{"id":7098,"date":"2023-07-07T01:07:47","date_gmt":"2023-07-07T01:07:47","guid":{"rendered":"\/\/smallcapscn.x5view.co\/?p=7098"},"modified":"2023-08-29T18:01:19","modified_gmt":"2023-08-29T18:01:19","slug":"imugene-ready-next-phase-breast-cancer-treatment-trial","status":"publish","type":"post","link":"https:\/\/smallcapscn.x5view.co\/?p=7098","title":{"rendered":"Imugene\u56e0\u4e3a\u4e73\u817a\u764c\u6cbb\u7597\u8bd5\u9a8c\u7684\u4e0b\u4e00\u9636\u6bb5\u505a\u597d\u51c6\u5907"},"content":{"rendered":"

\u4e34\u5e8a\u9636\u6bb5\u514d\u75ab\u80bf\u7624\u5b66\u516c\u53f8Imugene (ASX: IMU)\u8bc1\u5b9e\uff0c\u4e16\u754c\u8457\u540d\u7684\u5e0c\u671b\u4e4b\u57ce\u72ec\u7acb\u764c\u75c7\u7814\u7a76\u548c\u6cbb\u7597\u4e2d\u5fc3\u5c06\u5728\u7f8e\u56fd\u9886\u5bfc\u4e00\u9879\u65b0\u7684\u4e73\u817a\u764c\u6cbb\u7597\u8bd5\u9a8c\u3002<\/p>\n

\u4f4d\u4e8e\u6d1b\u6749\u77f6\u9644\u8fd1\u7684City of Hope\u76ee\u524d\u6b63\u51c6\u5907\u5f00\u5c55Imugene\u7684\u6eb6\u7624\u75c5\u6bd2\u6cbb\u7597\u5019\u9009\u836f\u7269CHECKvacc (HOV3, CF33-hNIS-anti-PDL1)\u7684\u7b2c\u56db\u5242\u91cf\u961f\u5217I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n

\u4e00\u79cd\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6b66\u88c5\u5d4c\u5408\u75d8\u75d8\u75c5\u6bd2\uff0cCF33-hNIS-antiPDL1\uff0c\u5728CF33\u53d1\u660e\u4eba\u548c\u5907\u53d7\u5c0a\u656c\u7684\u4e13\u5bb6\u65b9\u80b2\u66fc\u6559\u6388\u7684\u5b9e\u9a8c\u5ba4\u5f00\u53d1\u3002<\/p>\n

\u7279\u522b\u8bbe\u8ba1\u7684\u80bf\u7624\u7ec6\u80de\u6740\u624b<\/h2>\n

\u6eb6\u7624\u75c5\u6bd2(OVs)\u88ab\u8bbe\u8ba1\u7528\u4e8e\u9009\u62e9\u6027\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u548c\u6fc0\u6d3b\u9488\u5bf9\u764c\u7ec6\u80de\u7684\u514d\u75ab\u7cfb\u7edf\uff0c\u5177\u6709\u6539\u5584\u4e34\u5e8a\u53cd\u5e94\u548c\u751f\u5b58\u7387\u7684\u6f5c\u529b\u3002<\/p>\n

\u636e\u4f30\u8ba1\uff0c2023\u5e74\u4ec5\u5728\u7f8e\u56fd\u5c31\u5c06\u670943,700\u4eba\u6b7b\u4e8e\u4e73\u817a\u764c(43,170\u540d\u5973\u6027\u548c530\u540d\u7537\u6027)\u3002<\/p>\n

\u7136\u800c\uff0c\u65b0\u7684\u7814\u7a76\u5728\u6cbb\u7597\u4e09\u9634\u6027\u4e73\u817a\u764c(TNBC)\u65b9\u9762\u53d6\u5f97\u4e86\u7a81\u7834\uff0c\u4e09\u9634\u6027\u4e73\u817a\u764c\u662f\u4e00\u79cd\u4fb5\u88ad\u6027\u4e73\u817a\u764c\u4e9a\u578b(\u7ea6\u5360\u6240\u6709\u4e73\u817a\u764c\u60a3\u8005\u768420%)\uff0c\u4e2d\u4f4d\u751f\u5b58\u671f\u4e3a12\u4e2a\u6708\u3002<\/p>\n

\u6839\u636eImugene\u7684\u7814\u7a76\uff0c\u9664\u4e86\u79cd\u7cfbBRCA\u7a81\u53d8\u7684\u80bf\u7624\u5916\uff0c\u76ee\u524d\u8fd8\u6ca1\u6709\u9488\u5bf9\u8f6c\u79fb\u6027TNBC\u60a3\u8005\u7684\u6709\u6548\u9776\u5411\u6cbb\u7597\uff0c\u8fd9\u8868\u660eTNBC\u662f\u4e00\u4e2a\u672a\u6ee1\u8db3\u9700\u6c42\u7684\u9886\u57df\u3002<\/p>\n

\u6d4b\u8bd5\u6cbb\u7597\u5b89\u5168\u6027\u7684\u65b0\u7814\u7a76<\/h2>\n

Imugene\u8463\u4e8b\u603b\u7ecf\u7406Leslie Chong\u8bf4\uff0c\u8be5\u516c\u53f8\u76ee\u524d\u7814\u7a76\u7684\u76ee\u7684\u662f\u8bc4\u4f30CF33-hNIS-antiPDL1\u5728\u80bf\u7624\u5185\u6cbb\u7597\u8f6c\u79fb\u6027TNBC\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u521d\u6b65\u8bc1\u636e\u3002<\/p>\n

\u4e0b\u4e00\u4e2a\u5242\u91cf\u961f\u5217\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u5728\u65b9\u6848\u7ba1\u7406\u56e2\u961f\u6279\u51c6\u540e\uff0c\u8be5\u56e2\u961f\u53d1\u73b0CHECKvacc\u662f\u5b89\u5168\u7684\uff0c\u6ca1\u6709\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027(dlt)\uff0c\u5e76\u4e14\u5728\u5ba1\u67e5\u4e86\u524d3\u4e2a\u961f\u5217\u4f7f\u7528CHECKvacc\u4f5c\u4e3a\u5355\u836f\u6cbb\u7597\u7684\u6240\u6709\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u6570\u636e\u540e\uff0c\u6ca1\u6709\u89c2\u5bdf\u5230\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\u3002<\/p>\n

Chong\u5973\u58eb\u8bf4\uff0cCHECKvacc\u7684\u9996\u6b21\u4eba\u4f531\u671f\u5355\u4e2d\u5fc3\u5242\u91cf\u9012\u589e\u7814\u7a76\u6b63\u5728\u62db\u52df\u4e09\u9634\u6027\u4e73\u817a\u764c(TNBC)\u60a3\u8005\u3002<\/p>\n

\u9010\u6b65\u5347\u7ea7\u8bd5\u9a8c\u8bbe\u8ba1<\/h2>\n

\u6839\u636e\u76ee\u524d\u7684\u8bd5\u9a8c\u8bbe\u8ba1\uff0c\u521d\u59cb\u5242\u91cf\u5c06\u589e\u52a0\uff0c\u6700\u540e\u5242\u91cf\u5c06\u6269\u5927\u523012\u540d\u60a3\u8005\uff0c\u8fd9\u5c06\u662f\u63a8\u8350\u76842\u671f\u5242\u91cf(RP2D)\u3002<\/p>\n

\u201c\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u6211\u4eec\u5bf9\u6211\u4eec\u6240\u770b\u5230\u7684\u7ed3\u679c\u611f\u5230\u6ee1\u610f\uff0c\u6ca1\u6709\u89c2\u5bdf\u5230\u6bd2\u6027\uff0c\u5728TNBC\u80bf\u7624\u4e2d\u6eb6\u7624\u75c5\u6bd2\u611f\u67d3\u548c\u590d\u5236\u7684\u65e9\u671f\u7ed3\u679c\u4ee4\u4eba\u9f13\u821e\u3002\u6211\u4eec\u671f\u5f85\u7ee7\u7eed\u8fdb\u884c\u8fd9\u9879\u7814\u7a76\uff0c\u5e76\u5411\u5e02\u573a\u62a5\u544a\u7814\u7a76\u8fdb\u5c55\u3002\u201d<\/p>\n

\u5ba1\u5224\u9884\u8ba1\u5c06\u6301\u7eed24\u4e2a\u6708\u3002<\/p>\n

\u5f3a\u5411\u524d\u8ba1\u5212<\/h2>\n

\u672c\u5468\u65e9\u4e9b\u65f6\u5019\uff0c\u516c\u53f8\u6267\u884c\u8463\u4e8b\u957fPaul Hopper\u5728\u81f4\u80a1\u4e1c\u7684\u4e00\u5c01\u4fe1\u4e2d\u6307\u51fa\uff0c\u5c3d\u7ba1\u5168\u7403\u548c\u6fb3\u5927\u5229\u4e9a\u5e02\u573a\u7684\u751f\u7269\u6280\u672f\u884c\u4e1a\u53d1\u5c55\u7f13\u6162\uff0c\u4f46Imugene\u56e2\u961f\u5df2\u7ecf\u5728\u516c\u53f8\u7684\u8bb8\u591a\u9879\u76ee\u4e0a\u53d6\u5f97\u4e86\u8fdb\u5c55\uff0c\u7ba1\u7406\u4e86\u7a33\u56fa\u7684\u73b0\u91d1\u72b6\u51b5\uff0c\u5e76\u5728\u5e02\u573a\u56de\u5f52\u4ef7\u503c\u6295\u8d44\u65f6\u5bf9\u81ea\u8eab\u8fdb\u884c\u4e86\u6218\u7565\u6027\u5b9a\u4f4d\uff0c\u4ee5\u91cd\u65b0\u8bc4\u4f30\u5176\u4ef7\u503c\u3002<\/p>\n

\u8be5\u516c\u53f8\u76ee\u524d\u7684\u4eae\u70b9\u5305\u62ec\u62e5\u6709\u8d85\u8fc71.5\u4ebf\u6fb3\u5143\u73b0\u91d1\u7684\u7a33\u5065\u8d44\u4ea7\u8d1f\u503a\u8868\uff0c\u8db3\u4ee5\u652f\u6301\u4e24\u5e74\u591a\u7684\u9879\u76ee\u5f00\u53d1\u6295\u8d44\u3002<\/p>\n

Imugene\u7684CD19\u75c5\u6bd2\u83b7\u5f97\u4e86FDA\u7684IND\u8bb8\u53ef\uff0c\u4e3a\u4eca\u5e74\u5f00\u59cb\u7684\u4e34\u5e8a\u8bd5\u9a8c\u94fa\u5e73\u4e86\u9053\u8def\uff0c\u8be5\u516c\u53f8\u8ba4\u4e3a\u8be5\u9879\u76ee\u53ef\u80fd\u4f1a\u6539\u53d8\u5b9e\u4f53\u80bf\u7624\u7684\u6e38\u620f\u89c4\u5219\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u4e34\u5e8a\u9636\u6bb5\u514d\u75ab\u80bf\u7624\u5b66\u516c\u53f8Imugene (ASX: IMU)\u8bc1\u5b9e\uff0c\u4e16\u754c\u8457\u540d\u7684\u5e0c\u671b\u4e4b\u57ce\u72ec\u7acb\u764c\u75c7\u7814\u7a76\u548c\u6cbb\u7597\u4e2d\u5fc3\u5c06\u5728\u7f8e\u56fd\u9886\u5bfc\u4e00\u9879\u65b0\u7684\u4e73\u817a\u764c\u6cbb\u7597\u8bd5\u9a8c\u3002 \u4f4d\u4e8e\u6d1b\u6749\u77f6\u9644\u8fd1\u7684City of Hope\u76ee\u524d\u6b63\u51c6\u5907\u5f00\u5c55Imugene\u7684\u6eb6\u7624\u75c5\u6bd2\u6cbb\u7597\u5019\u9009\u836f\u7269CHECKvacc (HOV3, CF33-hNIS-anti-PDL1)\u7684\u7b2c\u56db\u5242\u91cf\u961f\u5217I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002 \u4e00\u79cd\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6b66\u88c5\u5d4c\u5408\u75d8\u75d8\u75c5\u6bd2\uff0cCF33-hNIS-antiPDL1\uff0c\u5728CF33\u53d1\u660e\u4eba\u548c\u5907\u53d7\u5c0a\u656c\u7684\u4e13\u5bb6\u65b9\u80b2\u66fc\u6559\u6388\u7684\u5b9e\u9a8c\u5ba4\u5f00\u53d1\u3002 \u7279\u522b\u8bbe\u8ba1\u7684\u80bf\u7624\u7ec6\u80de\u6740\u624b \u6eb6\u7624\u75c5\u6bd2(OVs)\u88ab\u8bbe\u8ba1\u7528\u4e8e\u9009\u62e9\u6027\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u548c\u6fc0\u6d3b\u9488\u5bf9\u764c\u7ec6\u80de\u7684\u514d\u75ab\u7cfb\u7edf\uff0c\u5177\u6709\u6539\u5584\u4e34\u5e8a\u53cd\u5e94\u548c\u751f\u5b58\u7387\u7684\u6f5c\u529b\u3002 \u636e\u4f30\u8ba1\uff0c2023\u5e74\u4ec5\u5728\u7f8e\u56fd\u5c31\u5c06\u670943,700\u4eba\u6b7b\u4e8e\u4e73\u817a\u764c(43,170\u540d\u5973\u6027\u548c530\u540d\u7537\u6027)\u3002 \u7136\u800c\uff0c\u65b0\u7684\u7814\u7a76\u5728\u6cbb\u7597\u4e09\u9634\u6027\u4e73\u817a\u764c(TNBC)\u65b9\u9762\u53d6\u5f97\u4e86\u7a81\u7834\uff0c\u4e09\u9634\u6027\u4e73\u817a\u764c\u662f\u4e00\u79cd\u4fb5\u88ad\u6027\u4e73\u817a\u764c\u4e9a\u578b(\u7ea6\u5360\u6240\u6709\u4e73\u817a\u764c\u60a3\u8005\u768420%)\uff0c\u4e2d\u4f4d\u751f\u5b58\u671f\u4e3a12\u4e2a\u6708\u3002 \u6839\u636eImugene\u7684\u7814\u7a76\uff0c\u9664\u4e86\u79cd\u7cfbBRCA\u7a81\u53d8\u7684\u80bf\u7624\u5916\uff0c\u76ee\u524d\u8fd8\u6ca1\u6709\u9488\u5bf9\u8f6c\u79fb\u6027TNBC\u60a3\u8005\u7684\u6709\u6548\u9776\u5411\u6cbb\u7597\uff0c\u8fd9\u8868\u660eTNBC\u662f\u4e00\u4e2a\u672a\u6ee1\u8db3\u9700\u6c42\u7684\u9886\u57df\u3002 \u6d4b\u8bd5\u6cbb\u7597\u5b89\u5168\u6027\u7684\u65b0\u7814\u7a76 Imugene\u8463\u4e8b\u603b\u7ecf\u7406Leslie Chong\u8bf4\uff0c\u8be5\u516c\u53f8\u76ee\u524d\u7814\u7a76\u7684\u76ee\u7684\u662f\u8bc4\u4f30CF33-hNIS-antiPDL1\u5728\u80bf\u7624\u5185\u6cbb\u7597\u8f6c\u79fb\u6027TNBC\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u521d\u6b65\u8bc1\u636e\u3002 \u4e0b\u4e00\u4e2a\u5242\u91cf\u961f\u5217\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u5728\u65b9\u6848\u7ba1\u7406\u56e2\u961f\u6279\u51c6\u540e\uff0c\u8be5\u56e2\u961f\u53d1\u73b0CHECKvacc\u662f\u5b89\u5168\u7684\uff0c\u6ca1\u6709\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027(dlt)\uff0c\u5e76\u4e14\u5728\u5ba1\u67e5\u4e86\u524d3\u4e2a\u961f\u5217\u4f7f\u7528CHECKvacc\u4f5c\u4e3a\u5355\u836f\u6cbb\u7597\u7684\u6240\u6709\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u6570\u636e\u540e\uff0c\u6ca1\u6709\u89c2\u5bdf\u5230\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\u3002 Chong\u5973\u58eb\u8bf4\uff0cCHECKvacc\u7684\u9996\u6b21\u4eba\u4f531\u671f\u5355\u4e2d\u5fc3\u5242\u91cf\u9012\u589e\u7814\u7a76\u6b63\u5728\u62db\u52df\u4e09\u9634\u6027\u4e73\u817a\u764c(TNBC)\u60a3\u8005\u3002 \u9010\u6b65\u5347\u7ea7\u8bd5\u9a8c\u8bbe\u8ba1 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