Hunter Medical Research Institute\u7684\u526f\u6559\u6388 Matt Dun\u3002<\/p>\n

Dun\u535a\u58eb\u7684\u6f14\u8bb2\u6db5\u76d6\u4e86\u4e0e 10 \u4e2a\u56fd\u9645\u5b9e\u9a8c\u5ba4\u548c\u9886\u5148\u7684\u513f\u79d1\u4e2d\u5fc3\u5408\u4f5c\u5f00\u5c55\u7684\u5de5\u4f5c\u3002<\/p>\n

\u8fd9\u9879\u5de5\u4f5c\u6d89\u53ca paxalisib \u4e0e ONC201 \u7684\u7ec4\u5408\uff0cONC201 \u662f Chimerix \u5236\u9020\u7684\u7528\u4e8e\u6cbb\u7597\u5f25\u6f2b\u6027\u5185\u5728\u8111\u6865\u80f6\u8d28\u7624 (DIPG) \u7684\u7814\u7a76\u6027\u7597\u6cd5\u3002<\/p>\n

\u80bf\u7624\u201c\u663e\u7740\u51cf\u5c11\u201d<\/h2>\n

\u6839\u636e Kazia \u7684\u8bf4\u6cd5\uff0c\u5f25\u6f2b\u6027\u4e2d\u7ebf\u795e\u7ecf\u80f6\u8d28\u7624 (DMG) \u662f\u4e00\u7ec4\u513f\u7ae5\u8111\u764c\uff0c\u5176\u4e2d\u5305\u62ec DIPG\uff0c\u5b83\u88ab\u5f52\u7c7b\u4e3a\u9ad8\u5ea6\u4fb5\u88ad\u6027\u4e14\u96be\u4ee5\u6cbb\u7597\u3002<\/p>\n

\u6ca1\u6709\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u7684 DMG \u836f\u7269\u6cbb\u7597\uff0cDMG \u5360\u513f\u7ae5\u6240\u6709\u8111\u80bf\u7624\u7684 15%\u3002<\/p>\n

\u6b64\u5916\uff0c\u4ece\u8bca\u65ad\u5f00\u59cb\uff0c\u9884\u671f\u5bff\u547d\u5728 9 \u5230 11 \u4e2a\u6708\u4e4b\u95f4\u3002<\/p>\n

\u867d\u7136 ONC201 \u5df2\u5728 DIPG \u4e2d\u663e\u793a\u51fa\u7597\u6548\uff0c\u4f46 Kazia \u6307\u51fa\u60a3\u8005\u4f1a\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u5bf9\u8be5\u836f\u7269\u4ea7\u751f\u8010\u836f\u6027\u3002<\/p>\n

\u4e24\u540d\u63a5\u53d7 ONC201 \u548c paxalisib \u8054\u5408\u6cbb\u7597\u7684\u60a3\u8005\u8868\u73b0\u51fa\u201c\u80bf\u7624\u4f53\u79ef\u663e\u7740\u51cf\u5c0f\uff0c\u75be\u75c5\u75c7\u72b6\u5b8c\u5168\u6d88\u9000\u2014\u2014\u5ef6\u957f\u4e86\u603b\u4f53\u751f\u5b58\u671f\u201d\u3002<\/p>\n

\u5728 DIPG \u7684\u4e24\u4e2a\u52a8\u7269\u6a21\u578b\u4e2d\uff0cpaxalisib \u548c ONC201\u201c\u534f\u540c\u5ef6\u957f\u751f\u5b58\u671f\u201d\u4ece 73 \u5929\u5230 100 \u5929\u548c\u4ece 36 \u5929\u5230 43 \u5929\u3002<\/p>\n

\u8fd9\u9879\u7814\u7a76\u4fc3\u4f7f\u8be5\u836f\u7269\u7ec4\u5408\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e8e\u53bb\u5e7411\u6708\u5f00\u59cb\u3002<\/p>\n

Pacific Pediatric Neuro-Oncology Consortium (PNOC) \u8d5e\u52a9\u4e86\u6b63\u5728\u8fdb\u884c\u7684 II \u671f\u8bd5\u9a8c\u3002<\/p>\n

\u8fd9\u9879\u7814\u7a76\u7684\u521d\u6b65\u6570\u636e\u9884\u8ba1\u5728 2023 \u5e74\u4e0a\u534a\u5e74\u53d1\u5e03\u3002<\/p>\n

\u513f\u7ae5\u7684\u201c\u4e3b\u8981\u6b7b\u56e0\u4e4b\u4e00\u201d<\/h2>\n

Dun\u535a\u58eb\u8bf4\uff0c\u867d\u7136\u8111\u80bf\u7624\u662f\u513f\u7ae5\u4e2d\u7b2c\u4e8c\u5e38\u89c1\u7684\u764c\u75c7\uff0c\u4f46\u5b83\u4eec\u662f\u201c\u5bfc\u81f4\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u201d\uff08\u4e0e\u764c\u75c7\u76f8\u5173\uff09\uff0c\u5305\u62ec DIPG \u5728\u5185\u7684\u4fb5\u88ad\u6027\u75be\u75c5\u7684\u9884\u540e\u4ecd\u7136\u201c\u60b2\u60e8\u201d\u3002<\/p>\n

\u201c\u627e\u5230\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u81f3\u5173\u91cd\u8981\u3002\u201d<\/p>\n

\u201c\u8fd9\u9879\u7814\u7a76\u5408\u4f5c\u8054\u5408\u4e86\u8be5\u9886\u57df\u7684\u8bb8\u591a\u9886\u5148\u7684\u56fd\u9645\u4e2d\u5fc3\uff0c\u5e76\u90e8\u7f72\u4e86\u5c16\u7aef\u7684\u7814\u7a76\u5de5\u5177\u6765\u786e\u5b9a\u4e00\u79cd\u6781\u5177\u524d\u666f\u7684\u6cbb\u7597\u7ec4\u5408\u3002\u201d<\/p>\n

\u201c\u6211\u548c\u6211\u7684\u540c\u4e8b\u4eec\u5e0c\u671b\u770b\u5230\u8fd9\u4e9b\u5b9e\u9a8c\u5ba4\u53d1\u73b0\u5728\u6b63\u5728\u8fdb\u884c\u7684 PNOC \u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f97\u5230\u9a8c\u8bc1\uff0c\u8fd9\u53ef\u80fd\u5c06 ONC201\u548c paxalisib \u786e\u7acb\u4e3a\u6cbb\u7597\u53d7\u8fd9\u79cd\u75be\u75c5\u5f71\u54cd\u7684\u513f\u7ae5\u53ca\u5176\u5bb6\u4eba\u7684\u57fa\u77f3\uff0c\u201dDun \u535a\u58eb\u8bf4\u3002<\/p>\n

Paxalisib<\/h2>\n

Kazia \u7684\u4e3b\u8981\u836f\u7269 paxalisib \u662f PI3K\/Akt\/mTOR \u901a\u8def\u7684\u8111\u6e17\u900f\u6291\u5236\u5242\u3002\u8be5\u836f\u7269\u6700\u521d\u88ab\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff0c\u8fd9\u662f\u6210\u4eba\u4e2d\u6700\u5e38\u89c1\u548c\u6700\u5177\u4fb5\u88ad\u6027\u7684\u539f\u53d1\u6027\u8111\u764c\u3002<\/p>\n

\u8be5\u836f\u7269\u662f GBM AGILE \u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u4e34\u5e8a\u7814\u7a76\u7684\u4e00\u90e8\u5206\u3002<\/p>\n

GBM AGILE \u662f\u4e00\u9879\u591a\u836f\u7269\u5e73\u53f0\u7814\u7a76\uff0c\u65e8\u5728\u786e\u5b9a\u201c\u6709\u5e0c\u671b\u7684\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u65b0\u7597\u6cd5\u201d\u3002<\/p>\n

\u9664 paxalisib \u5916\uff0c\u5176\u4ed6\u4e24\u79cd\u5019\u9009\u836f\u7269\u4e5f\u53c2\u4e0e\u4e86\u8fd9\u9879\u7814\u7a76\uff0c\u5305\u62ec\u62dc\u8033\u7684 regorafenib \u548c Kintara Therapeutics \u7684 VAL-083\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5173\u4e8e Kazia Therapeutics (ASX: KZA) \u7684\u4e3b\u8981\u836f\u7269 paxalisib \u5728\u4e24\u79cd\u5f62\u5f0f\u7684\u513f\u7ae5\u8111\u764c\u4e2d\u7684\u6d3b\u6027\uff0c\u6b63\u5728\u5448\u73b0\u201c\u79ef\u6781\u6570\u636e\u201d\u3002 \u8be5\u516c\u53f8\u672c\u5468\u5728\u5fb7\u56fd\u4e3e\u884c\u7684\u7b2c 20 \u5c4a\u5c0f\u513f\u795e\u7ecf\u80bf\u7624\u5b66\u56fd\u9645\u7814\u8ba8\u4f1a (International Symposium on Pediatric Neuro-Oncology\uff1bISPNO) \u4e0a\u901a\u8fc7\u4e24\u6b21\u6f14\u8bb2\u5c55\u793a\u4e86\u8fd9\u4e9b\u6570\u636e\u3002 Johns Hopkins University\u7684 Jeffrey Rubens \u535a\u58eb\u8c08\u5230\u4e86 paxalisib \u4e0e\u7b2c\u4e8c\u79cd\u836f\u7269\u5728\u975e\u5178\u578b\u7578\u80ce\u7624\uff08teratoid\uff09\/\u6a2a\u7eb9\u808c\u7624\uff08rhabdoid\uff09\u52a8\u7269\u6a21\u578b\u4e2d\u7684\u6d3b\u6027\u3002 \u7b2c\u4e8c\u4e2a\u6f14\u8bb2\u6765\u81ea\u6fb3\u5927\u5229\u4e9a\u7ebd\u5361\u65af\u5c14\u5927\u5b66Hunter Medical Research Institute\u7684\u526f\u6559\u6388 Matt Dun\u3002 Dun\u535a\u58eb\u7684\u6f14\u8bb2\u6db5\u76d6\u4e86\u4e0e 10 \u4e2a\u56fd\u9645\u5b9e\u9a8c\u5ba4\u548c\u9886\u5148\u7684\u513f\u79d1\u4e2d\u5fc3\u5408\u4f5c\u5f00\u5c55\u7684\u5de5\u4f5c\u3002 \u8fd9\u9879\u5de5\u4f5c\u6d89\u53ca paxalisib \u4e0e ONC201 \u7684\u7ec4\u5408\uff0cONC201 \u662f Chimerix \u5236\u9020\u7684\u7528\u4e8e\u6cbb\u7597\u5f25\u6f2b\u6027\u5185\u5728\u8111\u6865\u80f6\u8d28\u7624 (DIPG) \u7684\u7814\u7a76\u6027\u7597\u6cd5\u3002 \u80bf\u7624\u201c\u663e\u7740\u51cf\u5c11\u201d \u6839\u636e Kazia \u7684\u8bf4\u6cd5\uff0c\u5f25\u6f2b\u6027\u4e2d\u7ebf\u795e\u7ecf\u80f6\u8d28\u7624 (DMG) \u662f\u4e00\u7ec4\u513f\u7ae5\u8111\u764c\uff0c\u5176\u4e2d\u5305\u62ec DIPG\uff0c\u5b83\u88ab\u5f52\u7c7b\u4e3a\u9ad8\u5ea6\u4fb5\u88ad\u6027\u4e14\u96be\u4ee5\u6cbb\u7597\u3002 \u6ca1\u6709\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u7684 DMG \u836f\u7269\u6cbb\u7597\uff0cDMG \u5360\u513f\u7ae5\u6240\u6709\u8111\u80bf\u7624\u7684… Continue reading Kazia Therapeutics \u63d0\u4f9b\u4e86\u5173\u4e8e paxalisib \u5728\u513f\u7ae5\u8111\u764c\u4e2d\u7684\u201c\u79ef\u6781\u6570\u636e\u201d<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":18022,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[498],"yoast_head":"\nKazia Therapeutics \u63d0\u4f9b\u4e86\u5173\u4e8e paxalisib \u5728\u513f\u7ae5\u8111\u764c\u4e2d\u7684\u201c\u79ef\u6781\u6570\u636e\u201d<\/title>\n<meta name=\"description\" content=\"\u5173\u4e8e Kazia Therapeutics (ASX: KZA) \u7684\u4e3b\u8981\u836f\u7269 paxalisib \u5728\u4e24\u79cd\u5f62\u5f0f\u7684\u513f\u7ae5\u8111\u764c\u4e2d\u7684\u6d3b\u6027\uff0c\u6b63\u5728\u5448\u73b0\u201c\u79ef\u6781\u6570\u636e\u201d\u3002\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta 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content=\"https:\/\/smallcapscn.x5view.co\/wp-content\/uploads\/2023\/08\/Kazia-Therapeutics-ASX-KZA-brain-tumour-positive-data-paxalisib-childhood-cancers.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"640\" \/>\n\t<meta property=\"og:image:height\" content=\"400\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Lorna Nicholas\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Lorna Nicholas\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/smallcapscn.x5view.co\/kazia-therapeutics-presents-positive-data-paxalisib-childhood-brain-cancers\/\",\"url\":\"https:\/\/smallcapscn.x5view.co\/kazia-therapeutics-presents-positive-data-paxalisib-childhood-brain-cancers\/\",\"name\":\"Kazia 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