{"id":5702,"date":"2022-08-25T23:57:23","date_gmt":"2022-08-25T23:57:23","guid":{"rendered":"\/\/smallcapscn.x5view.co\/?p=5702"},"modified":"2023-08-29T18:01:32","modified_gmt":"2023-08-29T18:01:32","slug":"vectus-biosystems-unveils-more-promising-results-phase-1-clinical-trial","status":"publish","type":"post","link":"https:\/\/smallcapscn.x5view.co\/?p=5702","title":{"rendered":"Vectus Biosystems \u4ece 1 \u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u516c\u5e03\u4e86\u66f4\u6709\u5e0c\u671b\u7684\u7ed3\u679c"},"content":{"rendered":"

\u5728\u8bf1\u4eba\u7684\u5236\u836f\u5408\u4f5c\u4f19\u4f34\u4e4b\u524d\uff0cVectus Biosystems (ASX: VBS) \u76f8\u4fe1\uff0c\u5176\u6cbb\u7597\u7ea4\u7ef4\u5316\u548c\u9ad8\u8840\u538b\u7684\u4e3b\u8981\u836f\u7269 VB0004 \u6b63\u5728\u8fdb\u884c\u7684 1 \u671f\u8bd5\u9a8c\u5c06\u7ee7\u7eed\u4ea7\u751f\u79ef\u6781\u7684\u7ed3\u679c\u3002<\/p>\n

\u8fd9\u5bb6\u751f\u7269\u6280\u672f\u516c\u53f8\u5f00\u53d1\u4e86\u5176\u5148\u5bfc\u5316\u5408\u7269 VB0004\uff0c\u7528\u4e8e\u6cbb\u7597\u9ad8\u8840\u538b\uff08\u9ad8\u8840\u538b\uff09\u548c\u7ea4\u7ef4\u5316\uff08\u7528\u75a4\u75d5\u7ec4\u7ec7\u66ff\u4ee3\u529f\u80fd\u7ec4\u7ec7\uff09\uff0c\u5176\u4e2d\u5305\u62ec\u6cbb\u7597\u5fc3\u810f\u3001\u80be\u810f\u548c\u809d\u810f\u75be\u75c5\u3002<\/p>\n

\u5b83\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\uff0c\u4ee5\u7814\u7a76\u5355\u5242\u91cf\u548c\u91cd\u590d\u5242\u91cf\u8be5\u836f\u7269\u5728\u6b63\u5e38\u4eba\u7c7b\u5fd7\u613f\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u3002\u968f\u540e\u5c06\u7814\u7a76\u4e24\u7ec4\u5177\u6709\u4f4e\u5fc3\u8840\u7ba1\u98ce\u9669\u7684\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u9ad8\u8840\u538b\u60a3\u8005\u3002<\/p>\n

\u5728\u5176\u6700\u65b0\u66f4\u65b0\u4e2d\uff0c\u8be5\u516c\u53f8\u62a5\u544a\u4e86\u8be5\u8bd5\u9a8c\u7684\u591a\u6b21\u9012\u589e\u5242\u91cf\uff08 MAD \uff09\u90e8\u5206\u4e09\u4e2a\u8ba1\u5212\u961f\u5217\u4e2d\u7684\u7b2c\u4e8c\u4e2a\u6ca1\u6709\u91cd\u5927\u4e0d\u826f\u4e8b\u4ef6\u3002\u8fd9\u4e00\u6d88\u606f\u662f\u5728\u5148\u524d\u7684\u8bd5\u9a8c\u6210\u529f\u4e4b\u540e\u53d1\u5e03\u7684\uff0c\u5305\u62ec\u5728\u7814\u7a76\u7684\u5355\u6b21\u9012\u589e\u5242\u91cf (SAD) \u90e8\u5206\u671f\u95f4\u7ecf\u5386\u7684\u4e0d\u826f\u4e8b\u4ef6\u7684\u96f6\u62a5\u544a\u3002<\/p>\n

\u6b64\u5916\uff0c\u8be5\u6570\u636e\u63d0\u4f9b\u7684\u8bc1\u636e\u8868\u660e VB0004 \u53ef\u4ee5\u6bcf\u5929\u7ed9\u836f\u4e00\u6b21\uff0c\u8fd9\u662f\u6cbb\u7597\u9ad8\u8840\u538b\u3001\u5fc3\u529b\u8870\u7aed\u3001\u80be\u8870\u7aed\u548c\u80ba\u7ea4\u7ef4\u5316\u7b49\u6162\u6027\u75be\u75c5\u836f\u7269\u7684\u7406\u60f3\u7279\u5f81\u3002<\/p>\n

\u672c\u6708\u65e9\u4e9b\u65f6\u5019\uff0cTrial Safety Review Committee \u5728\u5ba1\u67e5\u4e86\u6240\u6709\u4e94\u4e2a SAD \u961f\u5217\u548c\u4e09\u4e2a\u8ba1\u5212\u4e2d\u7684 MAD \u961f\u5217\u4e2d\u7684\u524d\u4e24\u4e2a\u961f\u5217\u7684\u6570\u636e\u540e\uff0c\u5141\u8bb8\u7b2c\u4e09\u4e2a\u4e5f\u662f\u6700\u540e\u4e00\u4e2a MAD \u961f\u5217\u7ee7\u7eed\u8fdb\u884c\u3002\u56db\u540d\u53c2\u4e0e\u8005\u6ce8\u518c\u5e76\u5f00\u59cb\u4e86\u8fd9\u9879\u7814\u7a76\uff0c\u4ed6\u4eec\u6bcf\u5929\u63a5\u53d7 100 \u6beb\u514b\u7684 VB0004\uff08\u6216\u5b89\u6170\u5242\uff09\uff0c\u6301\u7eed 14 \u5929\u3002<\/p>\n

Vectus \u6b63\u6ee1\u6000\u671f\u5f85\u5730\u7b49\u5f85\u6570\u636e\uff0c\u76f8\u4fe1\u8fc4\u4eca\u4e3a\u6b62\u7684\u7ed3\u679c\u5df2\u7ecf\u4f7f\u5176\u5904\u4e8e\u5438\u5f15\u5927\u578b\u5236\u836f\u516c\u53f8\u5174\u8da3\u7684\u6709\u5229\u4f4d\u7f6e\u3002<\/p>\n

\u6700\u8fd1\u7684\u7ed3\u679c<\/h2>\n

Vectus \u7684 1\/1b \u671f\u5355\u4e2d\u5fc3\u3001\u53cc\u76f2\u3001\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u5242\u91cf\u9012\u589e\u7814\u7a76\u7684\u6700\u65b0\u7ed3\u679c\u8868\u660e\uff0c\u8fde\u7eed 14 \u5929\u670d\u7528 30mg \u5242\u91cf\u7684 VB0004 \u4e0d\u4f1a\u5bfc\u81f4\u660e\u663e\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5e76\u8868\u660e\u51e0\u4e4e\u6ca1\u6709\u79ef\u7d2f\u836f\u7269\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u800c\u53d1\u751f\u3002<\/p>\n

\u5728\u7b2c\u4e8c\u4e2a MAD \u961f\u5217\u4e2d\uff0c\u4e2d\u671f\u836f\u4ee3\u52a8\u529b\u5b66\u5206\u6790\u8fd8\u8bc1\u5b9e\uff0cVB0004 \u8fbe\u5230\u6700\u5927\u6d53\u5ea6\u7684\u65f6\u95f4\u53d1\u751f\u5728\u7ed9\u836f\u540e 6 \u81f3 8 \u5c0f\u65f6\uff0c\u8840\u6d46\u534a\u8870\u671f\uff08\u836f\u7269\u8840\u6d46\u6d53\u5ea6\u964d\u4f4e 50% \u6240\u9700\u7684\u65f6\u95f4\uff09\u4ecb\u4e8e\u7b2c\u4e00\u5929\u548c\u7b2c 14 \u5929 10-15 \u5c0f\u65f6\u3002<\/p>\n

\u8be5\u7814\u7a76\u7684\u591a\u5242\u91cf\u90e8\u5206\u662f\u5728\u4eca\u5e74\u4e0a\u534a\u5e74\u8fdb\u884c\u7684\u5355\u5242\u91cf\u7814\u7a76\u4e4b\u540e\u8fdb\u884c\u7684\uff0c\u8be5\u7814\u7a76\u8fd8\u62a5\u544a\u4e86\u5373\u4f7f\u5728 300 \u6beb\u514b VB0004 \u7684\u6700\u9ad8\u5355\u5242\u91cf\u4e0b\u4e5f\u6ca1\u6709\u660e\u663e\u7684\u4e0d\u826f\u4e8b\u4ef6\u3002 SAD \u961f\u5217\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u5206\u6790\u63ed\u793a\u4e86\u4e0e MAD \u961f\u5217\u76f8\u4f3c\u7684\u6570\u636e\uff086 \u5c0f\u65f6\u8fbe\u5230\u6700\u5927\u8840\u6d46\u6d53\u5ea6\uff0c10-15 \u5c0f\u65f6\u6d53\u5ea6\u964d\u4f4e\u4e00\u534a\uff09\uff0c\u4e3a VB0004 \u9002\u5408\u6bcf\u65e5\u4e00\u6b21\u7ed9\u836f\u63d0\u4f9b\u4e86\u6709\u5e0c\u671b\u7684\u8bc1\u636e\u3002<\/p>\n

\u6f5c\u5728\u7684\u8f6c\u5316\u6cbb\u7597<\/h2>\n

\u5728\u8bc4\u8bba\u65e9\u671f\u7684\u5355\u5242\u91cf\u7ed3\u679c\u65f6\uff0cVectus \u4e3b\u5e2d Ron Shnier \u535a\u58eb\u5c06 VB0004 \u63cf\u8ff0\u4e3a\u201c\u771f\u6b63\u7684\u8f6c\u5316\u836f\u7269\u201d\uff0c\u5b83\u6709\u53ef\u80fd\u201c\u4e0d\u4ec5\u51cf\u7f13\u75be\u75c5\u8fdb\u5c55\uff0c\u800c\u4e14\u5b9e\u9645\u4e0a\u53ef\u80fd\u63d0\u4f9b\u73b0\u6709\u635f\u4f24\u7684\u4e34\u5e8a\u9006\u8f6c\u201d\u3002<\/p>\n

Vectus \u5f97\u5230\u975e\u6267\u884c\u8463\u4e8b\u548c\u7b2c\u4e8c\u5927\u80a1\u4e1c Maurie Stang \u7684\u652f\u6301\uff0c\u4ed6\u4e5f\u662f\u4ef7\u503c 13 \u4ebf\u6fb3\u5143\u7684\u6d88\u6bd2\u8bbe\u5907\u516c\u53f8 Nanosonics (ASX: NAN) \u7684\u8463\u4e8b\u957f\u3002 Stang \u5148\u751f\u6700\u8fd1\u544a\u8bc9\u5a92\u4f53\uff0c\u5982\u679c VB0004 \u7ee7\u7eed\u6cbf\u7528\u76ee\u524d\u7684\u9053\u8def\uff0c\u5b83\u53ef\u80fd\u4f1a\u6210\u4e3a\u201c\u6765\u81ea\u6fb3\u5927\u5229\u4e9a\u7684\u6700\u5927\u548c\u6700\u91cd\u8981\u7684\u836f\u7269\u201d\u3002<\/p>\n

\u7ea4\u7ef4\u5316\u662f\u6307\u5668\u5b98\uff08\u5982\u5fc3\u810f\u3001\u80ba\u3001\u80be\u810f\u3001\u809d\u810f\u7b49\uff09\u4e2d\u7684\u529f\u80fd\u7ec4\u7ec7\u88ab\u75a4\u75d5\u7ec4\u7ec7\u66ff\u4ee3\uff0c\u5bfc\u81f4\u529f\u80fd\u4e27\u5931\u3002<\/p>\n

\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u7684\u6570\u636e\u8868\u660e\uff0c\u7ea4\u7ef4\u5316\u5728\u5168\u7403\u8d85\u8fc7 40% \u7684\u6b7b\u4ea1\u4e2d\u8d77\u4f5c\u7528\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5728\u8bf1\u4eba\u7684\u5236\u836f\u5408\u4f5c\u4f19\u4f34\u4e4b\u524d\uff0cVectus Biosystems (ASX: VBS) \u76f8\u4fe1\uff0c\u5176\u6cbb\u7597\u7ea4\u7ef4\u5316\u548c\u9ad8\u8840\u538b\u7684\u4e3b\u8981\u836f\u7269 VB0004 \u6b63\u5728\u8fdb\u884c\u7684 1 \u671f\u8bd5\u9a8c\u5c06\u7ee7\u7eed\u4ea7\u751f\u79ef\u6781\u7684\u7ed3\u679c\u3002 \u8fd9\u5bb6\u751f\u7269\u6280\u672f\u516c\u53f8\u5f00\u53d1\u4e86\u5176\u5148\u5bfc\u5316\u5408\u7269 VB0004\uff0c\u7528\u4e8e\u6cbb\u7597\u9ad8\u8840\u538b\uff08\u9ad8\u8840\u538b\uff09\u548c\u7ea4\u7ef4\u5316\uff08\u7528\u75a4\u75d5\u7ec4\u7ec7\u66ff\u4ee3\u529f\u80fd\u7ec4\u7ec7\uff09\uff0c\u5176\u4e2d\u5305\u62ec\u6cbb\u7597\u5fc3\u810f\u3001\u80be\u810f\u548c\u809d\u810f\u75be\u75c5\u3002 \u5b83\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\uff0c\u4ee5\u7814\u7a76\u5355\u5242\u91cf\u548c\u91cd\u590d\u5242\u91cf\u8be5\u836f\u7269\u5728\u6b63\u5e38\u4eba\u7c7b\u5fd7\u613f\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u3002\u968f\u540e\u5c06\u7814\u7a76\u4e24\u7ec4\u5177\u6709\u4f4e\u5fc3\u8840\u7ba1\u98ce\u9669\u7684\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u9ad8\u8840\u538b\u60a3\u8005\u3002 \u5728\u5176\u6700\u65b0\u66f4\u65b0\u4e2d\uff0c\u8be5\u516c\u53f8\u62a5\u544a\u4e86\u8be5\u8bd5\u9a8c\u7684\u591a\u6b21\u9012\u589e\u5242\u91cf\uff08 MAD \uff09\u90e8\u5206\u4e09\u4e2a\u8ba1\u5212\u961f\u5217\u4e2d\u7684\u7b2c\u4e8c\u4e2a\u6ca1\u6709\u91cd\u5927\u4e0d\u826f\u4e8b\u4ef6\u3002\u8fd9\u4e00\u6d88\u606f\u662f\u5728\u5148\u524d\u7684\u8bd5\u9a8c\u6210\u529f\u4e4b\u540e\u53d1\u5e03\u7684\uff0c\u5305\u62ec\u5728\u7814\u7a76\u7684\u5355\u6b21\u9012\u589e\u5242\u91cf (SAD) \u90e8\u5206\u671f\u95f4\u7ecf\u5386\u7684\u4e0d\u826f\u4e8b\u4ef6\u7684\u96f6\u62a5\u544a\u3002 \u6b64\u5916\uff0c\u8be5\u6570\u636e\u63d0\u4f9b\u7684\u8bc1\u636e\u8868\u660e VB0004 \u53ef\u4ee5\u6bcf\u5929\u7ed9\u836f\u4e00\u6b21\uff0c\u8fd9\u662f\u6cbb\u7597\u9ad8\u8840\u538b\u3001\u5fc3\u529b\u8870\u7aed\u3001\u80be\u8870\u7aed\u548c\u80ba\u7ea4\u7ef4\u5316\u7b49\u6162\u6027\u75be\u75c5\u836f\u7269\u7684\u7406\u60f3\u7279\u5f81\u3002 \u672c\u6708\u65e9\u4e9b\u65f6\u5019\uff0cTrial Safety Review Committee \u5728\u5ba1\u67e5\u4e86\u6240\u6709\u4e94\u4e2a SAD \u961f\u5217\u548c\u4e09\u4e2a\u8ba1\u5212\u4e2d\u7684 MAD \u961f\u5217\u4e2d\u7684\u524d\u4e24\u4e2a\u961f\u5217\u7684\u6570\u636e\u540e\uff0c\u5141\u8bb8\u7b2c\u4e09\u4e2a\u4e5f\u662f\u6700\u540e\u4e00\u4e2a MAD \u961f\u5217\u7ee7\u7eed\u8fdb\u884c\u3002\u56db\u540d\u53c2\u4e0e\u8005\u6ce8\u518c\u5e76\u5f00\u59cb\u4e86\u8fd9\u9879\u7814\u7a76\uff0c\u4ed6\u4eec\u6bcf\u5929\u63a5\u53d7 100 \u6beb\u514b\u7684 VB0004\uff08\u6216\u5b89\u6170\u5242\uff09\uff0c\u6301\u7eed 14 \u5929\u3002 Vectus \u6b63\u6ee1\u6000\u671f\u5f85\u5730\u7b49\u5f85\u6570\u636e\uff0c\u76f8\u4fe1\u8fc4\u4eca\u4e3a\u6b62\u7684\u7ed3\u679c\u5df2\u7ecf\u4f7f\u5176\u5904\u4e8e\u5438\u5f15\u5927\u578b\u5236\u836f\u516c\u53f8\u5174\u8da3\u7684\u6709\u5229\u4f4d\u7f6e\u3002 \u6700\u8fd1\u7684\u7ed3\u679c Vectus \u7684 1\/1b \u671f\u5355\u4e2d\u5fc3\u3001\u53cc\u76f2\u3001\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u5242\u91cf\u9012\u589e\u7814\u7a76\u7684\u6700\u65b0\u7ed3\u679c\u8868\u660e\uff0c\u8fde\u7eed 14 \u5929\u670d\u7528 30mg \u5242\u91cf\u7684 VB0004 \u4e0d\u4f1a\u5bfc\u81f4\u660e\u663e\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5e76\u8868\u660e\u51e0\u4e4e\u6ca1\u6709\u79ef\u7d2f\u836f\u7269\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u800c\u53d1\u751f\u3002 \u5728\u7b2c\u4e8c\u4e2a MAD \u961f\u5217\u4e2d\uff0c\u4e2d\u671f\u836f\u4ee3\u52a8\u529b\u5b66\u5206\u6790\u8fd8\u8bc1\u5b9e\uff0cVB0004 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