{"id":6788,"date":"2023-05-09T01:41:34","date_gmt":"2023-05-09T01:41:34","guid":{"rendered":"\/\/smallcapscn.x5view.co\/?p=6788"},"modified":"2023-08-29T17:57:51","modified_gmt":"2023-08-29T17:57:51","slug":"radiopharm-theranostics-orphan-drug-designation-rad-301-treat-pancreatic-cancers","status":"publish","type":"post","link":"https:\/\/smallcapscn.x5view.co\/?p=6788","title":{"rendered":"Radiopharm Theranostics\u4e3a\u6cbb\u7597\u80f0\u817a\u764c\u7684RAD 301\u83b7\u5f97\u5b64\u513f\u836f\u8ba4\u5b9a"},"content":{"rendered":"<p>Radiopharm Theranostics (ASX: RAD) \u7684Ga68-Trivehexin\uff08RAD 301\uff09\u653e\u5c04\u6027\u836f\u7269\u6280\u672f\u5df2\u88ab\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\u6388\u4e88\u5b64\u513f\u836f\u7684\u79f0\u53f7\uff0c\u7528\u4e8e\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\uff08PDAC\uff09\u60a3\u8005\u7684\u6210\u50cf\u3002<\/p>\n<p>Trivehexin\u662f\u4e00\u79cd\u4e13\u6709\u7684\u80bd\u57fa\u5206\u5b50\uff0c\u9488\u5bf9\u03b1v\u03b26-\u6574\u5408\u7d20\u7684\u7ec6\u80de\u6807\u8bb0\u7269\uff0c\u7528\u4e8e\u80bf\u7624\u4fb5\u88ad\u548c\u8f6c\u79fb\u6027\u751f\u957f\u3002<\/p>\n<p>\u8be5\u53d7\u4f53\u5728\u5927\u591a\u6570\u80f0\u817a\u764c\u7ec6\u80de\u4e0a\u90fd\u6709\u5f88\u9ad8\u7684\u5bc6\u5ea6\uff0c\u4f7f\u5176\u6210\u4e3a\u6709\u5438\u5f15\u529b\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u76ee\u6807\u3002<\/p>\n<p>\u03b1v\u03b26-integrin\u7684\u8868\u8fbe\u4e0e\u51e0\u79cd\u764c\u75c7\u7684\u751f\u5b58\u7387\u4e0b\u964d\u6709\u5173\u3002<\/p>\n<h2>\u7b2c\u4e00\u9636\u6bb5\u4e34\u5e8a\u8bd5\u9a8c<\/h2>\n<p>\u9996\u5e2d\u6267\u884c\u5b98Riccardo Canevari\u8bf4\uff0c\u6307\u5b9a &#8220;\u5b64\u513f &#8220;\u836f\u7269\u540e\uff0c\u5c06\u8fdb\u884c\u4ee5\u80f0\u817a\u764c\u4e3a\u91cd\u70b9\u76841\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<p>\u4ed6\u8bf4\uff1a&#8221;FDA\u7684\u51b3\u5b9a\u51f8\u663e\u4e86\u5bf9\u6709\u6548\u6210\u50cf\u5242\u7684\u5de8\u5927\u9700\u6c42\uff0c\u4ee5\u6539\u5584\u548c\u65e9\u671f\u8bca\u65ad\u80f0\u817a\u764c\uff0c\u5728\u6240\u6709\u764c\u75c7\u7c7b\u578b\u4e2d\uff0c\u80f0\u817a\u764c\u7684\u672a\u6ee1\u8db3\u9700\u6c42\u6c34\u5e73\u6700\u9ad8\uff0c&#8221;\u3002<\/p>\n<h2>\u6cbb\u7597\u7f55\u89c1\u75be\u75c5<\/h2>\n<p>\u88ab\u6307\u5b9a\u4e3a &#8220;\u5b64\u513f 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GmbH\u7b7e\u8ba2\u4e86\u72ec\u5bb6\u8bb8\u53ef\u534f\u8bae\uff0c\u5728\u7f8e\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u3001\u4e2d\u56fd\u3001\u9999\u6e2f\u548c\u65e5\u672c\u5f00\u53d1\u548c\u5546\u4e1a\u5316RAD 301\u3002<\/p>\n<h2>\u653e\u5c04\u6cbb\u7597<\/h2>\n<p>\u653e\u5c04\u6027\u836f\u7269\u4e3a\u6cbb\u7597\u6216\u8bca\u65ad\u76ee\u7684\u5411\u76ee\u6807\u7ec6\u80de\u63d0\u4f9b\u5c0f\u5242\u91cf\u7684\u8f90\u5c04\u3002<\/p>\n<p>Canevari\u5148\u751f\u8bf4\uff0c\u5b83\u4eec\u6b63\u8fc5\u901f\u6210\u4e3a\u80bf\u7624\u5b66\u4e2d\u6781\u5177\u524d\u666f\u7684\u6cbb\u7597\u524d\u6cbf\u3002<\/p>\n<p>&#8220;\u4ed6\u8bf4\uff1a&#8221;\u653e\u5c04\u6027\u836f\u7269\u4e3a\u90a3\u4e9b\u53ef\u80fd\u5df2\u7ecf\u7528\u5c3d\u6240\u6709\u5176\u4ed6\u6cbb\u7597\u65b9\u6cd5\u7684\u60a3\u8005\u63d0\u4f9b\u4e86\u65b0\u7684\u5e0c\u671b\u3002<\/p>\n<h2>GenesisCare\u5408\u4f5c<\/h2>\n<p>\u4eca\u5e743\u6708\uff0cRadiopharm\u516c\u53f8<a href=\"http:\/\/smallcaps-production.test\/radiopharm-theranostics-genesiscare-develop-solutions-hard-to-treat-cancers\/?lang=cn\">\u5ba3\u5e03\u4e0e\u6fb3\u5927\u5229\u4e9a\u516c\u53f8GenesisCare\u5efa\u7acb\u4e3a\u671f\u4e24\u5e74\u7684\u5408\u4f5c\u5173\u7cfb<\/a>\uff0c\u4e3a\u590d\u6742\u3001\u96be\u4ee5\u6cbb\u7597\u7684\u764c\u75c7\u5f00\u53d1\u65b0\u578b\u653e\u5c04\u6027\u836f\u7269\u3002<\/p>\n<p>\u4e24\u5bb6\u516c\u53f8\u5c06\u5728\u6fb3\u5927\u5229\u4e9a\u5408\u4f5c\u5f00\u5c55\u7b2c\u4e00\u9636\u6bb5\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u91cd\u70b9\u662f\u5728\u80bf\u7624\u5b66\u9700\u6c42\u672a\u5f97\u5230\u6ee1\u8db3\u7684\u5730\u533a\u8fdb\u884c\u836f\u7269\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u8bd5\u9a8c\u3002<\/p>\n<p>\u8fd9\u4e9b\u8bd5\u9a8c\u5c06\u6d89\u53ca\u6765\u81eaNano-mAbs\u5e73\u53f0\u7684\u4e13\u6709\u7eb3\u7c73\u6297\u4f53\uff0c\u8be5\u6297\u4f53\u9488\u5bf9\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2dPDL1\u7684\u8868\u8fbe\uff1b\u9488\u5bf9\u8111\u7624\u7684PTPu\u9776\u5411\u80bd\uff1b\u4ee5\u53ca\u9488\u5bf9\u524d\u5217\u817a\u764c\u7ec6\u80de\u4e2d\u6e38\u79bb\u7684\u4eba\u7c7b\u524d\u5217\u817a\u5361\u5229\u7d20\uff08PSA\uff09\u7684PSA\u9776\u5411\u6297\u4f53\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Radiopharm Theranostics (ASX: RAD) \u7684Ga68-Trivehexin\uff08RAD 301\uff09\u653e\u5c04\u6027\u836f\u7269\u6280\u672f\u5df2\u88ab\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\u6388\u4e88\u5b64\u513f\u836f\u7684\u79f0\u53f7\uff0c\u7528\u4e8e\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\uff08PDAC\uff09\u60a3\u8005\u7684\u6210\u50cf\u3002 Trivehexin\u662f\u4e00\u79cd\u4e13\u6709\u7684\u80bd\u57fa\u5206\u5b50\uff0c\u9488\u5bf9\u03b1v\u03b26-\u6574\u5408\u7d20\u7684\u7ec6\u80de\u6807\u8bb0\u7269\uff0c\u7528\u4e8e\u80bf\u7624\u4fb5\u88ad\u548c\u8f6c\u79fb\u6027\u751f\u957f\u3002 \u8be5\u53d7\u4f53\u5728\u5927\u591a\u6570\u80f0\u817a\u764c\u7ec6\u80de\u4e0a\u90fd\u6709\u5f88\u9ad8\u7684\u5bc6\u5ea6\uff0c\u4f7f\u5176\u6210\u4e3a\u6709\u5438\u5f15\u529b\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u76ee\u6807\u3002 \u03b1v\u03b26-integrin\u7684\u8868\u8fbe\u4e0e\u51e0\u79cd\u764c\u75c7\u7684\u751f\u5b58\u7387\u4e0b\u964d\u6709\u5173\u3002 \u7b2c\u4e00\u9636\u6bb5\u4e34\u5e8a\u8bd5\u9a8c \u9996\u5e2d\u6267\u884c\u5b98Riccardo Canevari\u8bf4\uff0c\u6307\u5b9a &#8220;\u5b64\u513f &#8220;\u836f\u7269\u540e\uff0c\u5c06\u8fdb\u884c\u4ee5\u80f0\u817a\u764c\u4e3a\u91cd\u70b9\u76841\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002 \u4ed6\u8bf4\uff1a&#8221;FDA\u7684\u51b3\u5b9a\u51f8\u663e\u4e86\u5bf9\u6709\u6548\u6210\u50cf\u5242\u7684\u5de8\u5927\u9700\u6c42\uff0c\u4ee5\u6539\u5584\u548c\u65e9\u671f\u8bca\u65ad\u80f0\u817a\u764c\uff0c\u5728\u6240\u6709\u764c\u75c7\u7c7b\u578b\u4e2d\uff0c\u80f0\u817a\u764c\u7684\u672a\u6ee1\u8db3\u9700\u6c42\u6c34\u5e73\u6700\u9ad8\uff0c&#8221;\u3002 \u6cbb\u7597\u7f55\u89c1\u75be\u75c5 \u88ab\u6307\u5b9a\u4e3a &#8220;\u5b64\u513f &#8220;\u7684\u836f\u7269\u6216\u751f\u7269\u5236\u54c1\u5177\u6709\u8bca\u65ad\u3001\u9884\u9632\u6216\u6cbb\u7597\u7f55\u89c1\u75be\u75c5\u548c\u75c5\u75c7\u7684\u6f5c\u529b\u3002 \u63a5\u53d7\u8005\u53ef\u4ee5\u83b7\u5f97\u5305\u62ec\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7a0e\u6536\u51cf\u514d\u5728\u5185\u7684\u597d\u5904\uff0c\u5982\u679c\u4ed6\u4eec\u7684\u836f\u7269\u83b7\u5f97\u6279\u51c6\uff0c\u8fd8\u53ef\u4ee5\u83b7\u5f97\u4e03\u5e74\u7684\u5e02\u573a\u72ec\u5bb6\u7ecf\u8425\u6743\u3002 Radiopharm\u62e5\u6709\u4e24\u4e2a\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u6307\u5b9a\u7684\u5b64\u513f\u836f\uff0c\u540c\u65f6\u8fd8\u6709\u7528\u4e8e\u6cbb\u7597\u9aa8\u8089\u7624\u60a3\u8005\u7684LRRC15\u6297\u4f53DUNP19\u3002 \u8be5\u516c\u53f8\u5df2\u4e0e\u5fb7\u56fd\u653e\u5c04\u6027\u836f\u7269\u516c\u53f8TRIMT GmbH\u7b7e\u8ba2\u4e86\u72ec\u5bb6\u8bb8\u53ef\u534f\u8bae\uff0c\u5728\u7f8e\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u3001\u4e2d\u56fd\u3001\u9999\u6e2f\u548c\u65e5\u672c\u5f00\u53d1\u548c\u5546\u4e1a\u5316RAD 301\u3002 \u653e\u5c04\u6cbb\u7597 \u653e\u5c04\u6027\u836f\u7269\u4e3a\u6cbb\u7597\u6216\u8bca\u65ad\u76ee\u7684\u5411\u76ee\u6807\u7ec6\u80de\u63d0\u4f9b\u5c0f\u5242\u91cf\u7684\u8f90\u5c04\u3002 Canevari\u5148\u751f\u8bf4\uff0c\u5b83\u4eec\u6b63\u8fc5\u901f\u6210\u4e3a\u80bf\u7624\u5b66\u4e2d\u6781\u5177\u524d\u666f\u7684\u6cbb\u7597\u524d\u6cbf\u3002 &#8220;\u4ed6\u8bf4\uff1a&#8221;\u653e\u5c04\u6027\u836f\u7269\u4e3a\u90a3\u4e9b\u53ef\u80fd\u5df2\u7ecf\u7528\u5c3d\u6240\u6709\u5176\u4ed6\u6cbb\u7597\u65b9\u6cd5\u7684\u60a3\u8005\u63d0\u4f9b\u4e86\u65b0\u7684\u5e0c\u671b\u3002 GenesisCare\u5408\u4f5c \u4eca\u5e743\u6708\uff0cRadiopharm\u516c\u53f8\u5ba3\u5e03\u4e0e\u6fb3\u5927\u5229\u4e9a\u516c\u53f8GenesisCare\u5efa\u7acb\u4e3a\u671f\u4e24\u5e74\u7684\u5408\u4f5c\u5173\u7cfb\uff0c\u4e3a\u590d\u6742\u3001\u96be\u4ee5\u6cbb\u7597\u7684\u764c\u75c7\u5f00\u53d1\u65b0\u578b\u653e\u5c04\u6027\u836f\u7269\u3002 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