{"id":5612,"date":"2022-08-08T00:02:09","date_gmt":"2022-08-08T00:02:09","guid":{"rendered":"\/\/smallcapscn.x5view.co\/?p=5612"},"modified":"2023-08-29T18:01:32","modified_gmt":"2023-08-29T18:01:32","slug":"kazia-therapeutics-reveals-response-rate-interim-data-brain-metastases-drug-trial","status":"publish","type":"post","link":"https:\/\/smallcapscn.x5view.co\/?p=5612","title":{"rendered":"Kazia Therapeutics \u5728\u8111\u8f6c\u79fb\u836f\u7269\u8bd5\u9a8c\u7684\u4e2d\u671f\u6570\u636e\u4e2d\u663e\u793a 100% \u7684\u53cd\u5e94\u7387"},"content":{"rendered":"

\u4ee5\u80bf\u7624\u5b66\u4e3a\u91cd\u70b9\u7684\u836f\u7269\u5f00\u53d1\u5546 Kazia Therapeutics (ASX: KZA) \u4ece\u5176\u4e3b\u5bfc\u836f\u7269 paxalisib \u8054\u5408\u653e\u7597\u6cbb\u7597\u8111\u8f6c\u79fb\u7624\u7684\u4e00\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u63d0\u4f9b\u4e86\u6709\u5e0c\u671b\u7684\u65b0\u6570\u636e\u3002<\/p>\n

\u8be5\u7814\u7a76\u7b2c\u4e00\u9636\u6bb5\u7684\u4e2d\u671f\u6570\u636e\u7531\u7ebd\u7ea6Memorial Sloan Kettering Cancer Centre \u7684 Jonathan Yang \u535a\u58eb\u9886\u5bfc\uff0c\u62a5\u544a\u79f0\u6240\u6709 9 \u540d\u8bc4\u4f30\u60a3\u8005\u90fd\u5bf9\u6cbb\u7597\u6709\u5b8c\u5168\u6216\u90e8\u5206\u53cd\u5e94\uff0c\u603b\u4f53\u53cd\u5e94\u7387\u4e3a 100%\u3002<\/p>\n

Kazia \u8bf4\uff0c\u8fd9\u53ef\u4ee5\u4e0e\u4ec5\u4e0e\u5168\u8111\u653e\u7597\u76f8\u5173\u7684\u5178\u578b\u603b\u4f53\u53cd\u5e94\u7387\u8fdb\u884c\u6bd4\u8f83\uff0c\u5728\u5df2\u53d1\u8868\u7684\u7814\u7a76\u4e2d\uff0c\u8be5\u53cd\u5e94\u7387\u901a\u5e38\u5728 20-45% \u4e4b\u95f4\u3002<\/p>\n

Kazia \u9996\u5e2d\u6267\u884c\u5b98 James Garner \u535a\u58eb\u8868\u793a\uff0c\u8be5\u516c\u53f8\u5bf9\u8fd9\u4e9b\u6570\u636e\u4ee5\u53ca\u5b83\u53ef\u80fd\u5411\u8fd9\u4e00\u201c\u5927\u91cf\u548c\u9ad8\u9700\u6c42\u201d\u60a3\u8005\u7fa4\u4f53\u8868\u660e\u7684\u6f5c\u5728\u5229\u76ca\u611f\u5230\u9f13\u821e\u3002<\/p>\n

\u201c\u653e\u5c04\u7597\u6cd5\u662f\u8111\u8f6c\u79fb\u6cbb\u7597\u8303\u5f0f\u4e2d\u666e\u904d\u5b58\u5728\u7684\u7ec4\u6210\u90e8\u5206\uff0c\u4f46\u8010\u836f\u6027\u5f88\u5e38\u89c1\u3002\u6768\u535a\u58eb\u7684\u7814\u7a76\u8868\u660e\uff0cpaxalisib \u53ef\u80fd\u6709\u52a9\u4e8e\u589e\u5f3a\u653e\u5c04\u6cbb\u7597\u7684\u6548\u679c\uff0c\u8fd9\u662f\u4e00\u4e2a\u975e\u5e38\u6709\u5e0c\u671b\u7684\u4fe1\u53f7\u3002\u201d<\/p>\n

\u8be5\u7814\u7a76\u7b2c\u4e8c\u9636\u6bb5\u7684\u53e6\u5916 12 \u540d\u60a3\u8005\u7684\u62db\u52df\u5de5\u4f5c\u5df2\u7ecf\u5728\u8fdb\u884c\u4e2d\uff0cKazia \u9884\u8ba1\u8be5\u6269\u5c55\u9636\u6bb5\u7684\u521d\u6b65\u6570\u636e\u5c06\u5728 2023 \u5e74\u8fdb\u884c\u3002<\/p>\n

Garner \u535a\u58eb\u8fd8\u900f\u9732\uff0c\u8054\u76df\u6b63\u5728\u8fdb\u884c\u7684\u8111\u8f6c\u79fb\u7814\u7a76\u5df2\u8fdb\u5165\u4e73\u817a\u764c\u961f\u5217\u7684\u6269\u5c55\u9636\u6bb5\u3002<\/p>\n

\u201c\u8fd9\u73b0\u5728\u4ee3\u8868\u4e86 paxalisib \u5728\u8111\u8f6c\u79fb\u4e2d\u7684\u7b2c\u4e8c\u4e2a\u79ef\u6781\u4fe1\u53f7\uff0c\u6211\u4eec\u8d8a\u6765\u8d8a\u76f8\u4fe1\u8fd9\u5bf9\u5019\u9009\u4ea7\u54c1\u6765\u8bf4\u662f\u4e00\u4e2a\u975e\u5e38\u6709\u5e0c\u671b\u7684\u673a\u4f1a\uff0c\u201d\u4ed6\u8bf4\u3002<\/p>\n

\u4e2d\u671f\u4e1a\u7ee9<\/h2>\n

Kazia \u7684\u7b2c\u4e00\u9636\u6bb5 paxalisib \u8bd5\u9a8c\u8bbe\u8ba1\u5206\u4e3a\u4e24\u4e2a\u9636\u6bb5\uff1a\u521d\u59cb\u63a2\u7d22\u9636\u6bb5\u548c\u786e\u8ba4\u6269\u5c55\u9636\u6bb5\u3002<\/p>\n

\u8fc4\u4eca\u4e3a\u6b62\uff0c\u8be5\u8bd5\u9a8c\u7684\u60a3\u8005\u5305\u62ec\u4e00\u7cfb\u5217\u539f\u53d1\u6027\u80bf\u7624\uff0c\u5176\u4e2d\u4e73\u817a\u764c\u662f\u6700\u5e38\u89c1\u7684\uff0c\u5360\u60a3\u8005\u7684\u4e09\u5206\u4e4b\u4e00\u3002<\/p>\n

\u5728\u521d\u59cb\u9636\u6bb5\u62db\u52df\u7684 12 \u540d\u60a3\u8005\u4e2d\uff0c\u6709 9 \u540d\u53ef\u8bc4\u4f30\u7597\u6548\u3002\u6240\u6709 9 \u4eba\u90fd\u5bf9 paxalisib \u548c\u653e\u7597\u7684\u8054\u5408\u6cbb\u7597\u8868\u73b0\u51fa\u201c\u5b8c\u5168\u6216\u90e8\u5206\u53cd\u5e94\u201d\u3002<\/p>\n

\u6839\u636e Kazia \u7684\u8bf4\u6cd5\uff0cpaxalisib \u8054\u5408\u7528\u836f\u7684\u5b89\u5168\u6027\u4e0e\u5176\u4ed6\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u5355\u836f\u6cbb\u7597\u7ecf\u9a8c\u5927\u4f53\u4e00\u81f4\uff0c\u5e76\u4e14\u8bc1\u5b9e\u4e86\u6bcf\u5929 45mg \u7684\u6700\u5927\u8010\u53d7\u5242\u91cf\u4e0e\u653e\u7597\u8054\u5408\u7528\u836f\u3002<\/p>\n

\u672c\u5468\u4f1a\u8bae\u4e0a\u516c\u5e03\u7684\u6570\u636e<\/h2>\n

\u8be5\u4e2d\u671f\u6570\u636e\u5df2\u88ab\u63a5\u53d7\uff0c\u5728\u672c\u5468\u665a\u4e9b\u65f6\u5019\u5728\u52a0\u62ff\u5927\u591a\u4f26\u591a\u4e3e\u884c\u7684 2022 \u5e74 CNS Clinical Trials and Brain Metastases\u5e74\u5ea6\u4f1a\u8bae\u4e0a\u53d1\u8868\u3002<\/p>\n

Kazia \u8868\u793a\uff0c\u6269\u5c55\u9636\u6bb5\u4e4b\u540e\u7684\u4e0b\u4e00\u6b65\u5c06\u662f\u4e0e\u79d1\u5b66\u987e\u95ee\u548c\u76d1\u7ba1\u987e\u95ee\u8ba8\u8bba\u6765\u81ea\u8be5\u7814\u7a76\u7684\u65b0\u6570\u636e\uff0c\u4ee5\u53ca\u8111\u8f6c\u79fb\u7684\u5176\u4ed6\u7814\u7a76\uff0c\u672a\u6765\u53ef\u80fd\u4f1a\u4e0e FDA \u534f\u5546\u3002<\/p>\n

\u5927\u7ea6\u4e94\u5206\u4e4b\u4e00\u7684\u764c\u75c7\u60a3\u8005\u4f1a\u53d1\u751f\u8111\u8f6c\u79fb<\/h2>\n

\u6839\u636e Kazia \u7684\u8bf4\u6cd5\uff0c\u5927\u7ea6 20% \u7684\u764c\u75c7\u60a3\u8005\u4f1a\u5728\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u4e2d\u53d1\u5c55\u51fa\u7ee7\u53d1\u6027\u80bf\u7624\uff0c\u5373\u8111\u8f6c\u79fb\u7624\u3002\u6700\u5e38\u89c1\u7684\u6269\u6563\u5230\u5927\u8111\u7684\u539f\u53d1\u6027\u80bf\u7624\u5305\u62ec\u80ba\u764c\u3001\u4e73\u817a\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u9ed1\u8272\u7d20\u7624\u548c\u80be\u7ec6\u80de\u764c\u3002<\/p>\n

\u5728\u7f8e\u56fd\uff0c\u6bcf\u5e74\u7ea6\u6709 200,000 \u540d\u764c\u75c7\u60a3\u8005\u53d1\u751f\u8111\u8f6c\u79fb\u3002\u5b83\u4eec\u901a\u5e38\u901a\u8fc7\u653e\u5c04\u6cbb\u7597\u8fdb\u884c\u7ba1\u7406\uff0c\u4f46\u901a\u5e38\u5f88\u96be\u6cbb\u7597\u5e76\u4e14\u4e0e\u9884\u540e\u4e0d\u826f\u6709\u5173\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u4ee5\u80bf\u7624\u5b66\u4e3a\u91cd\u70b9\u7684\u836f\u7269\u5f00\u53d1\u5546 Kazia Therapeutics (ASX: KZA) \u4ece\u5176\u4e3b\u5bfc\u836f\u7269 paxalisib \u8054\u5408\u653e\u7597\u6cbb\u7597\u8111\u8f6c\u79fb\u7624\u7684\u4e00\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u63d0\u4f9b\u4e86\u6709\u5e0c\u671b\u7684\u65b0\u6570\u636e\u3002 \u8be5\u7814\u7a76\u7b2c\u4e00\u9636\u6bb5\u7684\u4e2d\u671f\u6570\u636e\u7531\u7ebd\u7ea6Memorial Sloan Kettering Cancer Centre \u7684 Jonathan Yang \u535a\u58eb\u9886\u5bfc\uff0c\u62a5\u544a\u79f0\u6240\u6709 9 \u540d\u8bc4\u4f30\u60a3\u8005\u90fd\u5bf9\u6cbb\u7597\u6709\u5b8c\u5168\u6216\u90e8\u5206\u53cd\u5e94\uff0c\u603b\u4f53\u53cd\u5e94\u7387\u4e3a 100%\u3002 Kazia \u8bf4\uff0c\u8fd9\u53ef\u4ee5\u4e0e\u4ec5\u4e0e\u5168\u8111\u653e\u7597\u76f8\u5173\u7684\u5178\u578b\u603b\u4f53\u53cd\u5e94\u7387\u8fdb\u884c\u6bd4\u8f83\uff0c\u5728\u5df2\u53d1\u8868\u7684\u7814\u7a76\u4e2d\uff0c\u8be5\u53cd\u5e94\u7387\u901a\u5e38\u5728 20-45% \u4e4b\u95f4\u3002 Kazia \u9996\u5e2d\u6267\u884c\u5b98 James Garner \u535a\u58eb\u8868\u793a\uff0c\u8be5\u516c\u53f8\u5bf9\u8fd9\u4e9b\u6570\u636e\u4ee5\u53ca\u5b83\u53ef\u80fd\u5411\u8fd9\u4e00\u201c\u5927\u91cf\u548c\u9ad8\u9700\u6c42\u201d\u60a3\u8005\u7fa4\u4f53\u8868\u660e\u7684\u6f5c\u5728\u5229\u76ca\u611f\u5230\u9f13\u821e\u3002 \u201c\u653e\u5c04\u7597\u6cd5\u662f\u8111\u8f6c\u79fb\u6cbb\u7597\u8303\u5f0f\u4e2d\u666e\u904d\u5b58\u5728\u7684\u7ec4\u6210\u90e8\u5206\uff0c\u4f46\u8010\u836f\u6027\u5f88\u5e38\u89c1\u3002\u6768\u535a\u58eb\u7684\u7814\u7a76\u8868\u660e\uff0cpaxalisib \u53ef\u80fd\u6709\u52a9\u4e8e\u589e\u5f3a\u653e\u5c04\u6cbb\u7597\u7684\u6548\u679c\uff0c\u8fd9\u662f\u4e00\u4e2a\u975e\u5e38\u6709\u5e0c\u671b\u7684\u4fe1\u53f7\u3002\u201d \u8be5\u7814\u7a76\u7b2c\u4e8c\u9636\u6bb5\u7684\u53e6\u5916 12 \u540d\u60a3\u8005\u7684\u62db\u52df\u5de5\u4f5c\u5df2\u7ecf\u5728\u8fdb\u884c\u4e2d\uff0cKazia \u9884\u8ba1\u8be5\u6269\u5c55\u9636\u6bb5\u7684\u521d\u6b65\u6570\u636e\u5c06\u5728 2023 \u5e74\u8fdb\u884c\u3002 Garner \u535a\u58eb\u8fd8\u900f\u9732\uff0c\u8054\u76df\u6b63\u5728\u8fdb\u884c\u7684\u8111\u8f6c\u79fb\u7814\u7a76\u5df2\u8fdb\u5165\u4e73\u817a\u764c\u961f\u5217\u7684\u6269\u5c55\u9636\u6bb5\u3002 \u201c\u8fd9\u73b0\u5728\u4ee3\u8868\u4e86 paxalisib \u5728\u8111\u8f6c\u79fb\u4e2d\u7684\u7b2c\u4e8c\u4e2a\u79ef\u6781\u4fe1\u53f7\uff0c\u6211\u4eec\u8d8a\u6765\u8d8a\u76f8\u4fe1\u8fd9\u5bf9\u5019\u9009\u4ea7\u54c1\u6765\u8bf4\u662f\u4e00\u4e2a\u975e\u5e38\u6709\u5e0c\u671b\u7684\u673a\u4f1a\uff0c\u201d\u4ed6\u8bf4\u3002 \u4e2d\u671f\u4e1a\u7ee9 Kazia \u7684\u7b2c\u4e00\u9636\u6bb5 paxalisib \u8bd5\u9a8c\u8bbe\u8ba1\u5206\u4e3a\u4e24\u4e2a\u9636\u6bb5\uff1a\u521d\u59cb\u63a2\u7d22\u9636\u6bb5\u548c\u786e\u8ba4\u6269\u5c55\u9636\u6bb5\u3002 \u8fc4\u4eca\u4e3a\u6b62\uff0c\u8be5\u8bd5\u9a8c\u7684\u60a3\u8005\u5305\u62ec\u4e00\u7cfb\u5217\u539f\u53d1\u6027\u80bf\u7624\uff0c\u5176\u4e2d\u4e73\u817a\u764c\u662f\u6700\u5e38\u89c1\u7684\uff0c\u5360\u60a3\u8005\u7684\u4e09\u5206\u4e4b\u4e00\u3002 \u5728\u521d\u59cb\u9636\u6bb5\u62db\u52df\u7684 12 \u540d\u60a3\u8005\u4e2d\uff0c\u6709 9 \u540d\u53ef\u8bc4\u4f30\u7597\u6548\u3002\u6240\u6709 9 \u4eba\u90fd\u5bf9… Continue reading Kazia Therapeutics \u5728\u8111\u8f6c\u79fb\u836f\u7269\u8bd5\u9a8c\u7684\u4e2d\u671f\u6570\u636e\u4e2d\u663e\u793a 100% \u7684\u53cd\u5e94\u7387<\/span><\/a><\/p>\n","protected":false},"author":5,"featured_media":18045,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[498],"yoast_head":"\nKazia Therapeutics \u5728\u8111\u8f6c\u79fb\u836f\u7269\u8bd5\u9a8c\u7684\u4e2d\u671f\u6570\u636e\u4e2d\u663e\u793a 100% \u7684\u53cd\u5e94\u7387<\/title>\n<meta name=\"description\" content=\"\u4ee5\u80bf\u7624\u5b66\u4e3a\u91cd\u70b9\u7684\u836f\u7269\u5f00\u53d1\u5546 Kazia Therapeutics (ASX: KZA) \u4ece\u5176\u4e3b\u5bfc\u836f\u7269 paxalisib \u8054\u5408\u653e\u7597\u6cbb\u7597\u8111\u8f6c\u79fb\u7624\u7684\u4e00\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u63d0\u4f9b\u4e86\u6709\u5e0c\u671b\u7684\u65b0\u6570\u636e\u3002\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kazia Therapeutics \u5728\u8111\u8f6c\u79fb\u836f\u7269\u8bd5\u9a8c\u7684\u4e2d\u671f\u6570\u636e\u4e2d\u663e\u793a 100% \u7684\u53cd\u5e94\u7387\" \/>\n<meta property=\"og:description\" content=\"\u4ee5\u80bf\u7624\u5b66\u4e3a\u91cd\u70b9\u7684\u836f\u7269\u5f00\u53d1\u5546 Kazia Therapeutics (ASX: KZA) \u4ece\u5176\u4e3b\u5bfc\u836f\u7269 paxalisib 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